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Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry

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Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry. / Sugianto, Rizky I; Schmidt, Bernhard M W; Memaran, Nima; Duzova, Ali; Topaloglu, Rezan; Seeman, Tomas; König, Sabine; Dello Strologo, Luca; Murer, Luisa; Özçakar, Zeynep Birsin; Bald, Martin; Shenoy, Mohan; Buescher, Anja; Hoyer, Peter F; Pohl, Michael; Billing, Heiko; Oh, Jun; Staude, Hagen; Pohl, Martin; Genc, Gurkan; Klaus, Günter; Alparslan, Caner; Grenda, Ryszard; Rubik, Jacek; Krupka, Kai; Tönshoff, Burkhard; Wühl, Elke; Melk, Anette.

In: PEDIATR NEPHROL, Vol. 35, No. 3, 03.2020, p. 415-426.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sugianto, RI, Schmidt, BMW, Memaran, N, Duzova, A, Topaloglu, R, Seeman, T, König, S, Dello Strologo, L, Murer, L, Özçakar, ZB, Bald, M, Shenoy, M, Buescher, A, Hoyer, PF, Pohl, M, Billing, H, Oh, J, Staude, H, Pohl, M, Genc, G, Klaus, G, Alparslan, C, Grenda, R, Rubik, J, Krupka, K, Tönshoff, B, Wühl, E & Melk, A 2020, 'Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry', PEDIATR NEPHROL, vol. 35, no. 3, pp. 415-426. https://doi.org/10.1007/s00467-019-04395-4

APA

Sugianto, R. I., Schmidt, B. M. W., Memaran, N., Duzova, A., Topaloglu, R., Seeman, T., König, S., Dello Strologo, L., Murer, L., Özçakar, Z. B., Bald, M., Shenoy, M., Buescher, A., Hoyer, P. F., Pohl, M., Billing, H., Oh, J., Staude, H., Pohl, M., ... Melk, A. (2020). Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry. PEDIATR NEPHROL, 35(3), 415-426. https://doi.org/10.1007/s00467-019-04395-4

Vancouver

Sugianto RI, Schmidt BMW, Memaran N, Duzova A, Topaloglu R, Seeman T et al. Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry. PEDIATR NEPHROL. 2020 Mar;35(3):415-426. https://doi.org/10.1007/s00467-019-04395-4

Bibtex

@article{8314d925f0634715ace97eae550d819b,
title = "Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry",
abstract = "BACKGROUND: High prevalence of arterial hypertension is known in pediatric renal transplant patients, but how blood pressure (BP) distribution and control differ between age groups and whether sex and age interact and potentially impact BP after transplantation have not been investigated.METHODS: This retrospective analysis included 336 pediatric renal transplant recipients (62% males) from the Cooperative European Pediatric Renal Transplant Initiative Registry (CERTAIN) with complete BP measurement at discharge and 1, 2 and 3 years post-transplant.RESULTS: At discharge and 3 years post-transplant, arterial hypertension was highly prevalent (84% and 77%); antihypertensive drugs were used in 73% and 68% of the patients. 27% suffered from uncontrolled and 9% from untreated hypertension at 3 years post-transplant. Children transplanted at age < 5 years showed sustained high systolic BP z-score and received consistently less antihypertensive treatment over time. Younger age, shorter time since transplantation, male sex, higher body mass index (BMI), high cyclosporine A (CSA) trough levels, and a primary renal disease other than congenital anomalies of the kidney and urinary tract (CAKUT) were significantly associated with higher systolic BP z-score. Sex-stratified analysis revealed a significant association between high CSA and higher systolic BP in older girls that likely had started puberty already. An association between BP and estimated glomerular filtration rate was not detected.CONCLUSIONS: BP control during the first 3 years was poor in this large European cohort. The description of age- and sex-specific risk profiles identified certain recipient groups that may benefit from more frequent BP monitoring (i.e. young children) or different choices of immunosuppression (i.e. older girls).",
author = "Sugianto, {Rizky I} and Schmidt, {Bernhard M W} and Nima Memaran and Ali Duzova and Rezan Topaloglu and Tomas Seeman and Sabine K{\"o}nig and {Dello Strologo}, Luca and Luisa Murer and {\"O}z{\c c}akar, {Zeynep Birsin} and Martin Bald and Mohan Shenoy and Anja Buescher and Hoyer, {Peter F} and Michael Pohl and Heiko Billing and Jun Oh and Hagen Staude and Martin Pohl and Gurkan Genc and G{\"u}nter Klaus and Caner Alparslan and Ryszard Grenda and Jacek Rubik and Kai Krupka and Burkhard T{\"o}nshoff and Elke W{\"u}hl and Anette Melk",
year = "2020",
month = mar,
doi = "10.1007/s00467-019-04395-4",
language = "English",
volume = "35",
pages = "415--426",
journal = "PEDIATR NEPHROL",
issn = "0931-041X",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry

AU - Sugianto, Rizky I

AU - Schmidt, Bernhard M W

AU - Memaran, Nima

AU - Duzova, Ali

AU - Topaloglu, Rezan

AU - Seeman, Tomas

AU - König, Sabine

AU - Dello Strologo, Luca

AU - Murer, Luisa

AU - Özçakar, Zeynep Birsin

AU - Bald, Martin

AU - Shenoy, Mohan

AU - Buescher, Anja

AU - Hoyer, Peter F

AU - Pohl, Michael

AU - Billing, Heiko

AU - Oh, Jun

AU - Staude, Hagen

AU - Pohl, Martin

AU - Genc, Gurkan

AU - Klaus, Günter

AU - Alparslan, Caner

AU - Grenda, Ryszard

AU - Rubik, Jacek

AU - Krupka, Kai

AU - Tönshoff, Burkhard

AU - Wühl, Elke

AU - Melk, Anette

PY - 2020/3

Y1 - 2020/3

N2 - BACKGROUND: High prevalence of arterial hypertension is known in pediatric renal transplant patients, but how blood pressure (BP) distribution and control differ between age groups and whether sex and age interact and potentially impact BP after transplantation have not been investigated.METHODS: This retrospective analysis included 336 pediatric renal transplant recipients (62% males) from the Cooperative European Pediatric Renal Transplant Initiative Registry (CERTAIN) with complete BP measurement at discharge and 1, 2 and 3 years post-transplant.RESULTS: At discharge and 3 years post-transplant, arterial hypertension was highly prevalent (84% and 77%); antihypertensive drugs were used in 73% and 68% of the patients. 27% suffered from uncontrolled and 9% from untreated hypertension at 3 years post-transplant. Children transplanted at age < 5 years showed sustained high systolic BP z-score and received consistently less antihypertensive treatment over time. Younger age, shorter time since transplantation, male sex, higher body mass index (BMI), high cyclosporine A (CSA) trough levels, and a primary renal disease other than congenital anomalies of the kidney and urinary tract (CAKUT) were significantly associated with higher systolic BP z-score. Sex-stratified analysis revealed a significant association between high CSA and higher systolic BP in older girls that likely had started puberty already. An association between BP and estimated glomerular filtration rate was not detected.CONCLUSIONS: BP control during the first 3 years was poor in this large European cohort. The description of age- and sex-specific risk profiles identified certain recipient groups that may benefit from more frequent BP monitoring (i.e. young children) or different choices of immunosuppression (i.e. older girls).

AB - BACKGROUND: High prevalence of arterial hypertension is known in pediatric renal transplant patients, but how blood pressure (BP) distribution and control differ between age groups and whether sex and age interact and potentially impact BP after transplantation have not been investigated.METHODS: This retrospective analysis included 336 pediatric renal transplant recipients (62% males) from the Cooperative European Pediatric Renal Transplant Initiative Registry (CERTAIN) with complete BP measurement at discharge and 1, 2 and 3 years post-transplant.RESULTS: At discharge and 3 years post-transplant, arterial hypertension was highly prevalent (84% and 77%); antihypertensive drugs were used in 73% and 68% of the patients. 27% suffered from uncontrolled and 9% from untreated hypertension at 3 years post-transplant. Children transplanted at age < 5 years showed sustained high systolic BP z-score and received consistently less antihypertensive treatment over time. Younger age, shorter time since transplantation, male sex, higher body mass index (BMI), high cyclosporine A (CSA) trough levels, and a primary renal disease other than congenital anomalies of the kidney and urinary tract (CAKUT) were significantly associated with higher systolic BP z-score. Sex-stratified analysis revealed a significant association between high CSA and higher systolic BP in older girls that likely had started puberty already. An association between BP and estimated glomerular filtration rate was not detected.CONCLUSIONS: BP control during the first 3 years was poor in this large European cohort. The description of age- and sex-specific risk profiles identified certain recipient groups that may benefit from more frequent BP monitoring (i.e. young children) or different choices of immunosuppression (i.e. older girls).

U2 - 10.1007/s00467-019-04395-4

DO - 10.1007/s00467-019-04395-4

M3 - SCORING: Journal article

C2 - 31811541

VL - 35

SP - 415

EP - 426

JO - PEDIATR NEPHROL

JF - PEDIATR NEPHROL

SN - 0931-041X

IS - 3

ER -