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Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade

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Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade. / Guihaire, Julien; Deuse, Tobias; Wang, Dong; Fadel, Elie; Reichenspurner, Hermann; Schrepfer, Sonja.

In: BIOMED RES INT , Vol. 2015, 2015, p. 765292.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Guihaire, J, Deuse, T, Wang, D, Fadel, E, Reichenspurner, H & Schrepfer, S 2015, 'Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade', BIOMED RES INT , vol. 2015, pp. 765292. https://doi.org/10.1155/2015/765292

APA

Guihaire, J., Deuse, T., Wang, D., Fadel, E., Reichenspurner, H., & Schrepfer, S. (2015). Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade. BIOMED RES INT , 2015, 765292. https://doi.org/10.1155/2015/765292

Vancouver

Guihaire J, Deuse T, Wang D, Fadel E, Reichenspurner H, Schrepfer S. Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade. BIOMED RES INT . 2015;2015:765292. https://doi.org/10.1155/2015/765292

Bibtex

@article{8b86d80109714048b71ebc367d1ea9f3,
title = "Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade",
abstract = "BACKGROUND: The epidemiology of pulmonary hypertension (PH) is characterized by a female preponderance, whereas males share higher severity of the disease.OBJECTIVE: To compare the severity of experimental PH between male and female athymic rats.METHODS: PH was induced in 11 male and 11 female athymic rats (resp., SU_M and SU_F groups) using an inhibitor of VEGF-receptors I and II, semaxanib (40 mg/kg). After 28 days, right ventricular (RV) remodeling, systolic function, and hemodynamics were measured using echocardiography and a pressure-volume admittance catheter. Morphometric analyses of lung vasculature and RV myocardium were performed.RESULTS: Four weeks after semaxanib injection, RV end-systolic pressure was higher in SU_M than in SU_F. Males developed marked RV enlargement and systolic dysfunction compared to females. Impairment of RV-PA coupling efficiency was observed only in SU_M. The smooth muscle cells of the pulmonary arteries switched from a contractile state to a dedifferentiated state only in males.CONCLUSIONS: Female athymic rats were protected against the development of severe PH. RV-PA coupling was preserved in females through limitation of pulmonary artery muscularization. Control of smooth muscle cells plasticity may be a promising therapeutic approach to reverse established vascular remodeling in PH patients.",
keywords = "Animals, Echo-Planar Imaging, Female, Fluorescent Antibody Technique, Heart Ventricles/pathology, Hemodynamics, Hypertension, Pulmonary/immunology, Male, Pulmonary Artery/pathology, Rats, Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors, Sex Characteristics",
author = "Julien Guihaire and Tobias Deuse and Dong Wang and Elie Fadel and Hermann Reichenspurner and Sonja Schrepfer",
year = "2015",
doi = "10.1155/2015/765292",
language = "English",
volume = "2015",
pages = "765292",
journal = "BIOMED RES INT ",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade

AU - Guihaire, Julien

AU - Deuse, Tobias

AU - Wang, Dong

AU - Fadel, Elie

AU - Reichenspurner, Hermann

AU - Schrepfer, Sonja

PY - 2015

Y1 - 2015

N2 - BACKGROUND: The epidemiology of pulmonary hypertension (PH) is characterized by a female preponderance, whereas males share higher severity of the disease.OBJECTIVE: To compare the severity of experimental PH between male and female athymic rats.METHODS: PH was induced in 11 male and 11 female athymic rats (resp., SU_M and SU_F groups) using an inhibitor of VEGF-receptors I and II, semaxanib (40 mg/kg). After 28 days, right ventricular (RV) remodeling, systolic function, and hemodynamics were measured using echocardiography and a pressure-volume admittance catheter. Morphometric analyses of lung vasculature and RV myocardium were performed.RESULTS: Four weeks after semaxanib injection, RV end-systolic pressure was higher in SU_M than in SU_F. Males developed marked RV enlargement and systolic dysfunction compared to females. Impairment of RV-PA coupling efficiency was observed only in SU_M. The smooth muscle cells of the pulmonary arteries switched from a contractile state to a dedifferentiated state only in males.CONCLUSIONS: Female athymic rats were protected against the development of severe PH. RV-PA coupling was preserved in females through limitation of pulmonary artery muscularization. Control of smooth muscle cells plasticity may be a promising therapeutic approach to reverse established vascular remodeling in PH patients.

AB - BACKGROUND: The epidemiology of pulmonary hypertension (PH) is characterized by a female preponderance, whereas males share higher severity of the disease.OBJECTIVE: To compare the severity of experimental PH between male and female athymic rats.METHODS: PH was induced in 11 male and 11 female athymic rats (resp., SU_M and SU_F groups) using an inhibitor of VEGF-receptors I and II, semaxanib (40 mg/kg). After 28 days, right ventricular (RV) remodeling, systolic function, and hemodynamics were measured using echocardiography and a pressure-volume admittance catheter. Morphometric analyses of lung vasculature and RV myocardium were performed.RESULTS: Four weeks after semaxanib injection, RV end-systolic pressure was higher in SU_M than in SU_F. Males developed marked RV enlargement and systolic dysfunction compared to females. Impairment of RV-PA coupling efficiency was observed only in SU_M. The smooth muscle cells of the pulmonary arteries switched from a contractile state to a dedifferentiated state only in males.CONCLUSIONS: Female athymic rats were protected against the development of severe PH. RV-PA coupling was preserved in females through limitation of pulmonary artery muscularization. Control of smooth muscle cells plasticity may be a promising therapeutic approach to reverse established vascular remodeling in PH patients.

KW - Animals

KW - Echo-Planar Imaging

KW - Female

KW - Fluorescent Antibody Technique

KW - Heart Ventricles/pathology

KW - Hemodynamics

KW - Hypertension, Pulmonary/immunology

KW - Male

KW - Pulmonary Artery/pathology

KW - Rats

KW - Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors

KW - Sex Characteristics

U2 - 10.1155/2015/765292

DO - 10.1155/2015/765292

M3 - SCORING: Journal article

C2 - 26421302

VL - 2015

SP - 765292

JO - BIOMED RES INT

JF - BIOMED RES INT

SN - 2314-6133

ER -