Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
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Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease. / Bay, Benjamin; Fuh, Marceline M; Rohde, Julia; Worthmann, Anna; Goßling, Alina; Arnold, Natalie; Koester, Lukas; Lorenz, Thiess; Blaum, Christopher; Kirchhof, Paulus; Blankenberg, Stefan; Seiffert, Moritz; Brunner, Fabian J; Waldeyer, Christoph; Heeren, Joerg.
In: LIPIDS HEALTH DIS, Vol. 23, No. 1, 26.06.2024, p. 197.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
AU - Bay, Benjamin
AU - Fuh, Marceline M
AU - Rohde, Julia
AU - Worthmann, Anna
AU - Goßling, Alina
AU - Arnold, Natalie
AU - Koester, Lukas
AU - Lorenz, Thiess
AU - Blaum, Christopher
AU - Kirchhof, Paulus
AU - Blankenberg, Stefan
AU - Seiffert, Moritz
AU - Brunner, Fabian J
AU - Waldeyer, Christoph
AU - Heeren, Joerg
N1 - © 2024. The Author(s).
PY - 2024/6/26
Y1 - 2024/6/26
N2 - BACKGROUND: Lipids, including phospholipids and bile acids, exert various signaling effects and are thought to contribute to the development of coronary artery disease (CAD). Here, we aimed to compare lipidomic and bile acid profiles in the blood of patients with and without CAD stratified by sex.METHODS: From 2015 to 2022, 3,012 patients who underwent coronary angiography were recruited in the INTERCATH cohort. From the overall cohort, subgroups were defined using patient characteristics such as CAD vs. no CAD, 1st vs. 3rd tertile of LDL-c, and female vs. male sex. Hereafter, a matching algorithm based on age, BMI, hypertension status, diabetes mellitus status, smoking status, the Mediterranean diet score, and the intake of statins, triglycerides, HDL-c and hs-CRP in a 1:1 ratio was implemented. Lipidomic analyses of stored blood samples using the Lipidyzer platform (SCIEX) and bile acid analysis using liquid chromatography with tandem mass spectrometry (LC‒MS/MS) were carried out.RESULTS: A total of 177 matched individuals were analyzed; the median ages were 73.5 years (25th and 75th percentile: 64.1, 78.2) and 71.9 years (65.7, 77.2) for females and males with CAD, respectively, and 67.6 years (58.3, 75.3) and 69.2 years (59.8, 76.8) for females and males without CAD, respectively. Further baseline characteristics, including cardiovascular risk factors, were balanced between the groups. Women with CAD had decreased levels of phosphatidylcholine and diacylglycerol, while no differences in bile acid profiles were detected in comparison to those of female patients without CAD. In contrast, in male patients with CAD, decreased concentrations of the secondary bile acid species glycolithocholic and lithocholic acid, as well as altered levels of specific lipids, were detected compared to those in males without CAD. Notably, male patients with low LDL-c and CAD had significantly greater concentrations of various phospholipid species, particularly plasmalogens, compared to those in high LDL-c subgroup.CONCLUSIONS: We present hypothesis-generating data on sex-specific lipidomic patterns and bile acid profiles in CAD patients. The data suggest that altered lipid and bile acid composition might contribute to CAD development and/or progression, helping to understand the different disease trajectories of CAD in women and men.REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT04936438 , Unique identifier: NCT04936438.
AB - BACKGROUND: Lipids, including phospholipids and bile acids, exert various signaling effects and are thought to contribute to the development of coronary artery disease (CAD). Here, we aimed to compare lipidomic and bile acid profiles in the blood of patients with and without CAD stratified by sex.METHODS: From 2015 to 2022, 3,012 patients who underwent coronary angiography were recruited in the INTERCATH cohort. From the overall cohort, subgroups were defined using patient characteristics such as CAD vs. no CAD, 1st vs. 3rd tertile of LDL-c, and female vs. male sex. Hereafter, a matching algorithm based on age, BMI, hypertension status, diabetes mellitus status, smoking status, the Mediterranean diet score, and the intake of statins, triglycerides, HDL-c and hs-CRP in a 1:1 ratio was implemented. Lipidomic analyses of stored blood samples using the Lipidyzer platform (SCIEX) and bile acid analysis using liquid chromatography with tandem mass spectrometry (LC‒MS/MS) were carried out.RESULTS: A total of 177 matched individuals were analyzed; the median ages were 73.5 years (25th and 75th percentile: 64.1, 78.2) and 71.9 years (65.7, 77.2) for females and males with CAD, respectively, and 67.6 years (58.3, 75.3) and 69.2 years (59.8, 76.8) for females and males without CAD, respectively. Further baseline characteristics, including cardiovascular risk factors, were balanced between the groups. Women with CAD had decreased levels of phosphatidylcholine and diacylglycerol, while no differences in bile acid profiles were detected in comparison to those of female patients without CAD. In contrast, in male patients with CAD, decreased concentrations of the secondary bile acid species glycolithocholic and lithocholic acid, as well as altered levels of specific lipids, were detected compared to those in males without CAD. Notably, male patients with low LDL-c and CAD had significantly greater concentrations of various phospholipid species, particularly plasmalogens, compared to those in high LDL-c subgroup.CONCLUSIONS: We present hypothesis-generating data on sex-specific lipidomic patterns and bile acid profiles in CAD patients. The data suggest that altered lipid and bile acid composition might contribute to CAD development and/or progression, helping to understand the different disease trajectories of CAD in women and men.REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT04936438 , Unique identifier: NCT04936438.
KW - Aged
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Bile Acids and Salts/blood
KW - Cholesterol, HDL/blood
KW - Cholesterol, LDL/blood
KW - Coronary Artery Disease/blood
KW - Lipidomics
KW - Sex Characteristics
KW - Sex Factors
KW - Tandem Mass Spectrometry
KW - Triglycerides/blood
KW - Cohort Studies
U2 - 10.1186/s12944-024-02184-z
DO - 10.1186/s12944-024-02184-z
M3 - SCORING: Journal article
C2 - 38926753
VL - 23
SP - 197
JO - LIPIDS HEALTH DIS
JF - LIPIDS HEALTH DIS
SN - 1476-511X
IS - 1
ER -