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Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes

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Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes. / Amrein, Melissa; Meier, Stephanie; Schäfer, Ibrahim; Schaedelin, Sabine; Willemse, Eline; Benkert, Pascal; Walter, Joan; Puelacher, Christian; Zimmermann, Tobias; Median, Daniela; Egli, Caroline; Leppert, David; Twerenbold, Raphael; Zellweger, Michael; Kuhle, Jens; Mueller, Christian.

In: BIOMARKERS, Vol. 28, No. 3, 05.2023, p. 341-351.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Amrein, M, Meier, S, Schäfer, I, Schaedelin, S, Willemse, E, Benkert, P, Walter, J, Puelacher, C, Zimmermann, T, Median, D, Egli, C, Leppert, D, Twerenbold, R, Zellweger, M, Kuhle, J & Mueller, C 2023, 'Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes', BIOMARKERS, vol. 28, no. 3, pp. 341-351. https://doi.org/10.1080/1354750X.2023.2172211

APA

Amrein, M., Meier, S., Schäfer, I., Schaedelin, S., Willemse, E., Benkert, P., Walter, J., Puelacher, C., Zimmermann, T., Median, D., Egli, C., Leppert, D., Twerenbold, R., Zellweger, M., Kuhle, J., & Mueller, C. (2023). Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes. BIOMARKERS, 28(3), 341-351. https://doi.org/10.1080/1354750X.2023.2172211

Vancouver

Amrein M, Meier S, Schäfer I, Schaedelin S, Willemse E, Benkert P et al. Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes. BIOMARKERS. 2023 May;28(3):341-351. https://doi.org/10.1080/1354750X.2023.2172211

Bibtex

@article{5571ddd43df14fbb900a5c6f7b189daa,
title = "Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes",
abstract = "Background: Functionally relevant coronary artery disease (fCAD), causing symptoms of myocardial ischemia, can currently only be reliably detected with advanced cardiac imaging. Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury known to be elevated by cardiovascular (CV) risk factors and cerebrovascular small-vessel diseases. Due to their pathophysiological similarities with fCAD and the link to CV risk factors, we hypothesised that sNfL may have diagnostic and prognostic value for fCAD and adverse cardiovascular outcomes.Methods: Of the large prospective Basel VIII study (NCT01838148), 4'016 consecutive patients undergoing cardiac work-up for suspected fCAD were included (median age 68 years, 32.5% women, 46.9% with history of CAD). The presence of fCAD was adjudicated using myocardial perfusion imaging single-photon emission tomography (MPI-SPECT) and coronary angiography. sNfL was measured using a high-sensitive single-molecule array assay. All-cause and cardiovascular death, myocardial infarction (MI), and stroke/transient ischaemic attack (TIA) during 5-year follow-up were the prognostic endpoints.Results: The diagnostic accuracy of sNfL for fCAD as quantified by the area under the curve (AUC) was low (0.58, 95%CI 0.56-0.60). sNfL was strongly associated with age, renal dysfunction, and body mass index and was a strong and independent predictor of all-cause death, cardiovascular death, and stroke/TIA but not MI. Time-dependent AUC for cardiovascular-death at 1-year was 0.85, 95%CI 0.80-0.89, and 0.81, 95%CI 0.77-0.86 at 2-years.Conclusion: While sNfL concentrations did not show a diagnostic role for fCAD, in contrast, sNfL was a strong and independent predictor of cardiovascular outcomes, including all-cause death, cardiovascular death and stroke/TIA.",
keywords = "Humans, Female, Aged, Male, Coronary Artery Disease, Ischemic Attack, Transient, Prospective Studies, Intermediate Filaments, Prognosis, Stroke/diagnosis, Myocardial Infarction",
author = "Melissa Amrein and Stephanie Meier and Ibrahim Sch{\"a}fer and Sabine Schaedelin and Eline Willemse and Pascal Benkert and Joan Walter and Christian Puelacher and Tobias Zimmermann and Daniela Median and Caroline Egli and David Leppert and Raphael Twerenbold and Michael Zellweger and Jens Kuhle and Christian Mueller",
year = "2023",
month = may,
doi = "10.1080/1354750X.2023.2172211",
language = "English",
volume = "28",
pages = "341--351",
journal = "BIOMARKERS",
issn = "1354-750X",
publisher = "informa healthcare",
number = "3",

}

RIS

TY - JOUR

T1 - Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes

AU - Amrein, Melissa

AU - Meier, Stephanie

AU - Schäfer, Ibrahim

AU - Schaedelin, Sabine

AU - Willemse, Eline

AU - Benkert, Pascal

AU - Walter, Joan

AU - Puelacher, Christian

AU - Zimmermann, Tobias

AU - Median, Daniela

AU - Egli, Caroline

AU - Leppert, David

AU - Twerenbold, Raphael

AU - Zellweger, Michael

AU - Kuhle, Jens

AU - Mueller, Christian

PY - 2023/5

Y1 - 2023/5

N2 - Background: Functionally relevant coronary artery disease (fCAD), causing symptoms of myocardial ischemia, can currently only be reliably detected with advanced cardiac imaging. Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury known to be elevated by cardiovascular (CV) risk factors and cerebrovascular small-vessel diseases. Due to their pathophysiological similarities with fCAD and the link to CV risk factors, we hypothesised that sNfL may have diagnostic and prognostic value for fCAD and adverse cardiovascular outcomes.Methods: Of the large prospective Basel VIII study (NCT01838148), 4'016 consecutive patients undergoing cardiac work-up for suspected fCAD were included (median age 68 years, 32.5% women, 46.9% with history of CAD). The presence of fCAD was adjudicated using myocardial perfusion imaging single-photon emission tomography (MPI-SPECT) and coronary angiography. sNfL was measured using a high-sensitive single-molecule array assay. All-cause and cardiovascular death, myocardial infarction (MI), and stroke/transient ischaemic attack (TIA) during 5-year follow-up were the prognostic endpoints.Results: The diagnostic accuracy of sNfL for fCAD as quantified by the area under the curve (AUC) was low (0.58, 95%CI 0.56-0.60). sNfL was strongly associated with age, renal dysfunction, and body mass index and was a strong and independent predictor of all-cause death, cardiovascular death, and stroke/TIA but not MI. Time-dependent AUC for cardiovascular-death at 1-year was 0.85, 95%CI 0.80-0.89, and 0.81, 95%CI 0.77-0.86 at 2-years.Conclusion: While sNfL concentrations did not show a diagnostic role for fCAD, in contrast, sNfL was a strong and independent predictor of cardiovascular outcomes, including all-cause death, cardiovascular death and stroke/TIA.

AB - Background: Functionally relevant coronary artery disease (fCAD), causing symptoms of myocardial ischemia, can currently only be reliably detected with advanced cardiac imaging. Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury known to be elevated by cardiovascular (CV) risk factors and cerebrovascular small-vessel diseases. Due to their pathophysiological similarities with fCAD and the link to CV risk factors, we hypothesised that sNfL may have diagnostic and prognostic value for fCAD and adverse cardiovascular outcomes.Methods: Of the large prospective Basel VIII study (NCT01838148), 4'016 consecutive patients undergoing cardiac work-up for suspected fCAD were included (median age 68 years, 32.5% women, 46.9% with history of CAD). The presence of fCAD was adjudicated using myocardial perfusion imaging single-photon emission tomography (MPI-SPECT) and coronary angiography. sNfL was measured using a high-sensitive single-molecule array assay. All-cause and cardiovascular death, myocardial infarction (MI), and stroke/transient ischaemic attack (TIA) during 5-year follow-up were the prognostic endpoints.Results: The diagnostic accuracy of sNfL for fCAD as quantified by the area under the curve (AUC) was low (0.58, 95%CI 0.56-0.60). sNfL was strongly associated with age, renal dysfunction, and body mass index and was a strong and independent predictor of all-cause death, cardiovascular death, and stroke/TIA but not MI. Time-dependent AUC for cardiovascular-death at 1-year was 0.85, 95%CI 0.80-0.89, and 0.81, 95%CI 0.77-0.86 at 2-years.Conclusion: While sNfL concentrations did not show a diagnostic role for fCAD, in contrast, sNfL was a strong and independent predictor of cardiovascular outcomes, including all-cause death, cardiovascular death and stroke/TIA.

KW - Humans

KW - Female

KW - Aged

KW - Male

KW - Coronary Artery Disease

KW - Ischemic Attack, Transient

KW - Prospective Studies

KW - Intermediate Filaments

KW - Prognosis

KW - Stroke/diagnosis

KW - Myocardial Infarction

U2 - 10.1080/1354750X.2023.2172211

DO - 10.1080/1354750X.2023.2172211

M3 - SCORING: Journal article

C2 - 36714921

VL - 28

SP - 341

EP - 351

JO - BIOMARKERS

JF - BIOMARKERS

SN - 1354-750X

IS - 3

ER -