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Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence

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Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence. / White, Thomas P; Loth, Eva; Krabbendam, Lydia; Rubia, Katya; Whelan, Robert; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun Lw; Büchel, Christian; Conrod, Patricia; Flor, Herta; Frouin, Vincent; Heinz, Andreas; Garavan, Hugh; Gowland, Penny; Ittermann, Bernd; Lawrence, Claire; Mann, Karl; Paillère, Marie-Laure; Nees, Frauke; Paus, Tomas; Pausova, Zdenka; Rietschel, Marcella; Robbins, Trevor; Fauth-Bühler, Mira; Smolka, Michael N; Gallinat, Jürgen; Shergill, Sukhwinder S; Schumann, Gunter.

In: NEUROPSYCHOPHARMACOL, Vol. 39, No. 11, 2014, p. 2560-2569.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

White, TP, Loth, E, Krabbendam, L, Rubia, K, Whelan, R, Banaschewski, T, Barker, GJ, Bokde, AL, Büchel, C, Conrod, P, Flor, H, Frouin, V, Heinz, A, Garavan, H, Gowland, P, Ittermann, B, Lawrence, C, Mann, K, Paillère, M-L, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Robbins, T, Fauth-Bühler, M, Smolka, MN, Gallinat, J, Shergill, SS & Schumann, G 2014, 'Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence', NEUROPSYCHOPHARMACOL, vol. 39, no. 11, pp. 2560-2569. https://doi.org/10.1038/npp.2014.107

APA

White, T. P., Loth, E., Krabbendam, L., Rubia, K., Whelan, R., Banaschewski, T., Barker, G. J., Bokde, A. L., Büchel, C., Conrod, P., Flor, H., Frouin, V., Heinz, A., Garavan, H., Gowland, P., Ittermann, B., Lawrence, C., Mann, K., Paillère, M-L., ... Schumann, G. (2014). Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence. NEUROPSYCHOPHARMACOL, 39(11), 2560-2569. https://doi.org/10.1038/npp.2014.107

Vancouver

White TP, Loth E, Krabbendam L, Rubia K, Whelan R, Banaschewski T et al. Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence. NEUROPSYCHOPHARMACOL. 2014;39(11):2560-2569. https://doi.org/10.1038/npp.2014.107

Bibtex

@article{b4d81d66c30c493b8c20f8140306ec76,
title = "Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence",
abstract = "Catecholamine-0-methyl-transferase (COMT) gene variation effects on prefrontal blood oxygenation-level dependent (BOLD) activation are robust; however, despite observations that COMT is oestrogenically catabolised, sex differences in its prefrontal repercussions remain unclear. Here, in a large sample of healthy adolescents stratified by sex and Val(158)Met genotype (n=1133) we examine BOLD responses during performance of the stop-signal task in right-hemispheric prefrontal regions fundamental to inhibitory control. A significant sex-by-genotype interaction was observed in pre-SMA during successful-inhibition trials and in both pre-SMA and inferior frontal cortex during failed-inhibition trials with Val-homozygotes displaying elevated activation compared to other genotypes in males but not in females. BOLD activation in the same regions significantly mediated the relationship between COMT genotype and inhibitory proficiency as indexed by stop-signal reaction time in males alone. These sexually-dimorphic effects of COMT on inhibitory brain activation have important implications for our understanding of the contrasting patterns of prefrontally-governed psychopathology observed in males and females.Neuropsychopharmacology accepted article preview online, 13 May 2014; doi:10.1038/npp.2014.107.",
author = "White, {Thomas P} and Eva Loth and Lydia Krabbendam and Katya Rubia and Robert Whelan and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun Lw} and Christian B{\"u}chel and Patricia Conrod and Herta Flor and Vincent Frouin and Andreas Heinz and Hugh Garavan and Penny Gowland and Bernd Ittermann and Claire Lawrence and Karl Mann and Marie-Laure Paill{\`e}re and Frauke Nees and Tomas Paus and Zdenka Pausova and Marcella Rietschel and Trevor Robbins and Mira Fauth-B{\"u}hler and Smolka, {Michael N} and J{\"u}rgen Gallinat and Shergill, {Sukhwinder S} and Gunter Schumann",
year = "2014",
doi = "10.1038/npp.2014.107",
language = "English",
volume = "39",
pages = "2560--2569",
journal = "NEUROPSYCHOPHARMACOL",
issn = "0893-133X",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence

AU - White, Thomas P

AU - Loth, Eva

AU - Krabbendam, Lydia

AU - Rubia, Katya

AU - Whelan, Robert

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun Lw

AU - Büchel, Christian

AU - Conrod, Patricia

AU - Flor, Herta

AU - Frouin, Vincent

AU - Heinz, Andreas

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Ittermann, Bernd

AU - Lawrence, Claire

AU - Mann, Karl

AU - Paillère, Marie-Laure

AU - Nees, Frauke

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Rietschel, Marcella

AU - Robbins, Trevor

AU - Fauth-Bühler, Mira

AU - Smolka, Michael N

AU - Gallinat, Jürgen

AU - Shergill, Sukhwinder S

AU - Schumann, Gunter

PY - 2014

Y1 - 2014

N2 - Catecholamine-0-methyl-transferase (COMT) gene variation effects on prefrontal blood oxygenation-level dependent (BOLD) activation are robust; however, despite observations that COMT is oestrogenically catabolised, sex differences in its prefrontal repercussions remain unclear. Here, in a large sample of healthy adolescents stratified by sex and Val(158)Met genotype (n=1133) we examine BOLD responses during performance of the stop-signal task in right-hemispheric prefrontal regions fundamental to inhibitory control. A significant sex-by-genotype interaction was observed in pre-SMA during successful-inhibition trials and in both pre-SMA and inferior frontal cortex during failed-inhibition trials with Val-homozygotes displaying elevated activation compared to other genotypes in males but not in females. BOLD activation in the same regions significantly mediated the relationship between COMT genotype and inhibitory proficiency as indexed by stop-signal reaction time in males alone. These sexually-dimorphic effects of COMT on inhibitory brain activation have important implications for our understanding of the contrasting patterns of prefrontally-governed psychopathology observed in males and females.Neuropsychopharmacology accepted article preview online, 13 May 2014; doi:10.1038/npp.2014.107.

AB - Catecholamine-0-methyl-transferase (COMT) gene variation effects on prefrontal blood oxygenation-level dependent (BOLD) activation are robust; however, despite observations that COMT is oestrogenically catabolised, sex differences in its prefrontal repercussions remain unclear. Here, in a large sample of healthy adolescents stratified by sex and Val(158)Met genotype (n=1133) we examine BOLD responses during performance of the stop-signal task in right-hemispheric prefrontal regions fundamental to inhibitory control. A significant sex-by-genotype interaction was observed in pre-SMA during successful-inhibition trials and in both pre-SMA and inferior frontal cortex during failed-inhibition trials with Val-homozygotes displaying elevated activation compared to other genotypes in males but not in females. BOLD activation in the same regions significantly mediated the relationship between COMT genotype and inhibitory proficiency as indexed by stop-signal reaction time in males alone. These sexually-dimorphic effects of COMT on inhibitory brain activation have important implications for our understanding of the contrasting patterns of prefrontally-governed psychopathology observed in males and females.Neuropsychopharmacology accepted article preview online, 13 May 2014; doi:10.1038/npp.2014.107.

U2 - 10.1038/npp.2014.107

DO - 10.1038/npp.2014.107

M3 - SCORING: Journal article

C2 - 24820538

VL - 39

SP - 2560

EP - 2569

JO - NEUROPSYCHOPHARMACOL

JF - NEUROPSYCHOPHARMACOL

SN - 0893-133X

IS - 11

ER -