Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5

Mariëlle Kloosterman; Winnie Chua; Larissa Fabritz; Hussein R Al-Khalidi; Ulrich Schotten; Jens C Nielsen; Jonathan P Piccini; Luigi Di Biase; Karl Georg Häusler; Derick Todd; Lluis Mont; Isabelle C Van Gelder; Paulus Kirchhof; AXAFA-AFNET 5 investigators

doi:10.1093/europace/euaa015

Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5

Standard

Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5. / Kloosterman, Mariëlle; Chua, Winnie; Fabritz, Larissa; Al-Khalidi, Hussein R; Schotten, Ulrich; Nielsen, Jens C; Piccini, Jonathan P; Di Biase, Luigi; Häusler, Karl Georg; Todd, Derick; Mont, Lluis; Van Gelder, Isabelle C; Kirchhof, Paulus; AXAFA-AFNET 5 investigators.

In: EUROPACE, Vol. 22, No. 7, 01.07.2020, p. 1026-1035.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kloosterman, M, Chua, W, Fabritz, L, Al-Khalidi, HR, Schotten, U, Nielsen, JC, Piccini, JP, Di Biase, L, Häusler, KG, Todd, D, Mont, L, Van Gelder, IC, Kirchhof, P & AXAFA-AFNET 5 investigators 2020, 'Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5', EUROPACE, vol. 22, no. 7, pp. 1026-1035. https://doi.org/10.1093/europace/euaa015

APA

Kloosterman, M., Chua, W., Fabritz, L., Al-Khalidi, H. R., Schotten, U., Nielsen, J. C., Piccini, J. P., Di Biase, L., Häusler, K. G., Todd, D., Mont, L., Van Gelder, I. C., Kirchhof, P., & AXAFA-AFNET 5 investigators (2020). Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5. EUROPACE, 22(7), 1026-1035. https://doi.org/10.1093/europace/euaa015

Vancouver

Kloosterman M, Chua W, Fabritz L, Al-Khalidi HR, Schotten U, Nielsen JC et al. Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5. EUROPACE. 2020 Jul 1;22(7):1026-1035. https://doi.org/10.1093/europace/euaa015

Bibtex

@article{2773654a13f14553982a94e4a1fee6ac,

title = "Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5",

abstract = "AIMS: Study sex-differences in efficacy and safety of atrial fibrillation (AF) ablation.METHODS AND RESULTS: We assessed first AF ablation outcomes on continuous anticoagulation in 633 patients [209 (33%) women and 424 (67%) men] in a pre-specified subgroup analysis of the AXAFA-AFNET 5 trial. We compared the primary outcome (death, stroke or transient ischaemic attack, or major bleeding) and secondary outcomes [change in quality of life (QoL) and cognitive function] 3 months after ablation. Women were older (66 vs. 63 years, P < 0.001), more often symptomatic, had lower QoL and a longer history of AF. No sex differences in ablation procedure were found. Women stayed in hospital longer than men (2.1 ± 2.3 vs. 1.6 ± 1.3 days, P = 0.004). The primary outcome occurred in 19 (9.1%) women and 26 (6.1%) men, P = 0.19. Women experienced more bleeding events requiring medical attention (5.7% vs. 2.1%, P = 0.03), while rates of tamponade (1.0% vs. 1.2%) or intracranial haemorrhage (0.5% vs. 0%) did not differ. Improvement in QoL after ablation was similar between the sexes [12-item Short Form Health Survey (SF-12) physical 5.1% and 5.9%, P = 0.26; and SF-12 mental 3.7% and 1.6%, P = 0.17]. At baseline, mild cognitive impairment according to the Montreal Cognitive Assessment (MoCA) was present in 65 (32%) women and 123 (30%) men and declined to 23% for both sexes at end of follow-up.CONCLUSION: Women and men experience similar improvement in QoL and MoCA score after AF ablation on continuous anticoagulation. Longer hospital stay, a trend towards more nuisance bleeds, and a lower overall QoL in women were the main differences observed.",

keywords = "Atrial Fibrillation/diagnosis, Catheter Ablation/adverse effects, Female, Humans, Male, Quality of Life, Sex Characteristics, Stroke/epidemiology, Treatment Outcome",

author = "Mari{\"e}lle Kloosterman and Winnie Chua and Larissa Fabritz and Al-Khalidi, {Hussein R} and Ulrich Schotten and Nielsen, {Jens C} and Piccini, {Jonathan P} and {Di Biase}, Luigi and H{\"a}usler, {Karl Georg} and Derick Todd and Lluis Mont and {Van Gelder}, {Isabelle C} and Paulus Kirchhof and {AXAFA-AFNET 5 investigators}",

year = "2020",

month = jul,

day = "1",

doi = "10.1093/europace/euaa015",

language = "English",

volume = "22",

pages = "1026--1035",

journal = "EUROPACE",

issn = "1099-5129",

publisher = "Oxford University Press",

number = "7",

}

RIS

TY - JOUR

T1 - Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5

AU - Kloosterman, Mariëlle

AU - Chua, Winnie

AU - Fabritz, Larissa

AU - Al-Khalidi, Hussein R

AU - Schotten, Ulrich

AU - Nielsen, Jens C

AU - Piccini, Jonathan P

AU - Di Biase, Luigi

AU - Häusler, Karl Georg

AU - Todd, Derick

AU - Mont, Lluis

AU - Van Gelder, Isabelle C

AU - Kirchhof, Paulus

AU - AXAFA-AFNET 5 investigators

PY - 2020/7/1

Y1 - 2020/7/1

N2 - AIMS: Study sex-differences in efficacy and safety of atrial fibrillation (AF) ablation.METHODS AND RESULTS: We assessed first AF ablation outcomes on continuous anticoagulation in 633 patients [209 (33%) women and 424 (67%) men] in a pre-specified subgroup analysis of the AXAFA-AFNET 5 trial. We compared the primary outcome (death, stroke or transient ischaemic attack, or major bleeding) and secondary outcomes [change in quality of life (QoL) and cognitive function] 3 months after ablation. Women were older (66 vs. 63 years, P < 0.001), more often symptomatic, had lower QoL and a longer history of AF. No sex differences in ablation procedure were found. Women stayed in hospital longer than men (2.1 ± 2.3 vs. 1.6 ± 1.3 days, P = 0.004). The primary outcome occurred in 19 (9.1%) women and 26 (6.1%) men, P = 0.19. Women experienced more bleeding events requiring medical attention (5.7% vs. 2.1%, P = 0.03), while rates of tamponade (1.0% vs. 1.2%) or intracranial haemorrhage (0.5% vs. 0%) did not differ. Improvement in QoL after ablation was similar between the sexes [12-item Short Form Health Survey (SF-12) physical 5.1% and 5.9%, P = 0.26; and SF-12 mental 3.7% and 1.6%, P = 0.17]. At baseline, mild cognitive impairment according to the Montreal Cognitive Assessment (MoCA) was present in 65 (32%) women and 123 (30%) men and declined to 23% for both sexes at end of follow-up.CONCLUSION: Women and men experience similar improvement in QoL and MoCA score after AF ablation on continuous anticoagulation. Longer hospital stay, a trend towards more nuisance bleeds, and a lower overall QoL in women were the main differences observed.

AB - AIMS: Study sex-differences in efficacy and safety of atrial fibrillation (AF) ablation.METHODS AND RESULTS: We assessed first AF ablation outcomes on continuous anticoagulation in 633 patients [209 (33%) women and 424 (67%) men] in a pre-specified subgroup analysis of the AXAFA-AFNET 5 trial. We compared the primary outcome (death, stroke or transient ischaemic attack, or major bleeding) and secondary outcomes [change in quality of life (QoL) and cognitive function] 3 months after ablation. Women were older (66 vs. 63 years, P < 0.001), more often symptomatic, had lower QoL and a longer history of AF. No sex differences in ablation procedure were found. Women stayed in hospital longer than men (2.1 ± 2.3 vs. 1.6 ± 1.3 days, P = 0.004). The primary outcome occurred in 19 (9.1%) women and 26 (6.1%) men, P = 0.19. Women experienced more bleeding events requiring medical attention (5.7% vs. 2.1%, P = 0.03), while rates of tamponade (1.0% vs. 1.2%) or intracranial haemorrhage (0.5% vs. 0%) did not differ. Improvement in QoL after ablation was similar between the sexes [12-item Short Form Health Survey (SF-12) physical 5.1% and 5.9%, P = 0.26; and SF-12 mental 3.7% and 1.6%, P = 0.17]. At baseline, mild cognitive impairment according to the Montreal Cognitive Assessment (MoCA) was present in 65 (32%) women and 123 (30%) men and declined to 23% for both sexes at end of follow-up.CONCLUSION: Women and men experience similar improvement in QoL and MoCA score after AF ablation on continuous anticoagulation. Longer hospital stay, a trend towards more nuisance bleeds, and a lower overall QoL in women were the main differences observed.

KW - Atrial Fibrillation/diagnosis

KW - Catheter Ablation/adverse effects

KW - Female

KW - Humans

KW - Male

KW - Quality of Life

KW - Sex Characteristics

KW - Stroke/epidemiology

KW - Treatment Outcome

U2 - 10.1093/europace/euaa015

DO - 10.1093/europace/euaa015

M3 - SCORING: Journal article

C2 - 32142113

VL - 22

SP - 1026

EP - 1035

JO - EUROPACE

JF - EUROPACE

SN - 1099-5129

IS - 7

ER -