Several lymphoma-specific genetic events in parallel can be found in mature B-cell neoplasms.
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Several lymphoma-specific genetic events in parallel can be found in mature B-cell neoplasms. / Bacher, Ulrike; Haferlach, Torsten; Alpermann, Tamara; Kern, Wolfgang; Schnittger, Susanne; Haferlach, Claudia.
In: GENE CHROMOSOME CANC, Vol. 50, No. 1, 1, 2011, p. 43-50.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Several lymphoma-specific genetic events in parallel can be found in mature B-cell neoplasms.
AU - Bacher, Ulrike
AU - Haferlach, Torsten
AU - Alpermann, Tamara
AU - Kern, Wolfgang
AU - Schnittger, Susanne
AU - Haferlach, Claudia
PY - 2011
Y1 - 2011
N2 - The mature B-cell neoplasms frequently result from translocations involving the IGH gene localized on 14q32. In rare instances, combinations of different IGH rearrangements were described, and even coincidence of three genetic lymphoma-specific events has been rarely reported. We here present eight patients with triple hit lymphoma, and two with four different lymphoma specific events detected by chromosome banding analysis and interphase FISH (seven males, three females, 47-82 years). All showed bone marrow involvement (Burkitt's lymphoma: n = 5, diffuse large B-cell lymphoma: n = 2; features intermediate between BL/DLBCL: n = 1; secondary aggressive B-cell lymphoma: n = 1; follicular lymphoma: n = 1). Eight patients had triple hit lymphoma combining IGH-BCL2/t(14;18)(q32;q21), MYC/8q24, and BCL6/3q27 rearrangements. Two showed an additional IGH-CCND1/t(11;14)(q13;q32) as fourth genetic event (according to research of the Mitelman database, the first reports on four genetic hits in lymphomas). All cases had complex aberrant karyotypes (median, 11 cytogenetic alterations per patient). Interphase FISH revealed a high rate of CDKN2A deletions (five of nine cases investigated; 56%), being homozygous in two of these cases. At the time of study, four of nine patients with follow-up data were alive (44%), one of these in remission. The two patients with four genetic hits died 6 and 9 days from diagnosis. Additional cases of lymphomas with three or four genetic hits should be collected to evaluate whether their clinical course differs from dual hit lymphomas.
AB - The mature B-cell neoplasms frequently result from translocations involving the IGH gene localized on 14q32. In rare instances, combinations of different IGH rearrangements were described, and even coincidence of three genetic lymphoma-specific events has been rarely reported. We here present eight patients with triple hit lymphoma, and two with four different lymphoma specific events detected by chromosome banding analysis and interphase FISH (seven males, three females, 47-82 years). All showed bone marrow involvement (Burkitt's lymphoma: n = 5, diffuse large B-cell lymphoma: n = 2; features intermediate between BL/DLBCL: n = 1; secondary aggressive B-cell lymphoma: n = 1; follicular lymphoma: n = 1). Eight patients had triple hit lymphoma combining IGH-BCL2/t(14;18)(q32;q21), MYC/8q24, and BCL6/3q27 rearrangements. Two showed an additional IGH-CCND1/t(11;14)(q13;q32) as fourth genetic event (according to research of the Mitelman database, the first reports on four genetic hits in lymphomas). All cases had complex aberrant karyotypes (median, 11 cytogenetic alterations per patient). Interphase FISH revealed a high rate of CDKN2A deletions (five of nine cases investigated; 56%), being homozygous in two of these cases. At the time of study, four of nine patients with follow-up data were alive (44%), one of these in remission. The two patients with four genetic hits died 6 and 9 days from diagnosis. Additional cases of lymphomas with three or four genetic hits should be collected to evaluate whether their clinical course differs from dual hit lymphomas.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Cohort Studies
KW - Gene Deletion
KW - Chromosomes, Human, Pair 18
KW - In Situ Hybridization, Fluorescence
KW - Translocation, Genetic
KW - Gene Rearrangement
KW - Databases, Genetic
KW - Chromosomes, Human, Pair 14
KW - Genes, Immunoglobulin Heavy Chain
KW - Lymphoma, B-Cell/genetics
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Cohort Studies
KW - Gene Deletion
KW - Chromosomes, Human, Pair 18
KW - In Situ Hybridization, Fluorescence
KW - Translocation, Genetic
KW - Gene Rearrangement
KW - Databases, Genetic
KW - Chromosomes, Human, Pair 14
KW - Genes, Immunoglobulin Heavy Chain
KW - Lymphoma, B-Cell/genetics
M3 - SCORING: Journal article
VL - 50
SP - 43
EP - 50
JO - GENE CHROMOSOME CANC
JF - GENE CHROMOSOME CANC
SN - 1045-2257
IS - 1
M1 - 1
ER -
