Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms
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Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms. / Nana, Petroula; Jama, Katarzyna; Kölbel, Tilo; Spanos, Konstantinos; Panuccio, Giuseppe; Jakimowicz, Tomasz; Rohlffs, Fiona.
In: J CLIN MED, Vol. 12, No. 18, 5811, 07.09.2023.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms
AU - Nana, Petroula
AU - Jama, Katarzyna
AU - Kölbel, Tilo
AU - Spanos, Konstantinos
AU - Panuccio, Giuseppe
AU - Jakimowicz, Tomasz
AU - Rohlffs, Fiona
PY - 2023/9/7
Y1 - 2023/9/7
N2 - INTRODUCTION: Females are at increased risk of mortality compared to males after complex endovascular aortic repair. This study aims to examine sex-related peri-operative and follow-up outcomes in patients managed with the t-Branch device.METHODS: A two-center retrospective analysis of patients managed with the off-the-shelf t-Branch device (Cook Medical Inc., Bjaeverskov, Denmark) between 1 January 2014 and 30 September 2020 was performed. Primary outcomes were sex-comparative 30-day mortality, major adverse events (MAEs) and spinal cord ischemia (SCI).RESULTS: A total of 542 patients were included; 28.0% were females. Urgent repair and type I-III thoracoabdominal aneurysms were more common among females (52.6% vs. 34%, p = 0.01, and 57.1% vs. 35.8%, p = 0.004). Technical success was similar (97.4% vs. 96.9%, p = 0.755), as well as early mortality (16.2% in females vs. 10.8% in males; p = 0.084). SCI rates were similar between groups (13.6% vs. 9.2% p = 0.183). MAEs were more common in females; 33.7% vs. 21.4% (p = 0.022). Multivariate analysis did not identify sex as an independent predictor of adverse events. The 12-month survival rate was 75.7% (SE 0.045) for females and 84.1% (SE 0.026) for males (log rank, p = 0.10).CONCLUSIONS: Sex was not detected as an independent factor of mortality, MAEs and SCI within patients managed with the t-Branch device. Feasibility was high in both groups. No significant difference was shown in survival during the 12-month follow-up.
AB - INTRODUCTION: Females are at increased risk of mortality compared to males after complex endovascular aortic repair. This study aims to examine sex-related peri-operative and follow-up outcomes in patients managed with the t-Branch device.METHODS: A two-center retrospective analysis of patients managed with the off-the-shelf t-Branch device (Cook Medical Inc., Bjaeverskov, Denmark) between 1 January 2014 and 30 September 2020 was performed. Primary outcomes were sex-comparative 30-day mortality, major adverse events (MAEs) and spinal cord ischemia (SCI).RESULTS: A total of 542 patients were included; 28.0% were females. Urgent repair and type I-III thoracoabdominal aneurysms were more common among females (52.6% vs. 34%, p = 0.01, and 57.1% vs. 35.8%, p = 0.004). Technical success was similar (97.4% vs. 96.9%, p = 0.755), as well as early mortality (16.2% in females vs. 10.8% in males; p = 0.084). SCI rates were similar between groups (13.6% vs. 9.2% p = 0.183). MAEs were more common in females; 33.7% vs. 21.4% (p = 0.022). Multivariate analysis did not identify sex as an independent predictor of adverse events. The 12-month survival rate was 75.7% (SE 0.045) for females and 84.1% (SE 0.026) for males (log rank, p = 0.10).CONCLUSIONS: Sex was not detected as an independent factor of mortality, MAEs and SCI within patients managed with the t-Branch device. Feasibility was high in both groups. No significant difference was shown in survival during the 12-month follow-up.
U2 - 10.3390/jcm12185811
DO - 10.3390/jcm12185811
M3 - SCORING: Journal article
C2 - 37762752
VL - 12
JO - J CLIN MED
JF - J CLIN MED
SN - 2077-0383
IS - 18
M1 - 5811
ER -