Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function
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Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. / Wersching, H; Duning, T; Lohmann, H; Mohammadi, S; Stehling, C; Fobker, M; Conty, M; Minnerup, J; Ringelstein, E B; Berger, K; Deppe, M; Knecht, S.
In: NEUROLOGY, Vol. 74, No. 13, 30.03.2010, p. 1022-9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function
AU - Wersching, H
AU - Duning, T
AU - Lohmann, H
AU - Mohammadi, S
AU - Stehling, C
AU - Fobker, M
AU - Conty, M
AU - Minnerup, J
AU - Ringelstein, E B
AU - Berger, K
AU - Deppe, M
AU - Knecht, S
PY - 2010/3/30
Y1 - 2010/3/30
N2 - OBJECTIVE: C-reactive protein is a marker of inflammation and vascular disease. It also seems to be associated with an increased risk of dementia. To better understand potential underlying mechanisms, we assessed microstructural brain integrity and cognitive performance relative to serum levels of high-sensitivity C-reactive protein (hs-CRP).METHODS: We cross-sectionally examined 447 community-dwelling and stroke-free individuals from the Systematic Evaluation and Alteration of Risk Factors for Cognitive Health (SEARCH) Health Study (mean age 63 years, 248 female). High-field MRI was performed in 321 of these subjects. Imaging measures included fluid-attenuated inversion recovery sequences for assessment of white matter hyperintensities, automated quantification of brain parenchyma volumes, and diffusion tensor imaging for calculation of global and regional white matter integrity, quantified by fractional anisotropy (FA). Psychometric analyses covered verbal memory, word fluency, and executive functions.RESULTS: Higher levels of hs-CRP were associated with worse performance in executive function after adjustment for age, gender, education, and cardiovascular risk factors in multiple regression analysis (beta = -0.095, p = 0.02). Moreover, higher hs-CRP was related to reduced global fractional anisotropy (beta = -0.237, p < 0.001), as well as regional FA scores of the frontal lobes (beta = -0.246, p < 0.001), the corona radiata (beta = -0.222, p < 0.001), and the corpus callosum (beta = -0.141, p = 0.016), in particular the genu (beta = -0.174, p = 0.004). We did not observe a significant association of hs-CRP with measures of white matter hyperintensities or brain atrophy.CONCLUSION: These data suggest that low-grade inflammation as assessed by high-sensitivity C-reactive protein is associated with cerebral microstructural disintegration that predominantly affects frontal pathways and corresponding executive function.
AB - OBJECTIVE: C-reactive protein is a marker of inflammation and vascular disease. It also seems to be associated with an increased risk of dementia. To better understand potential underlying mechanisms, we assessed microstructural brain integrity and cognitive performance relative to serum levels of high-sensitivity C-reactive protein (hs-CRP).METHODS: We cross-sectionally examined 447 community-dwelling and stroke-free individuals from the Systematic Evaluation and Alteration of Risk Factors for Cognitive Health (SEARCH) Health Study (mean age 63 years, 248 female). High-field MRI was performed in 321 of these subjects. Imaging measures included fluid-attenuated inversion recovery sequences for assessment of white matter hyperintensities, automated quantification of brain parenchyma volumes, and diffusion tensor imaging for calculation of global and regional white matter integrity, quantified by fractional anisotropy (FA). Psychometric analyses covered verbal memory, word fluency, and executive functions.RESULTS: Higher levels of hs-CRP were associated with worse performance in executive function after adjustment for age, gender, education, and cardiovascular risk factors in multiple regression analysis (beta = -0.095, p = 0.02). Moreover, higher hs-CRP was related to reduced global fractional anisotropy (beta = -0.237, p < 0.001), as well as regional FA scores of the frontal lobes (beta = -0.246, p < 0.001), the corona radiata (beta = -0.222, p < 0.001), and the corpus callosum (beta = -0.141, p = 0.016), in particular the genu (beta = -0.174, p = 0.004). We did not observe a significant association of hs-CRP with measures of white matter hyperintensities or brain atrophy.CONCLUSION: These data suggest that low-grade inflammation as assessed by high-sensitivity C-reactive protein is associated with cerebral microstructural disintegration that predominantly affects frontal pathways and corresponding executive function.
KW - Aging
KW - Anisotropy
KW - Brain
KW - C-Reactive Protein
KW - Cerebrovascular Disorders
KW - Cognition
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Diffusion Tensor Imaging
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Nerve Fibers, Myelinated
KW - Neural Pathways
KW - Neuropsychological Tests
KW - Psychometrics
KW - Regression Analysis
U2 - 10.1212/WNL.0b013e3181d7b45b
DO - 10.1212/WNL.0b013e3181d7b45b
M3 - SCORING: Journal article
C2 - 20350977
VL - 74
SP - 1022
EP - 1029
JO - NEUROLOGY
JF - NEUROLOGY
SN - 0028-3878
IS - 13
ER -
