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Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence

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Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence. / Frere, Pauline Bezivin; Vetter, Nora C; Artiges, Eric; Filippi, Irina; Miranda, Rubén; Vulser, Hélène; Paillère-Martinot, Marie-Laure; Ziesch, Veronika; Conrod, Patricia; Cattrell, Anna; Walter, Henrik; Gallinat, Jurgen; Bromberg, Uli; Rodehacke, Sarah; Menningen, Eva; Frouin, Vincent; Papadopoulos-Orfanos, Dimitri; Stringaris, Argyris; Penttilä, Jani; van Noort, Betteke; Grimmer, Yvonne; Schumann, Gunter; Smolka, Michael N; Martinot, Jean-Luc; Lemaître, Hervé; IMAGEN Consortium.

In: NEUROIMAGE, Vol. 210, 15.04.2020, p. 116441.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Frere, PB, Vetter, NC, Artiges, E, Filippi, I, Miranda, R, Vulser, H, Paillère-Martinot, M-L, Ziesch, V, Conrod, P, Cattrell, A, Walter, H, Gallinat, J, Bromberg, U, Rodehacke, S, Menningen, E, Frouin, V, Papadopoulos-Orfanos, D, Stringaris, A, Penttilä, J, van Noort, B, Grimmer, Y, Schumann, G, Smolka, MN, Martinot, J-L, Lemaître, H & IMAGEN Consortium 2020, 'Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence', NEUROIMAGE, vol. 210, pp. 116441. https://doi.org/10.1016/j.neuroimage.2019.116441

APA

Frere, P. B., Vetter, N. C., Artiges, E., Filippi, I., Miranda, R., Vulser, H., Paillère-Martinot, M-L., Ziesch, V., Conrod, P., Cattrell, A., Walter, H., Gallinat, J., Bromberg, U., Rodehacke, S., Menningen, E., Frouin, V., Papadopoulos-Orfanos, D., Stringaris, A., Penttilä, J., ... IMAGEN Consortium (2020). Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence. NEUROIMAGE, 210, 116441. https://doi.org/10.1016/j.neuroimage.2019.116441

Vancouver

Frere PB, Vetter NC, Artiges E, Filippi I, Miranda R, Vulser H et al. Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence. NEUROIMAGE. 2020 Apr 15;210:116441. https://doi.org/10.1016/j.neuroimage.2019.116441

Bibtex

@article{cedee5cc0afd4a52b2855e3794f9d1f6,
title = "Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence",
abstract = "Though adolescence is a time of emerging sex differences in emotions, sex-related differences in the anatomy of the maturing brain has been under-explored over this period. The aim of this study was to investigate whether puberty and sexual differentiation in brain maturation could explain emotional differences between girls and boys during adolescence. We adapted a dedicated longitudinal pipeline to process structural and diffusion images from 335 typically developing adolescents between 14 and 16 years. We used voxel-based and Regions of Interest approaches to explore sex and puberty effects on brain and behavioral changes during adolescence. Sexual differences in brain maturation were characterized by amygdala and hippocampal volume increase in boys and decrease in girls. These changes were mediating the sexual differences in positive emotional regulation as illustrated by positive attributes increase in boys and decrease in girls. Moreover, the differential maturation rates between the limbic system and the prefrontal cortex highlighted the delayed maturation in boys compared to girls. This is the first study to show the sex effects on the differential cortico/subcortical maturation rates and the interaction between sex and puberty in the limbic system maturation related to positive attributes, reported as being protective from emotional disorders.",
author = "Frere, {Pauline Bezivin} and Vetter, {Nora C} and Eric Artiges and Irina Filippi and Rub{\'e}n Miranda and H{\'e}l{\`e}ne Vulser and Marie-Laure Paill{\`e}re-Martinot and Veronika Ziesch and Patricia Conrod and Anna Cattrell and Henrik Walter and Jurgen Gallinat and Uli Bromberg and Sarah Rodehacke and Eva Menningen and Vincent Frouin and Dimitri Papadopoulos-Orfanos and Argyris Stringaris and Jani Penttil{\"a} and {van Noort}, Betteke and Yvonne Grimmer and Gunter Schumann and Smolka, {Michael N} and Jean-Luc Martinot and Herv{\'e} Lema{\^i}tre and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = apr,
day = "15",
doi = "10.1016/j.neuroimage.2019.116441",
language = "English",
volume = "210",
pages = "116441",
journal = "NEUROIMAGE",
issn = "1053-8119",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence

AU - Frere, Pauline Bezivin

AU - Vetter, Nora C

AU - Artiges, Eric

AU - Filippi, Irina

AU - Miranda, Rubén

AU - Vulser, Hélène

AU - Paillère-Martinot, Marie-Laure

AU - Ziesch, Veronika

AU - Conrod, Patricia

AU - Cattrell, Anna

AU - Walter, Henrik

AU - Gallinat, Jurgen

AU - Bromberg, Uli

AU - Rodehacke, Sarah

AU - Menningen, Eva

AU - Frouin, Vincent

AU - Papadopoulos-Orfanos, Dimitri

AU - Stringaris, Argyris

AU - Penttilä, Jani

AU - van Noort, Betteke

AU - Grimmer, Yvonne

AU - Schumann, Gunter

AU - Smolka, Michael N

AU - Martinot, Jean-Luc

AU - Lemaître, Hervé

AU - IMAGEN Consortium

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2020/4/15

Y1 - 2020/4/15

N2 - Though adolescence is a time of emerging sex differences in emotions, sex-related differences in the anatomy of the maturing brain has been under-explored over this period. The aim of this study was to investigate whether puberty and sexual differentiation in brain maturation could explain emotional differences between girls and boys during adolescence. We adapted a dedicated longitudinal pipeline to process structural and diffusion images from 335 typically developing adolescents between 14 and 16 years. We used voxel-based and Regions of Interest approaches to explore sex and puberty effects on brain and behavioral changes during adolescence. Sexual differences in brain maturation were characterized by amygdala and hippocampal volume increase in boys and decrease in girls. These changes were mediating the sexual differences in positive emotional regulation as illustrated by positive attributes increase in boys and decrease in girls. Moreover, the differential maturation rates between the limbic system and the prefrontal cortex highlighted the delayed maturation in boys compared to girls. This is the first study to show the sex effects on the differential cortico/subcortical maturation rates and the interaction between sex and puberty in the limbic system maturation related to positive attributes, reported as being protective from emotional disorders.

AB - Though adolescence is a time of emerging sex differences in emotions, sex-related differences in the anatomy of the maturing brain has been under-explored over this period. The aim of this study was to investigate whether puberty and sexual differentiation in brain maturation could explain emotional differences between girls and boys during adolescence. We adapted a dedicated longitudinal pipeline to process structural and diffusion images from 335 typically developing adolescents between 14 and 16 years. We used voxel-based and Regions of Interest approaches to explore sex and puberty effects on brain and behavioral changes during adolescence. Sexual differences in brain maturation were characterized by amygdala and hippocampal volume increase in boys and decrease in girls. These changes were mediating the sexual differences in positive emotional regulation as illustrated by positive attributes increase in boys and decrease in girls. Moreover, the differential maturation rates between the limbic system and the prefrontal cortex highlighted the delayed maturation in boys compared to girls. This is the first study to show the sex effects on the differential cortico/subcortical maturation rates and the interaction between sex and puberty in the limbic system maturation related to positive attributes, reported as being protective from emotional disorders.

U2 - 10.1016/j.neuroimage.2019.116441

DO - 10.1016/j.neuroimage.2019.116441

M3 - SCORING: Journal article

C2 - 31811901

VL - 210

SP - 116441

JO - NEUROIMAGE

JF - NEUROIMAGE

SN - 1053-8119

ER -