Research ExplorerPublicationsSex Disparities in Long-Term Mortality after Paclitaxel Expo...

Sex Disparities in Long-Term Mortality after Paclitaxel Exposure in Patients with Peripheral Artery Disease: A Nationwide Claims-Based Cohort Study

Standard

Sex Disparities in Long-Term Mortality after Paclitaxel Exposure in Patients with Peripheral Artery Disease: A Nationwide Claims-Based Cohort Study. / Behrendt, Christian-Alexander; Sedrakyan, Art; Katsanos, Konstantinos; Nordanstig, Joakim; Kuchenbecker, Jenny; Kreutzburg, Thea; Secemsky, Eric A; Debus, Eike Sebastian; Marschall, Ursula; Peters, Frederik.

In: J CLIN MED, Vol. 10, No. 13, 2978, 02.07.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Behrendt, C-A, Sedrakyan, A, Katsanos, K, Nordanstig, J, Kuchenbecker, J, Kreutzburg, T, Secemsky, EA, Debus, ES, Marschall, U & Peters, F 2021, 'Sex Disparities in Long-Term Mortality after Paclitaxel Exposure in Patients with Peripheral Artery Disease: A Nationwide Claims-Based Cohort Study', J CLIN MED, vol. 10, no. 13, 2978. https://doi.org/10.3390/jcm10132978

APA

Behrendt, C-A., Sedrakyan, A., Katsanos, K., Nordanstig, J., Kuchenbecker, J., Kreutzburg, T., Secemsky, E. A., Debus, E. S., Marschall, U., & Peters, F. (2021). Sex Disparities in Long-Term Mortality after Paclitaxel Exposure in Patients with Peripheral Artery Disease: A Nationwide Claims-Based Cohort Study. J CLIN MED, 10(13), [2978]. https://doi.org/10.3390/jcm10132978

Vancouver

Behrendt C-A, Sedrakyan A, Katsanos K, Nordanstig J, Kuchenbecker J, Kreutzburg T et al. Sex Disparities in Long-Term Mortality after Paclitaxel Exposure in Patients with Peripheral Artery Disease: A Nationwide Claims-Based Cohort Study. J CLIN MED. 2021 Jul 2;10(13). 2978. https://doi.org/10.3390/jcm10132978

Bibtex

@article{8fcde3180fa9495eb676d2a49f4e62ae,
title = "Sex Disparities in Long-Term Mortality after Paclitaxel Exposure in Patients with Peripheral Artery Disease: A Nationwide Claims-Based Cohort Study",
abstract = "BACKGROUND: Randomized controlled trials have reported excess mortality in patients treated with paclitaxel-coated devices versus uncoated devices, while observational studies have reported the opposite. This study aims to determine the underlying factors and cohort differences that may explain these opposite results, with specific focus on sex differences in treatment and outcomes.METHODS: Multicenter health insurance claims data from a large insurance fund, BARMER, were studied. A homogeneous sample of patients with an index of endovascular revascularization for symptomatic peripheral arterial occlusive disease between 2013 and 2017 was included. Adjusted logistic regression and Cox regression models were used to determine the factors predicting allocation to paclitaxel-coated devices and sex-specific 5-year all-cause mortality, respectively.RESULTS: In total, 13,204 patients (54% females, mean age 74 ± 11 years) were followed for a median of 3.5 years. Females were older (77 vs. 71 years), and had less frequent coronary artery disease (23% vs. 33%), dyslipidemia (44% vs. 50%), and diabetes (29% vs. 41%), as well as being less likely to have a history of smoking (10% vs. 15%) compared with males. Mortality differences were mostly attributable to the female subgroup who were revascularized above the knee (hazard ratio, HR 0.78, 95% CI: 0.64-0.95), while no statistically significant differences were observed in males.CONCLUSIONS: This study found that females treated above the knee benefited from paclitaxel-coated devices, while no differences were found in males. Ongoing and future registries and trials should take sex disparities into account.",
author = "Christian-Alexander Behrendt and Art Sedrakyan and Konstantinos Katsanos and Joakim Nordanstig and Jenny Kuchenbecker and Thea Kreutzburg and Secemsky, {Eric A} and Debus, {Eike Sebastian} and Ursula Marschall and Frederik Peters",
year = "2021",
month = jul,
day = "2",
doi = "10.3390/jcm10132978",
language = "English",
volume = "10",
journal = "J CLIN MED",
issn = "2077-0383",
publisher = "MDPI AG",
number = "13",

}

RIS

TY - JOUR

T1 - Sex Disparities in Long-Term Mortality after Paclitaxel Exposure in Patients with Peripheral Artery Disease: A Nationwide Claims-Based Cohort Study

AU - Behrendt, Christian-Alexander

AU - Sedrakyan, Art

AU - Katsanos, Konstantinos

AU - Nordanstig, Joakim

AU - Kuchenbecker, Jenny

AU - Kreutzburg, Thea

AU - Secemsky, Eric A

AU - Debus, Eike Sebastian

AU - Marschall, Ursula

AU - Peters, Frederik

PY - 2021/7/2

Y1 - 2021/7/2

N2 - BACKGROUND: Randomized controlled trials have reported excess mortality in patients treated with paclitaxel-coated devices versus uncoated devices, while observational studies have reported the opposite. This study aims to determine the underlying factors and cohort differences that may explain these opposite results, with specific focus on sex differences in treatment and outcomes.METHODS: Multicenter health insurance claims data from a large insurance fund, BARMER, were studied. A homogeneous sample of patients with an index of endovascular revascularization for symptomatic peripheral arterial occlusive disease between 2013 and 2017 was included. Adjusted logistic regression and Cox regression models were used to determine the factors predicting allocation to paclitaxel-coated devices and sex-specific 5-year all-cause mortality, respectively.RESULTS: In total, 13,204 patients (54% females, mean age 74 ± 11 years) were followed for a median of 3.5 years. Females were older (77 vs. 71 years), and had less frequent coronary artery disease (23% vs. 33%), dyslipidemia (44% vs. 50%), and diabetes (29% vs. 41%), as well as being less likely to have a history of smoking (10% vs. 15%) compared with males. Mortality differences were mostly attributable to the female subgroup who were revascularized above the knee (hazard ratio, HR 0.78, 95% CI: 0.64-0.95), while no statistically significant differences were observed in males.CONCLUSIONS: This study found that females treated above the knee benefited from paclitaxel-coated devices, while no differences were found in males. Ongoing and future registries and trials should take sex disparities into account.

AB - BACKGROUND: Randomized controlled trials have reported excess mortality in patients treated with paclitaxel-coated devices versus uncoated devices, while observational studies have reported the opposite. This study aims to determine the underlying factors and cohort differences that may explain these opposite results, with specific focus on sex differences in treatment and outcomes.METHODS: Multicenter health insurance claims data from a large insurance fund, BARMER, were studied. A homogeneous sample of patients with an index of endovascular revascularization for symptomatic peripheral arterial occlusive disease between 2013 and 2017 was included. Adjusted logistic regression and Cox regression models were used to determine the factors predicting allocation to paclitaxel-coated devices and sex-specific 5-year all-cause mortality, respectively.RESULTS: In total, 13,204 patients (54% females, mean age 74 ± 11 years) were followed for a median of 3.5 years. Females were older (77 vs. 71 years), and had less frequent coronary artery disease (23% vs. 33%), dyslipidemia (44% vs. 50%), and diabetes (29% vs. 41%), as well as being less likely to have a history of smoking (10% vs. 15%) compared with males. Mortality differences were mostly attributable to the female subgroup who were revascularized above the knee (hazard ratio, HR 0.78, 95% CI: 0.64-0.95), while no statistically significant differences were observed in males.CONCLUSIONS: This study found that females treated above the knee benefited from paclitaxel-coated devices, while no differences were found in males. Ongoing and future registries and trials should take sex disparities into account.

U2 - 10.3390/jcm10132978

DO - 10.3390/jcm10132978

M3 - SCORING: Journal article

C2 - 34279461

VL - 10

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 13

M1 - 2978

ER -