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Sex differences in neural correlates of common psychopathological symptoms in early adolescence

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Sex differences in neural correlates of common psychopathological symptoms in early adolescence. / Biondo, Francesca; Thunell, Charlotte Nymberg; Xu, Bing; Chu, Congying; Jia, Tianye; Ing, Alex; Quinlan, Erin Burke; Tay, Nicole; Banaschewski, Tobias; Bokde, Arun L W; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Lemaitre, Hervé; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Millenet, Sabina; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Barker, Edward D; Schumann, Gunter; IMAGEN Consortium.

In: PSYCHOL MED, Vol. 52, No. 14, 10.2022, p. 3086-3096.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Biondo, F, Thunell, CN, Xu, B, Chu, C, Jia, T, Ing, A, Quinlan, EB, Tay, N, Banaschewski, T, Bokde, ALW, Büchel, C, Desrivières, S, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Lemaitre, H, Nees, F, Orfanos, DP, Poustka, L, Millenet, S, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Barker, ED, Schumann, G & IMAGEN Consortium 2022, 'Sex differences in neural correlates of common psychopathological symptoms in early adolescence', PSYCHOL MED, vol. 52, no. 14, pp. 3086-3096. https://doi.org/10.1017/S0033291720005140

APA

Biondo, F., Thunell, C. N., Xu, B., Chu, C., Jia, T., Ing, A., Quinlan, E. B., Tay, N., Banaschewski, T., Bokde, A. L. W., Büchel, C., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J-L., ... IMAGEN Consortium (2022). Sex differences in neural correlates of common psychopathological symptoms in early adolescence. PSYCHOL MED, 52(14), 3086-3096. https://doi.org/10.1017/S0033291720005140

Vancouver

Biondo F, Thunell CN, Xu B, Chu C, Jia T, Ing A et al. Sex differences in neural correlates of common psychopathological symptoms in early adolescence. PSYCHOL MED. 2022 Oct;52(14):3086-3096. https://doi.org/10.1017/S0033291720005140

Bibtex

@article{bc51e9cef976413ebedb4d77029c2166,
title = "Sex differences in neural correlates of common psychopathological symptoms in early adolescence",
abstract = "BACKGROUND: Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interactions are underinvestigated, particularly in adolescence.METHODS: Participants were 14 years of age and part of the IMAGEN study, a large (N = 1526) community-based sample. To test for sex-by-psychopathology interactions in structural grey matter volume (GMV), we used whole-brain, voxel-wise neuroimaging analyses based on robust non-parametric methods. Psychopathological symptom data were derived from the Strengths and Difficulties Questionnaire (SDQ).RESULTS: We found a sex-by-hyperactivity/inattention interaction in four brain clusters: right temporoparietal-opercular region (p < 0.01, Cohen's d = -0.24), bilateral anterior and mid-cingulum (p < 0.05, Cohen's d = -0.18), right cerebellum and fusiform (p < 0.05, Cohen's d = -0.20) and left frontal superior and middle gyri (p < 0.05, Cohen's d = -0.26). Higher symptoms of hyperactivity/inattention were associated with lower GMV in all four brain clusters in boys, and with higher GMV in the temporoparietal-opercular and cerebellar-fusiform clusters in girls.CONCLUSIONS: Using a large, sex-balanced and community-based sample, our study lends support to the idea that externalizing symptoms of hyperactivity/inattention may be associated with different neural structures in male and female adolescents. The brain regions we report have been associated with a myriad of important cognitive functions, in particular, attention, cognitive and motor control, and timing, that are potentially relevant to understand the behavioural manifestations of hyperactive and inattentive symptoms. This study highlights the importance of considering sex in our efforts to uncover mechanisms underlying psychopathology during adolescence.",
author = "Francesca Biondo and Thunell, {Charlotte Nymberg} and Bing Xu and Congying Chu and Tianye Jia and Alex Ing and Quinlan, {Erin Burke} and Nicole Tay and Tobias Banaschewski and Bokde, {Arun L W} and Christian B{\"u}chel and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Herv{\'e} Lemaitre and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Luise Poustka and Sabina Millenet and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Barker, {Edward D} and Gunter Schumann and {IMAGEN Consortium}",
year = "2022",
month = oct,
doi = "10.1017/S0033291720005140",
language = "English",
volume = "52",
pages = "3086--3096",
journal = "PSYCHOL MED",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "14",

}

RIS

TY - JOUR

T1 - Sex differences in neural correlates of common psychopathological symptoms in early adolescence

AU - Biondo, Francesca

AU - Thunell, Charlotte Nymberg

AU - Xu, Bing

AU - Chu, Congying

AU - Jia, Tianye

AU - Ing, Alex

AU - Quinlan, Erin Burke

AU - Tay, Nicole

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Büchel, Christian

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Lemaitre, Hervé

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Poustka, Luise

AU - Millenet, Sabina

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Barker, Edward D

AU - Schumann, Gunter

AU - IMAGEN Consortium

PY - 2022/10

Y1 - 2022/10

N2 - BACKGROUND: Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interactions are underinvestigated, particularly in adolescence.METHODS: Participants were 14 years of age and part of the IMAGEN study, a large (N = 1526) community-based sample. To test for sex-by-psychopathology interactions in structural grey matter volume (GMV), we used whole-brain, voxel-wise neuroimaging analyses based on robust non-parametric methods. Psychopathological symptom data were derived from the Strengths and Difficulties Questionnaire (SDQ).RESULTS: We found a sex-by-hyperactivity/inattention interaction in four brain clusters: right temporoparietal-opercular region (p < 0.01, Cohen's d = -0.24), bilateral anterior and mid-cingulum (p < 0.05, Cohen's d = -0.18), right cerebellum and fusiform (p < 0.05, Cohen's d = -0.20) and left frontal superior and middle gyri (p < 0.05, Cohen's d = -0.26). Higher symptoms of hyperactivity/inattention were associated with lower GMV in all four brain clusters in boys, and with higher GMV in the temporoparietal-opercular and cerebellar-fusiform clusters in girls.CONCLUSIONS: Using a large, sex-balanced and community-based sample, our study lends support to the idea that externalizing symptoms of hyperactivity/inattention may be associated with different neural structures in male and female adolescents. The brain regions we report have been associated with a myriad of important cognitive functions, in particular, attention, cognitive and motor control, and timing, that are potentially relevant to understand the behavioural manifestations of hyperactive and inattentive symptoms. This study highlights the importance of considering sex in our efforts to uncover mechanisms underlying psychopathology during adolescence.

AB - BACKGROUND: Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interactions are underinvestigated, particularly in adolescence.METHODS: Participants were 14 years of age and part of the IMAGEN study, a large (N = 1526) community-based sample. To test for sex-by-psychopathology interactions in structural grey matter volume (GMV), we used whole-brain, voxel-wise neuroimaging analyses based on robust non-parametric methods. Psychopathological symptom data were derived from the Strengths and Difficulties Questionnaire (SDQ).RESULTS: We found a sex-by-hyperactivity/inattention interaction in four brain clusters: right temporoparietal-opercular region (p < 0.01, Cohen's d = -0.24), bilateral anterior and mid-cingulum (p < 0.05, Cohen's d = -0.18), right cerebellum and fusiform (p < 0.05, Cohen's d = -0.20) and left frontal superior and middle gyri (p < 0.05, Cohen's d = -0.26). Higher symptoms of hyperactivity/inattention were associated with lower GMV in all four brain clusters in boys, and with higher GMV in the temporoparietal-opercular and cerebellar-fusiform clusters in girls.CONCLUSIONS: Using a large, sex-balanced and community-based sample, our study lends support to the idea that externalizing symptoms of hyperactivity/inattention may be associated with different neural structures in male and female adolescents. The brain regions we report have been associated with a myriad of important cognitive functions, in particular, attention, cognitive and motor control, and timing, that are potentially relevant to understand the behavioural manifestations of hyperactive and inattentive symptoms. This study highlights the importance of considering sex in our efforts to uncover mechanisms underlying psychopathology during adolescence.

U2 - 10.1017/S0033291720005140

DO - 10.1017/S0033291720005140

M3 - SCORING: Journal article

C2 - 33769238

VL - 52

SP - 3086

EP - 3096

JO - PSYCHOL MED

JF - PSYCHOL MED

SN - 0033-2917

IS - 14

ER -