Severe Pain Due to Paraspinal Abscess Formation in Two Patients with Squamous-Cell Carcinoma of the Head and Neck after Multimodal Treatment Including Cetuximab
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Severe Pain Due to Paraspinal Abscess Formation in Two Patients with Squamous-Cell Carcinoma of the Head and Neck after Multimodal Treatment Including Cetuximab. / Gerlach, Christina; Pretzell, Ina; Lieberknecht, Elisabeth; Mattyasovszky, Stefan; Weber, Martin.
In: ONCOL RES TREAT, Vol. 41, No. 6, 2018, p. 395-398.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Severe Pain Due to Paraspinal Abscess Formation in Two Patients with Squamous-Cell Carcinoma of the Head and Neck after Multimodal Treatment Including Cetuximab
AU - Gerlach, Christina
AU - Pretzell, Ina
AU - Lieberknecht, Elisabeth
AU - Mattyasovszky, Stefan
AU - Weber, Martin
N1 - © 2018 S. Karger GmbH, Freiburg.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Patients with squamous-cell carcinoma of the head and neck (SCCHN) on palliative therapy usually have a bad prognosis and suffer from various symptoms. With increasing use of targeted agents in cancer patients at the end of life, the correct assignment of therapy-related symptoms becomes increasingly difficult as cancer-related symptoms usually increase as well.CASE REPORT: We report on 2 cases of patients with SCCHN who received multimodal treatment including palliative therapy with cetuximab. Both patients developed severe thoracic and cervicothoracic pain following treatment. In both cases, extensive paraspinal abscess formation proved to be the underlying cause. One patient was treated conservatively; the other one had to undergo surgical intervention.CONCLUSIONS: Awareness of multifaceted therapy-related complications is mandatory when patients receive multimodal treatment including targeted therapies. Unexplained pain syndromes in this context should raise suspicions concerning possible infectious complications and should lead to early use of magnetic resonance imaging.
AB - BACKGROUND: Patients with squamous-cell carcinoma of the head and neck (SCCHN) on palliative therapy usually have a bad prognosis and suffer from various symptoms. With increasing use of targeted agents in cancer patients at the end of life, the correct assignment of therapy-related symptoms becomes increasingly difficult as cancer-related symptoms usually increase as well.CASE REPORT: We report on 2 cases of patients with SCCHN who received multimodal treatment including palliative therapy with cetuximab. Both patients developed severe thoracic and cervicothoracic pain following treatment. In both cases, extensive paraspinal abscess formation proved to be the underlying cause. One patient was treated conservatively; the other one had to undergo surgical intervention.CONCLUSIONS: Awareness of multifaceted therapy-related complications is mandatory when patients receive multimodal treatment including targeted therapies. Unexplained pain syndromes in this context should raise suspicions concerning possible infectious complications and should lead to early use of magnetic resonance imaging.
KW - Abscess/complications
KW - Aged
KW - Antineoplastic Agents, Immunological/adverse effects
KW - Carcinoma, Squamous Cell/therapy
KW - Cetuximab/adverse effects
KW - Combined Modality Therapy
KW - Female
KW - Head and Neck Neoplasms/therapy
KW - Humans
KW - Male
KW - Middle Aged
KW - Pain/diagnosis
KW - Palliative Care/methods
KW - Severity of Illness Index
KW - Spinal Diseases/complications
U2 - 10.1159/000486758
DO - 10.1159/000486758
M3 - SCORING: Journal article
C2 - 29734190
VL - 41
SP - 395
EP - 398
JO - ONCOL RES TREAT
JF - ONCOL RES TREAT
SN - 2296-5270
IS - 6
ER -
