Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study
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Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study. / Lubos, Edith; Sinning, Christoph R; Schnabel, Renate B; Wild, Philipp S; Zeller, Tanja; Rupprecht, Hans J; Bickel, Christoph; Lackner, Karl J; Peetz, Dirk; Loscalzo, Joseph; Münzel, Thomas; Blankenberg, Stefan.
In: ATHEROSCLEROSIS, Vol. 209, No. 1, 03.2010, p. 271-7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study
AU - Lubos, Edith
AU - Sinning, Christoph R
AU - Schnabel, Renate B
AU - Wild, Philipp S
AU - Zeller, Tanja
AU - Rupprecht, Hans J
AU - Bickel, Christoph
AU - Lackner, Karl J
AU - Peetz, Dirk
AU - Loscalzo, Joseph
AU - Münzel, Thomas
AU - Blankenberg, Stefan
PY - 2010/3
Y1 - 2010/3
N2 - OBJECTIVE: Experimental data suggest a protective role of the essential trace element selenium against cardiovascular disease (CVD), whereas epidemiological data remains controversial. We aimed to investigate the impact of serum selenium concentration in patients presenting with stable angina pectoris (SAP) or acute coronary syndrome (ACS) on long term prognosis.METHODS: Baseline selenium concentration was measured in 1731 individuals (852 with SAP, and 879 with ACS). During a median follow-up of 6.1 years, 190 individuals died from cardiovascular causes.RESULTS: In those ACS patients who subsequently died of cardiac causes, selenium levels were lower compared to survivors (61.0microg/L versus 71.5microg/L; P<0.0001). In a fully adjusted model, patients in the highest tertile of selenium concentration had a hazard ratio of 0.38 (95% CI: 0.16-0.91; P=0.03) as compared with those in the lowest. No association between selenium levels and cardiovascular outcome was observed in SAP.CONCLUSIONS: Low selenium concentration was associated with future cardiovascular death in patients with ACS.
AB - OBJECTIVE: Experimental data suggest a protective role of the essential trace element selenium against cardiovascular disease (CVD), whereas epidemiological data remains controversial. We aimed to investigate the impact of serum selenium concentration in patients presenting with stable angina pectoris (SAP) or acute coronary syndrome (ACS) on long term prognosis.METHODS: Baseline selenium concentration was measured in 1731 individuals (852 with SAP, and 879 with ACS). During a median follow-up of 6.1 years, 190 individuals died from cardiovascular causes.RESULTS: In those ACS patients who subsequently died of cardiac causes, selenium levels were lower compared to survivors (61.0microg/L versus 71.5microg/L; P<0.0001). In a fully adjusted model, patients in the highest tertile of selenium concentration had a hazard ratio of 0.38 (95% CI: 0.16-0.91; P=0.03) as compared with those in the lowest. No association between selenium levels and cardiovascular outcome was observed in SAP.CONCLUSIONS: Low selenium concentration was associated with future cardiovascular death in patients with ACS.
KW - Acute Coronary Syndrome/blood
KW - Aged
KW - Angina Pectoris/blood
KW - Atherosclerosis/blood
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Prospective Studies
KW - Selenium/blood
KW - Survival Rate
U2 - 10.1016/j.atherosclerosis.2009.09.008
DO - 10.1016/j.atherosclerosis.2009.09.008
M3 - SCORING: Journal article
C2 - 19836749
VL - 209
SP - 271
EP - 277
JO - ATHEROSCLEROSIS
JF - ATHEROSCLEROSIS
SN - 0021-9150
IS - 1
ER -
