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Sequential vs myeloablative vs reduced intensity conditioning for patients with myelodysplastic syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: a retrospective study by the chronic malignancies working party of the EBMT

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Sequential vs myeloablative vs reduced intensity conditioning for patients with myelodysplastic syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: a retrospective study by the chronic malignancies working party of the EBMT. / Potter, V; Gras, L; Koster, L; Kroger, N; Sockel, K; Ganser, A; Finke, J; Labussiere-Wallet, H; Peffault de Latour, R; Koc, Y; Salmenniemi, U; Smidstrup Friis, L; Jindra, P; Schroeder, T; Tischer, J; Arat, M; Pascual Cascon, M; de Wreede, L C; Hayden, P; Raj, K; Drozd-Sokolowska, J; Scheid, C; McLornan, D P; Robin, M; Yakoub-Agha, I.

In: BONE MARROW TRANSPL, Vol. 59, No. 2, 02.2024, p. 224-231.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Potter, V, Gras, L, Koster, L, Kroger, N, Sockel, K, Ganser, A, Finke, J, Labussiere-Wallet, H, Peffault de Latour, R, Koc, Y, Salmenniemi, U, Smidstrup Friis, L, Jindra, P, Schroeder, T, Tischer, J, Arat, M, Pascual Cascon, M, de Wreede, LC, Hayden, P, Raj, K, Drozd-Sokolowska, J, Scheid, C, McLornan, DP, Robin, M & Yakoub-Agha, I 2024, 'Sequential vs myeloablative vs reduced intensity conditioning for patients with myelodysplastic syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: a retrospective study by the chronic malignancies working party of the EBMT', BONE MARROW TRANSPL, vol. 59, no. 2, pp. 224-231. https://doi.org/10.1038/s41409-023-02111-3

APA

Potter, V., Gras, L., Koster, L., Kroger, N., Sockel, K., Ganser, A., Finke, J., Labussiere-Wallet, H., Peffault de Latour, R., Koc, Y., Salmenniemi, U., Smidstrup Friis, L., Jindra, P., Schroeder, T., Tischer, J., Arat, M., Pascual Cascon, M., de Wreede, L. C., Hayden, P., ... Yakoub-Agha, I. (2024). Sequential vs myeloablative vs reduced intensity conditioning for patients with myelodysplastic syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: a retrospective study by the chronic malignancies working party of the EBMT. BONE MARROW TRANSPL, 59(2), 224-231. https://doi.org/10.1038/s41409-023-02111-3

Vancouver

Potter V, Gras L, Koster L, Kroger N, Sockel K, Ganser A et al. Sequential vs myeloablative vs reduced intensity conditioning for patients with myelodysplastic syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: a retrospective study by the chronic malignancies working party of the EBMT. BONE MARROW TRANSPL. 2024 Feb;59(2):224-231. https://doi.org/10.1038/s41409-023-02111-3

Bibtex

@article{17091c8d25f64fa7b786f491d421eae2,
title = "Sequential vs myeloablative vs reduced intensity conditioning for patients with myelodysplastic syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: a retrospective study by the chronic malignancies working party of the EBMT",
abstract = "The optimal conditioning for patients with higher risk MDS receiving potentially curative allogeneic haematopoietic stem cell transplant(allo-HCT) remains to be defined. This is particularly the case for patients with excess of blasts at time of allo-HCT. Sequential (Seq) conditioning, whereby chemotherapy is followed rapidly by transplant conditioning, offers an opportunity to decrease disease burden, potentially improving outcomes allo-HCT outcomes. Herein we present the only analysis comparing Seq to myeloablative (MAC) and reduced intensity conditioning (RIC) specifically focussed on MDS patients with excess of blasts at allo-HCT. 303 patients were identified in the EBMT registry, receiving RIC (n = 158), Seq (n = 105), and MAC (n = 40). Median follow-up was 67.2 months and median age at allo-HCT was 59.5 years (IQR 53.5-65.6). For the entire cohort, 3 y overall survival (OS) was 50% (95% CI 45-56%) and relapse free survival (RFS) 45% (95% CI 40-51%). No significant differences in OS (log-rank p = 0.13) and RFS (log-rank p = 0.18) were observed between conditioning protocols. On multivariable analysis, lower performance status, worse IPSS-R cytogenetics, sibling donor (compared to 8/8 MUD) and ≥20% blasts at allo-HCT were associated with worse outcomes. In conclusion, the Seq protocol did little to influence the outcome in this high-risk group of patients, with outcomes mostly determined by baseline disease risk and patient characteristics such as performance status.",
author = "V Potter and L Gras and L Koster and N Kroger and K Sockel and A Ganser and J Finke and H Labussiere-Wallet and {Peffault de Latour}, R and Y Koc and U Salmenniemi and {Smidstrup Friis}, L and P Jindra and T Schroeder and J Tischer and M Arat and {Pascual Cascon}, M and {de Wreede}, {L C} and P Hayden and K Raj and J Drozd-Sokolowska and C Scheid and McLornan, {D P} and M Robin and I Yakoub-Agha",
note = "{\textcopyright} 2023. The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2024",
month = feb,
doi = "10.1038/s41409-023-02111-3",
language = "English",
volume = "59",
pages = "224--231",
journal = "BONE MARROW TRANSPL",
issn = "0268-3369",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Sequential vs myeloablative vs reduced intensity conditioning for patients with myelodysplastic syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: a retrospective study by the chronic malignancies working party of the EBMT

AU - Potter, V

AU - Gras, L

AU - Koster, L

AU - Kroger, N

AU - Sockel, K

AU - Ganser, A

AU - Finke, J

AU - Labussiere-Wallet, H

AU - Peffault de Latour, R

AU - Koc, Y

AU - Salmenniemi, U

AU - Smidstrup Friis, L

AU - Jindra, P

AU - Schroeder, T

AU - Tischer, J

AU - Arat, M

AU - Pascual Cascon, M

AU - de Wreede, L C

AU - Hayden, P

AU - Raj, K

AU - Drozd-Sokolowska, J

AU - Scheid, C

AU - McLornan, D P

AU - Robin, M

AU - Yakoub-Agha, I

N1 - © 2023. The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2024/2

Y1 - 2024/2

N2 - The optimal conditioning for patients with higher risk MDS receiving potentially curative allogeneic haematopoietic stem cell transplant(allo-HCT) remains to be defined. This is particularly the case for patients with excess of blasts at time of allo-HCT. Sequential (Seq) conditioning, whereby chemotherapy is followed rapidly by transplant conditioning, offers an opportunity to decrease disease burden, potentially improving outcomes allo-HCT outcomes. Herein we present the only analysis comparing Seq to myeloablative (MAC) and reduced intensity conditioning (RIC) specifically focussed on MDS patients with excess of blasts at allo-HCT. 303 patients were identified in the EBMT registry, receiving RIC (n = 158), Seq (n = 105), and MAC (n = 40). Median follow-up was 67.2 months and median age at allo-HCT was 59.5 years (IQR 53.5-65.6). For the entire cohort, 3 y overall survival (OS) was 50% (95% CI 45-56%) and relapse free survival (RFS) 45% (95% CI 40-51%). No significant differences in OS (log-rank p = 0.13) and RFS (log-rank p = 0.18) were observed between conditioning protocols. On multivariable analysis, lower performance status, worse IPSS-R cytogenetics, sibling donor (compared to 8/8 MUD) and ≥20% blasts at allo-HCT were associated with worse outcomes. In conclusion, the Seq protocol did little to influence the outcome in this high-risk group of patients, with outcomes mostly determined by baseline disease risk and patient characteristics such as performance status.

AB - The optimal conditioning for patients with higher risk MDS receiving potentially curative allogeneic haematopoietic stem cell transplant(allo-HCT) remains to be defined. This is particularly the case for patients with excess of blasts at time of allo-HCT. Sequential (Seq) conditioning, whereby chemotherapy is followed rapidly by transplant conditioning, offers an opportunity to decrease disease burden, potentially improving outcomes allo-HCT outcomes. Herein we present the only analysis comparing Seq to myeloablative (MAC) and reduced intensity conditioning (RIC) specifically focussed on MDS patients with excess of blasts at allo-HCT. 303 patients were identified in the EBMT registry, receiving RIC (n = 158), Seq (n = 105), and MAC (n = 40). Median follow-up was 67.2 months and median age at allo-HCT was 59.5 years (IQR 53.5-65.6). For the entire cohort, 3 y overall survival (OS) was 50% (95% CI 45-56%) and relapse free survival (RFS) 45% (95% CI 40-51%). No significant differences in OS (log-rank p = 0.13) and RFS (log-rank p = 0.18) were observed between conditioning protocols. On multivariable analysis, lower performance status, worse IPSS-R cytogenetics, sibling donor (compared to 8/8 MUD) and ≥20% blasts at allo-HCT were associated with worse outcomes. In conclusion, the Seq protocol did little to influence the outcome in this high-risk group of patients, with outcomes mostly determined by baseline disease risk and patient characteristics such as performance status.

U2 - 10.1038/s41409-023-02111-3

DO - 10.1038/s41409-023-02111-3

M3 - SCORING: Journal article

C2 - 37993503

VL - 59

SP - 224

EP - 231

JO - BONE MARROW TRANSPL

JF - BONE MARROW TRANSPL

SN - 0268-3369

IS - 2

ER -