Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months
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Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months. / Steinbeis, Fridolin; Thibeault, Charlotte; Doellinger, Felix; Ring, Raphaela Maria; Mittermaier, Mirja; Ruwwe-Glösenkamp, Christoph; Alius, Florian; Knape, Philipp; Meyer, Hans-Jakob; Lippert, Lena Johanna; Helbig, Elisa Theresa; Grund, Daniel; Temmesfeld-Wollbrück, Bettina; Suttorp, Norbert; Sander, Leif Erik; Kurth, Florian; Penzkofer, Tobias; Witzenrath, Martin; Zoller, Thomas.
In: RESP MED, Vol. 191, 106709, 01.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months
AU - Steinbeis, Fridolin
AU - Thibeault, Charlotte
AU - Doellinger, Felix
AU - Ring, Raphaela Maria
AU - Mittermaier, Mirja
AU - Ruwwe-Glösenkamp, Christoph
AU - Alius, Florian
AU - Knape, Philipp
AU - Meyer, Hans-Jakob
AU - Lippert, Lena Johanna
AU - Helbig, Elisa Theresa
AU - Grund, Daniel
AU - Temmesfeld-Wollbrück, Bettina
AU - Suttorp, Norbert
AU - Sander, Leif Erik
AU - Kurth, Florian
AU - Penzkofer, Tobias
AU - Witzenrath, Martin
AU - Zoller, Thomas
N1 - Copyright © 2021 Elsevier Ltd. All rights reserved.
PY - 2022/1
Y1 - 2022/1
N2 - INTRODUCTION: Prospective and longitudinal data on pulmonary injury over one year after acute coronavirus disease 2019 (COVID-19) are sparse. We aim to determine reductions in pulmonary function and respiratory related quality of life up to 12 months after acute COVID-19.METHODS: Patients with acute COVID-19 were enrolled into an ongoing single-centre, prospective observational study and prospectively examined 6 weeks, 3, 6 and 12 months after onset of COVID-19 symptoms. Chest CT-scans, pulmonary function and symptoms assessed by St. Georges Respiratory Questionnaire were used to evaluate respiratory limitations. Patients were stratified according to severity of acute COVID-19.RESULTS: Median age of all patients was 57 years, 37.8% were female. Higher age, male sex and higher BMI were associated with acute-COVID-19 severity (p < 0.0001, 0.001 and 0.004 respectively). Also, pulmonary restriction and reduced carbon monoxide diffusion capacity was associated with disease severity. In patients with restriction and impaired diffusion capacity, FVC improved over 12 months from 61.32 to 71.82, TLC from 68.92 to 76.95, DLCO from 60.18 to 68.98 and KCO from 81.28 to 87.80 (percent predicted values; p = 0.002, 0.045, 0.0002 and 0.0005). The CT-score of lung involvement in the acute phase was associated with restriction and reduction in diffusion capacity in follow-up. Respiratory symptoms improved for patients in higher severity groups during follow-up, but not for patients with initially mild disease.CONCLUSION: Severity of respiratory failure during COVID-19 correlates with the degree of pulmonary function impairment and respiratory quality of life in the year after acute infection.
AB - INTRODUCTION: Prospective and longitudinal data on pulmonary injury over one year after acute coronavirus disease 2019 (COVID-19) are sparse. We aim to determine reductions in pulmonary function and respiratory related quality of life up to 12 months after acute COVID-19.METHODS: Patients with acute COVID-19 were enrolled into an ongoing single-centre, prospective observational study and prospectively examined 6 weeks, 3, 6 and 12 months after onset of COVID-19 symptoms. Chest CT-scans, pulmonary function and symptoms assessed by St. Georges Respiratory Questionnaire were used to evaluate respiratory limitations. Patients were stratified according to severity of acute COVID-19.RESULTS: Median age of all patients was 57 years, 37.8% were female. Higher age, male sex and higher BMI were associated with acute-COVID-19 severity (p < 0.0001, 0.001 and 0.004 respectively). Also, pulmonary restriction and reduced carbon monoxide diffusion capacity was associated with disease severity. In patients with restriction and impaired diffusion capacity, FVC improved over 12 months from 61.32 to 71.82, TLC from 68.92 to 76.95, DLCO from 60.18 to 68.98 and KCO from 81.28 to 87.80 (percent predicted values; p = 0.002, 0.045, 0.0002 and 0.0005). The CT-score of lung involvement in the acute phase was associated with restriction and reduction in diffusion capacity in follow-up. Respiratory symptoms improved for patients in higher severity groups during follow-up, but not for patients with initially mild disease.CONCLUSION: Severity of respiratory failure during COVID-19 correlates with the degree of pulmonary function impairment and respiratory quality of life in the year after acute infection.
KW - Adult
KW - Aged
KW - COVID-19/complications
KW - Extracorporeal Membrane Oxygenation
KW - Female
KW - Forced Expiratory Volume/physiology
KW - Hospitalization
KW - Humans
KW - Longitudinal Studies
KW - Lung/diagnostic imaging
KW - Male
KW - Middle Aged
KW - Oxygen Inhalation Therapy
KW - Pulmonary Diffusing Capacity/physiology
KW - Quality of Life
KW - Recovery of Function
KW - Respiration, Artificial
KW - Respiratory Function Tests
KW - Respiratory Insufficiency/diagnostic imaging
KW - SARS-CoV-2
KW - Severity of Illness Index
KW - Surveys and Questionnaires
KW - Tomography, X-Ray Computed
KW - Total Lung Capacity/physiology
KW - Vital Capacity/physiology
KW - Post-Acute COVID-19 Syndrome
U2 - 10.1016/j.rmed.2021.106709
DO - 10.1016/j.rmed.2021.106709
M3 - SCORING: Journal article
C2 - 34871947
VL - 191
JO - RESP MED
JF - RESP MED
SN - 0954-6111
M1 - 106709
ER -
