Severe aortic arch calcification depicted on chest radiography strongly suggests coronary artery calcification

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Severe aortic arch calcification depicted on chest radiography strongly suggests coronary artery calcification. / Bannas, Peter; Jung, Caroline; Blanke, Philipp; Treszl, András; Derlin, Thorsten; Adam, Gerhard; Bley, Thorsten A.

In: EUR RADIOL, Vol. 23, No. 10, 01.10.2013, p. 2652-7.

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@article{6338cd392054472889df109a66422f3c,
title = "Severe aortic arch calcification depicted on chest radiography strongly suggests coronary artery calcification",
abstract = "OBJECTIVE: To evaluate the association between aortic arch calcifications (AAC) on chest radiography and coronary artery calcium (CAC) score determined by CT.METHODS: A total of 128 patients (75 men; 69.3 ± 14.7 years) who underwent chest radiography and CAC scoring at CT were included in this retrospective analysis. The extent of AAC on chest radiography was evaluated independently by two blinded observers using a semi-quantitative four-point scale (0-3). Intra- and interobserver agreement was assessed by weighted ĸ statistics. Amount of AAC determined on radiography was correlated with CAC and ROC analyses performed to characterise the diagnostic performance of AAC grading.RESULTS: Excellent intraobserver (ĸ = 0.82) and good interobserver (ĸ = 0.75) agreement of AAC grading was noted. Moderate agreement (ĸ = 0.46, 95 % CI 0.36-0.56) with a linear trend (P < 0.0001) between AAC grades and CAC scores was found. Cut-off between AAC grades 0-2 and 3 had a sensitivity of 38.6 %, specificity of 96.4 %, PPV of 85.0 %, NPV of 75.0 % and accuracy of 76.6 % for the correct identification of CAC scores greater than 400.CONCLUSION: Semi-quantitative AAC grading on chest radiography is reliable and positively associated with CAC scoring. We propose to report the extent of AAC in comprehensive radiological reports as {"}not present{"}, {"}moderate{"} or {"}severe{"}, as severe AAC strongly suggests coronary artery calcification.KEY POINTS: • Semi-quantitative aortic arch calcification (AAC) grading on plain chest radiography appears reliable. • AAC grading is positively associated with CT coronary artery calcium scoring. • AAC grading has a high specificity for ruling out CAC scores greater than 400. • We propose the reporting of the extent of AAC grade in chest X-ray (CXR) reports.",
keywords = "Aged, Aorta, Thoracic, Aortic Diseases, Calcinosis, Comorbidity, Coronary Angiography, Coronary Artery Disease, Female, Germany, Humans, Male, Prevalence, Radiography, Thoracic, Reproducibility of Results, Risk Factors, Sensitivity and Specificity",
author = "Peter Bannas and Caroline Jung and Philipp Blanke and Andr{\'a}s Treszl and Thorsten Derlin and Gerhard Adam and Bley, {Thorsten A}",
year = "2013",
month = oct,
day = "1",
doi = "10.1007/s00330-013-2877-z",
language = "English",
volume = "23",
pages = "2652--7",
journal = "EUR RADIOL",
issn = "0938-7994",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Severe aortic arch calcification depicted on chest radiography strongly suggests coronary artery calcification

AU - Bannas, Peter

AU - Jung, Caroline

AU - Blanke, Philipp

AU - Treszl, András

AU - Derlin, Thorsten

AU - Adam, Gerhard

AU - Bley, Thorsten A

PY - 2013/10/1

Y1 - 2013/10/1

N2 - OBJECTIVE: To evaluate the association between aortic arch calcifications (AAC) on chest radiography and coronary artery calcium (CAC) score determined by CT.METHODS: A total of 128 patients (75 men; 69.3 ± 14.7 years) who underwent chest radiography and CAC scoring at CT were included in this retrospective analysis. The extent of AAC on chest radiography was evaluated independently by two blinded observers using a semi-quantitative four-point scale (0-3). Intra- and interobserver agreement was assessed by weighted ĸ statistics. Amount of AAC determined on radiography was correlated with CAC and ROC analyses performed to characterise the diagnostic performance of AAC grading.RESULTS: Excellent intraobserver (ĸ = 0.82) and good interobserver (ĸ = 0.75) agreement of AAC grading was noted. Moderate agreement (ĸ = 0.46, 95 % CI 0.36-0.56) with a linear trend (P < 0.0001) between AAC grades and CAC scores was found. Cut-off between AAC grades 0-2 and 3 had a sensitivity of 38.6 %, specificity of 96.4 %, PPV of 85.0 %, NPV of 75.0 % and accuracy of 76.6 % for the correct identification of CAC scores greater than 400.CONCLUSION: Semi-quantitative AAC grading on chest radiography is reliable and positively associated with CAC scoring. We propose to report the extent of AAC in comprehensive radiological reports as "not present", "moderate" or "severe", as severe AAC strongly suggests coronary artery calcification.KEY POINTS: • Semi-quantitative aortic arch calcification (AAC) grading on plain chest radiography appears reliable. • AAC grading is positively associated with CT coronary artery calcium scoring. • AAC grading has a high specificity for ruling out CAC scores greater than 400. • We propose the reporting of the extent of AAC grade in chest X-ray (CXR) reports.

AB - OBJECTIVE: To evaluate the association between aortic arch calcifications (AAC) on chest radiography and coronary artery calcium (CAC) score determined by CT.METHODS: A total of 128 patients (75 men; 69.3 ± 14.7 years) who underwent chest radiography and CAC scoring at CT were included in this retrospective analysis. The extent of AAC on chest radiography was evaluated independently by two blinded observers using a semi-quantitative four-point scale (0-3). Intra- and interobserver agreement was assessed by weighted ĸ statistics. Amount of AAC determined on radiography was correlated with CAC and ROC analyses performed to characterise the diagnostic performance of AAC grading.RESULTS: Excellent intraobserver (ĸ = 0.82) and good interobserver (ĸ = 0.75) agreement of AAC grading was noted. Moderate agreement (ĸ = 0.46, 95 % CI 0.36-0.56) with a linear trend (P < 0.0001) between AAC grades and CAC scores was found. Cut-off between AAC grades 0-2 and 3 had a sensitivity of 38.6 %, specificity of 96.4 %, PPV of 85.0 %, NPV of 75.0 % and accuracy of 76.6 % for the correct identification of CAC scores greater than 400.CONCLUSION: Semi-quantitative AAC grading on chest radiography is reliable and positively associated with CAC scoring. We propose to report the extent of AAC in comprehensive radiological reports as "not present", "moderate" or "severe", as severe AAC strongly suggests coronary artery calcification.KEY POINTS: • Semi-quantitative aortic arch calcification (AAC) grading on plain chest radiography appears reliable. • AAC grading is positively associated with CT coronary artery calcium scoring. • AAC grading has a high specificity for ruling out CAC scores greater than 400. • We propose the reporting of the extent of AAC grade in chest X-ray (CXR) reports.

KW - Aged

KW - Aorta, Thoracic

KW - Aortic Diseases

KW - Calcinosis

KW - Comorbidity

KW - Coronary Angiography

KW - Coronary Artery Disease

KW - Female

KW - Germany

KW - Humans

KW - Male

KW - Prevalence

KW - Radiography, Thoracic

KW - Reproducibility of Results

KW - Risk Factors

KW - Sensitivity and Specificity

U2 - 10.1007/s00330-013-2877-z

DO - 10.1007/s00330-013-2877-z

M3 - SCORING: Journal article

C2 - 23660774

VL - 23

SP - 2652

EP - 2657

JO - EUR RADIOL

JF - EUR RADIOL

SN - 0938-7994

IS - 10

ER -