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Severe occupational asthma: Insights from a multicenter European cohort

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Severe occupational asthma: Insights from a multicenter European cohort. / Vandenplas, Olivier; Godet, Julien; Hurdubaea, Laura; Rifflart, Catherine; Suojalehto, Hille; Walusiak-Skorupa, Jolanta; Munoz, Xavier; Sastre, Joaquin; Klusackova, Pavlina; Moore, Vicky; Merget, Rolf; Talini, Donatella; Kirkeleit, Jorunn; Mason, Paola; Folletti, Ilenia; Cullinan, Paul; Moscato, Gianna; Quirce, Santiago; Hoyle, Jennifer; Sherson, David; Kauppi, Paula; Preisser, Alexandra; Meyer, Nicolas; de Blay, Frédéric; European network for the PHenotyping of OCcupational ASthma (E-PHOCAS).

In: J ALLER CL IMM-PRACT, Vol. 7, No. 7, 28.03.2019, p. 2309-2318.e4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vandenplas, O, Godet, J, Hurdubaea, L, Rifflart, C, Suojalehto, H, Walusiak-Skorupa, J, Munoz, X, Sastre, J, Klusackova, P, Moore, V, Merget, R, Talini, D, Kirkeleit, J, Mason, P, Folletti, I, Cullinan, P, Moscato, G, Quirce, S, Hoyle, J, Sherson, D, Kauppi, P, Preisser, A, Meyer, N, de Blay, F & European network for the PHenotyping of OCcupational ASthma (E-PHOCAS) 2019, 'Severe occupational asthma: Insights from a multicenter European cohort', J ALLER CL IMM-PRACT, vol. 7, no. 7, pp. 2309-2318.e4. https://doi.org/10.1016/j.jaip.2019.03.017

APA

Vandenplas, O., Godet, J., Hurdubaea, L., Rifflart, C., Suojalehto, H., Walusiak-Skorupa, J., Munoz, X., Sastre, J., Klusackova, P., Moore, V., Merget, R., Talini, D., Kirkeleit, J., Mason, P., Folletti, I., Cullinan, P., Moscato, G., Quirce, S., Hoyle, J., ... European network for the PHenotyping of OCcupational ASthma (E-PHOCAS) (2019). Severe occupational asthma: Insights from a multicenter European cohort. J ALLER CL IMM-PRACT, 7(7), 2309-2318.e4. https://doi.org/10.1016/j.jaip.2019.03.017

Vancouver

Vandenplas O, Godet J, Hurdubaea L, Rifflart C, Suojalehto H, Walusiak-Skorupa J et al. Severe occupational asthma: Insights from a multicenter European cohort. J ALLER CL IMM-PRACT. 2019 Mar 28;7(7):2309-2318.e4. https://doi.org/10.1016/j.jaip.2019.03.017

Bibtex

@article{d9823e272e53412daee692ab546a8ef5,
title = "Severe occupational asthma: Insights from a multicenter European cohort",
abstract = "BACKGROUND: Although sensitizer-induced occupational asthma (OA) accounts for an appreciable fraction of adult asthma, the severity of OA has received little attention.OBJECTIVE: The aim of this study was to characterize the burden and determinants of severe OA in a large multicenter cohort of subjects with OA.METHODS: This retrospective study included 997 subjects with OA ascertained by a positive specific inhalation challenge completed in 20 tertiary centers in 11 European countries during the period 2006 to 2015. Severe asthma was defined by a high level of treatment and any 1 of the following criteria: (1) daily need for a reliever medication, (2) 2 or more severe exacerbations in the previous year, or (3) airflow obstruction.RESULTS: Overall, 162 (16.2%; 95% CI, 14.0%-18.7%) subjects were classified as having severe OA. Multivariable logistic regression analysis revealed that severe OA was associated with persistent (vs reduced) exposure to the causal agent at work (odds ratio [OR], 2.78; 95% CI, 1.50-5.60); a longer duration of the disease (OR, 1.04; 95% CI, 1.00-1.07); a low level of education (OR, 2.69; 95% CI, 1.73-4.18); childhood asthma (OR, 2.92; 95% CI, 1.13-7.36); and sputum production (OR, 2.86; 95% CI, 1.87-4.38). In subjects removed from exposure, severe OA was associated only with sputum production (OR, 3.68; 95% CI, 1.87-7.40); a low education level (OR, 3.41; 95% CI, 1.72-6.80); and obesity (OR, 1.98; 95% CI, 0.97-3.97).CONCLUSIONS: This study indicates that a substantial proportion of subjects with OA experience severe asthma and identifies potentially modifiable risk factors for severe OA that should be targeted to reduce the adverse impacts of the disease.",
keywords = "Journal Article",
author = "Olivier Vandenplas and Julien Godet and Laura Hurdubaea and Catherine Rifflart and Hille Suojalehto and Jolanta Walusiak-Skorupa and Xavier Munoz and Joaquin Sastre and Pavlina Klusackova and Vicky Moore and Rolf Merget and Donatella Talini and Jorunn Kirkeleit and Paola Mason and Ilenia Folletti and Paul Cullinan and Gianna Moscato and Santiago Quirce and Jennifer Hoyle and David Sherson and Paula Kauppi and Alexandra Preisser and Nicolas Meyer and {de Blay}, Fr{\'e}d{\'e}ric and {European network for the PHenotyping of OCcupational ASthma (E-PHOCAS)}",
note = "Copyright {\textcopyright} 2019. Published by Elsevier Inc.",
year = "2019",
month = mar,
day = "28",
doi = "10.1016/j.jaip.2019.03.017",
language = "English",
volume = "7",
pages = "2309--2318.e4",
journal = "J ALLER CL IMM-PRACT",
issn = "2213-2198",
publisher = "Elsevier",
number = "7",

}

RIS

TY - JOUR

T1 - Severe occupational asthma: Insights from a multicenter European cohort

AU - Vandenplas, Olivier

AU - Godet, Julien

AU - Hurdubaea, Laura

AU - Rifflart, Catherine

AU - Suojalehto, Hille

AU - Walusiak-Skorupa, Jolanta

AU - Munoz, Xavier

AU - Sastre, Joaquin

AU - Klusackova, Pavlina

AU - Moore, Vicky

AU - Merget, Rolf

AU - Talini, Donatella

AU - Kirkeleit, Jorunn

AU - Mason, Paola

AU - Folletti, Ilenia

AU - Cullinan, Paul

AU - Moscato, Gianna

AU - Quirce, Santiago

AU - Hoyle, Jennifer

AU - Sherson, David

AU - Kauppi, Paula

AU - Preisser, Alexandra

AU - Meyer, Nicolas

AU - de Blay, Frédéric

AU - European network for the PHenotyping of OCcupational ASthma (E-PHOCAS)

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/3/28

Y1 - 2019/3/28

N2 - BACKGROUND: Although sensitizer-induced occupational asthma (OA) accounts for an appreciable fraction of adult asthma, the severity of OA has received little attention.OBJECTIVE: The aim of this study was to characterize the burden and determinants of severe OA in a large multicenter cohort of subjects with OA.METHODS: This retrospective study included 997 subjects with OA ascertained by a positive specific inhalation challenge completed in 20 tertiary centers in 11 European countries during the period 2006 to 2015. Severe asthma was defined by a high level of treatment and any 1 of the following criteria: (1) daily need for a reliever medication, (2) 2 or more severe exacerbations in the previous year, or (3) airflow obstruction.RESULTS: Overall, 162 (16.2%; 95% CI, 14.0%-18.7%) subjects were classified as having severe OA. Multivariable logistic regression analysis revealed that severe OA was associated with persistent (vs reduced) exposure to the causal agent at work (odds ratio [OR], 2.78; 95% CI, 1.50-5.60); a longer duration of the disease (OR, 1.04; 95% CI, 1.00-1.07); a low level of education (OR, 2.69; 95% CI, 1.73-4.18); childhood asthma (OR, 2.92; 95% CI, 1.13-7.36); and sputum production (OR, 2.86; 95% CI, 1.87-4.38). In subjects removed from exposure, severe OA was associated only with sputum production (OR, 3.68; 95% CI, 1.87-7.40); a low education level (OR, 3.41; 95% CI, 1.72-6.80); and obesity (OR, 1.98; 95% CI, 0.97-3.97).CONCLUSIONS: This study indicates that a substantial proportion of subjects with OA experience severe asthma and identifies potentially modifiable risk factors for severe OA that should be targeted to reduce the adverse impacts of the disease.

AB - BACKGROUND: Although sensitizer-induced occupational asthma (OA) accounts for an appreciable fraction of adult asthma, the severity of OA has received little attention.OBJECTIVE: The aim of this study was to characterize the burden and determinants of severe OA in a large multicenter cohort of subjects with OA.METHODS: This retrospective study included 997 subjects with OA ascertained by a positive specific inhalation challenge completed in 20 tertiary centers in 11 European countries during the period 2006 to 2015. Severe asthma was defined by a high level of treatment and any 1 of the following criteria: (1) daily need for a reliever medication, (2) 2 or more severe exacerbations in the previous year, or (3) airflow obstruction.RESULTS: Overall, 162 (16.2%; 95% CI, 14.0%-18.7%) subjects were classified as having severe OA. Multivariable logistic regression analysis revealed that severe OA was associated with persistent (vs reduced) exposure to the causal agent at work (odds ratio [OR], 2.78; 95% CI, 1.50-5.60); a longer duration of the disease (OR, 1.04; 95% CI, 1.00-1.07); a low level of education (OR, 2.69; 95% CI, 1.73-4.18); childhood asthma (OR, 2.92; 95% CI, 1.13-7.36); and sputum production (OR, 2.86; 95% CI, 1.87-4.38). In subjects removed from exposure, severe OA was associated only with sputum production (OR, 3.68; 95% CI, 1.87-7.40); a low education level (OR, 3.41; 95% CI, 1.72-6.80); and obesity (OR, 1.98; 95% CI, 0.97-3.97).CONCLUSIONS: This study indicates that a substantial proportion of subjects with OA experience severe asthma and identifies potentially modifiable risk factors for severe OA that should be targeted to reduce the adverse impacts of the disease.

KW - Journal Article

U2 - 10.1016/j.jaip.2019.03.017

DO - 10.1016/j.jaip.2019.03.017

M3 - SCORING: Journal article

C2 - 30914232

VL - 7

SP - 2309-2318.e4

JO - J ALLER CL IMM-PRACT

JF - J ALLER CL IMM-PRACT

SN - 2213-2198

IS - 7

ER -