Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection
Standard
Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection. / Beinhardt, Sandra; Aberle, Judith H; Strasser, Michael; Dulic-Lakovic, Emina; Maieron, Andreas; Kreil, Anna; Rutter, Karoline; Staettermayer, Albert F; Datz, Christian; Scherzer, Thomas M; Strassl, Robert; Bischof, Martin; Stauber, Rudolf; Bodlaj, Gerd; Laferl, Hermann; Holzmann, Heidemarie; Steindl-Munda, Petra; Ferenci, Peter; Hofer, Harald.
In: GASTROENTEROLOGY, Vol. 142, No. 1, 01.01.2012, p. 78-85.e2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection
AU - Beinhardt, Sandra
AU - Aberle, Judith H
AU - Strasser, Michael
AU - Dulic-Lakovic, Emina
AU - Maieron, Andreas
AU - Kreil, Anna
AU - Rutter, Karoline
AU - Staettermayer, Albert F
AU - Datz, Christian
AU - Scherzer, Thomas M
AU - Strassl, Robert
AU - Bischof, Martin
AU - Stauber, Rudolf
AU - Bodlaj, Gerd
AU - Laferl, Hermann
AU - Holzmann, Heidemarie
AU - Steindl-Munda, Petra
AU - Ferenci, Peter
AU - Hofer, Harald
N1 - Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - BACKGROUND & AIMS: Single nucleotide polymorphisms (SNPs) in IL28B and serum levels of interferon γ inducible protein 10 (IP-10) predict outcomes of antiviral therapy in patients with chronic hepatitis C. We associated IL28B SNPs rs12979860 and rs8099917, along with serum levels of IP-10, with outcomes of patients with acute hepatitis C (AHC).METHODS: We studied 120 patients with AHC (64 male; 37 ± 16 years old) and 96 healthy individuals (controls). The IL28B SNPs rs12979860 and rs8099917 were detected using real-time polymerase chain reaction; serum concentrations of IP-10 were measured by enzyme-linked immunosorbent assays of 62 patients with AHC.RESULTS: Hepatitis C virus was cleared spontaneously from 59 patients (49.2%). The IL28B rs12979860 C/C genotype was more frequent among patients with AHC than controls (62.5% vs 39.6%; P < .001) and among patients with spontaneous clearance than those without (74.6% vs 51.7%; P = .02) (positive predictive value, 60.3%). Patients with IL28B rs12979860 C/C more frequently developed jaundice (53.2% vs 27.6%; P = .022) than carriers of the T allele. The median level of IP-10 was lower among patients with AHC and spontaneous clearance (764 [113-2470] pg/mL) than those without spontaneous clearance (1481 [141-4412] pg/mL; P = .006). Based on receiver operating characteristic analysis, 540 pg/mL IP-10 was set as the cutoff for patients most likely to have spontaneous clearance (positive predictive value, 71.4%; negative predictive value, 65.9%). Including data on IP-10 levels increased the ability of the IL28B rs12979860 C/C to identify patients most likely to have spontaneous clearance (83% of those who had an IP-10 level <540 pg/mL and 32% who had an IP-10 level >540 pg/mL) (P < .01).CONCLUSIONS: The combination of serum level of IP-10 and SNPs in IL28B can identify patients with AHC who are most likely to undergo spontaneous clearance and those in need of early antiviral therapy.
AB - BACKGROUND & AIMS: Single nucleotide polymorphisms (SNPs) in IL28B and serum levels of interferon γ inducible protein 10 (IP-10) predict outcomes of antiviral therapy in patients with chronic hepatitis C. We associated IL28B SNPs rs12979860 and rs8099917, along with serum levels of IP-10, with outcomes of patients with acute hepatitis C (AHC).METHODS: We studied 120 patients with AHC (64 male; 37 ± 16 years old) and 96 healthy individuals (controls). The IL28B SNPs rs12979860 and rs8099917 were detected using real-time polymerase chain reaction; serum concentrations of IP-10 were measured by enzyme-linked immunosorbent assays of 62 patients with AHC.RESULTS: Hepatitis C virus was cleared spontaneously from 59 patients (49.2%). The IL28B rs12979860 C/C genotype was more frequent among patients with AHC than controls (62.5% vs 39.6%; P < .001) and among patients with spontaneous clearance than those without (74.6% vs 51.7%; P = .02) (positive predictive value, 60.3%). Patients with IL28B rs12979860 C/C more frequently developed jaundice (53.2% vs 27.6%; P = .022) than carriers of the T allele. The median level of IP-10 was lower among patients with AHC and spontaneous clearance (764 [113-2470] pg/mL) than those without spontaneous clearance (1481 [141-4412] pg/mL; P = .006). Based on receiver operating characteristic analysis, 540 pg/mL IP-10 was set as the cutoff for patients most likely to have spontaneous clearance (positive predictive value, 71.4%; negative predictive value, 65.9%). Including data on IP-10 levels increased the ability of the IL28B rs12979860 C/C to identify patients most likely to have spontaneous clearance (83% of those who had an IP-10 level <540 pg/mL and 32% who had an IP-10 level >540 pg/mL) (P < .01).CONCLUSIONS: The combination of serum level of IP-10 and SNPs in IL28B can identify patients with AHC who are most likely to undergo spontaneous clearance and those in need of early antiviral therapy.
KW - Acute Disease
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Austria
KW - Biological Markers
KW - Case-Control Studies
KW - Chemokine CXCL10
KW - Enzyme-Linked Immunosorbent Assay
KW - Female
KW - Gene Frequency
KW - Genotype
KW - Hepacivirus
KW - Hepatitis C
KW - Humans
KW - Interleukins
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Phenotype
KW - Polymorphism, Single Nucleotide
KW - Predictive Value of Tests
KW - Prognosis
KW - RNA, Viral
KW - ROC Curve
KW - Real-Time Polymerase Chain Reaction
KW - Remission, Spontaneous
KW - Viral Load
KW - Young Adult
U2 - 10.1053/j.gastro.2011.09.039
DO - 10.1053/j.gastro.2011.09.039
M3 - SCORING: Journal article
C2 - 22192885
VL - 142
SP - 78-85.e2
JO - GASTROENTEROLOGY
JF - GASTROENTEROLOGY
SN - 0016-5085
IS - 1
ER -