Sequential Loss of Mandibular Permanent Incisors in Noonan Syndrome
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Sequential Loss of Mandibular Permanent Incisors in Noonan Syndrome. / Friedrich, Reinhard E; Scheuer, Hanna A.
In: IN VIVO, Vol. 36, No. 2, 05.03.2022, p. 1021-1029.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Sequential Loss of Mandibular Permanent Incisors in Noonan Syndrome
AU - Friedrich, Reinhard E
AU - Scheuer, Hanna A
N1 - Copyright © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2022/3/5
Y1 - 2022/3/5
N2 - BACKGROUND: Noonan syndrome (NS) is a multigenic disorder with a highly variable phenotype. Cardiac disorders and a predisposition to neoplasm often require early medical attention. Central giant central lesions (CGCLs) of the jaws are part of the phenotype.CASE REPORT: In a patient with genetically confirmed NS and multiple teeth loss presumably caused by CGCL, careful review of the medical history and radiographic findings made it probable that the cause of tooth loss was cervical root resorption (CRR) of the teeth following long-term orthodontic therapy.CONCLUSION: CRR is a rare dental disease of unknown origin. However, association with prior orthodontic therapy is well documented. In NS, mandibular lesions can occur which, at first glance, might lead the examiner to assume that it is a CGCL, but on closer analysis, obviously are of non-tumorous origin and should be assessed as coincidental. The report adds relevant information to orthodontic treatment of NS patients.
AB - BACKGROUND: Noonan syndrome (NS) is a multigenic disorder with a highly variable phenotype. Cardiac disorders and a predisposition to neoplasm often require early medical attention. Central giant central lesions (CGCLs) of the jaws are part of the phenotype.CASE REPORT: In a patient with genetically confirmed NS and multiple teeth loss presumably caused by CGCL, careful review of the medical history and radiographic findings made it probable that the cause of tooth loss was cervical root resorption (CRR) of the teeth following long-term orthodontic therapy.CONCLUSION: CRR is a rare dental disease of unknown origin. However, association with prior orthodontic therapy is well documented. In NS, mandibular lesions can occur which, at first glance, might lead the examiner to assume that it is a CGCL, but on closer analysis, obviously are of non-tumorous origin and should be assessed as coincidental. The report adds relevant information to orthodontic treatment of NS patients.
U2 - 10.21873/invivo.12797
DO - 10.21873/invivo.12797
M3 - SCORING: Journal article
C2 - 35241566
VL - 36
SP - 1021
EP - 1029
JO - IN VIVO
JF - IN VIVO
SN - 0258-851X
IS - 2
ER -