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Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques?

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Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques? / Jarczak, Dominik; Kluge, Stefan; Nierhaus, Axel.

In: INT J MOL SCI, Vol. 25, No. 6, 3120, 08.03.2024.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Jarczak, D, Kluge, S & Nierhaus, A 2024, 'Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques?', INT J MOL SCI, vol. 25, no. 6, 3120. https://doi.org/10.3390/ijms25063120

APA

Jarczak, D., Kluge, S., & Nierhaus, A. (2024). Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques? INT J MOL SCI, 25(6), [3120]. https://doi.org/10.3390/ijms25063120

Vancouver

Jarczak D, Kluge S, Nierhaus A. Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques? INT J MOL SCI. 2024 Mar 8;25(6). 3120. https://doi.org/10.3390/ijms25063120

Bibtex

@article{0afd6fe1b85d45bda2f36176373767db,
title = "Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques?",
abstract = "This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis characterized by an uncontrolled immune response leading to multiorgan dysfunction. We provide an overview of sepsis, focusing on the dynamics of immune response, the involvement of neutrophils, and the role of the endothelium in the disease's progression. It evaluates the effectiveness of various blood purification methods, including high-cut-off membranes, high-volume hemofiltration, adsorption techniques, and albumin dialysis, in removing cytokines and endotoxin and improving hemodynamic stability. Despite some very promising results, we conclude that the current evidence does not strongly support these techniques in significantly improving survival rates in septic patients, clearly underlining the need for further research.",
keywords = "Humans, Renal Dialysis, Hemofiltration/methods, Sepsis/therapy, Cytokines, Adsorption, Shock, Septic",
author = "Dominik Jarczak and Stefan Kluge and Axel Nierhaus",
year = "2024",
month = mar,
day = "8",
doi = "10.3390/ijms25063120",
language = "English",
volume = "25",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",

}

RIS

TY - JOUR

T1 - Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques?

AU - Jarczak, Dominik

AU - Kluge, Stefan

AU - Nierhaus, Axel

PY - 2024/3/8

Y1 - 2024/3/8

N2 - This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis characterized by an uncontrolled immune response leading to multiorgan dysfunction. We provide an overview of sepsis, focusing on the dynamics of immune response, the involvement of neutrophils, and the role of the endothelium in the disease's progression. It evaluates the effectiveness of various blood purification methods, including high-cut-off membranes, high-volume hemofiltration, adsorption techniques, and albumin dialysis, in removing cytokines and endotoxin and improving hemodynamic stability. Despite some very promising results, we conclude that the current evidence does not strongly support these techniques in significantly improving survival rates in septic patients, clearly underlining the need for further research.

AB - This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis characterized by an uncontrolled immune response leading to multiorgan dysfunction. We provide an overview of sepsis, focusing on the dynamics of immune response, the involvement of neutrophils, and the role of the endothelium in the disease's progression. It evaluates the effectiveness of various blood purification methods, including high-cut-off membranes, high-volume hemofiltration, adsorption techniques, and albumin dialysis, in removing cytokines and endotoxin and improving hemodynamic stability. Despite some very promising results, we conclude that the current evidence does not strongly support these techniques in significantly improving survival rates in septic patients, clearly underlining the need for further research.

KW - Humans

KW - Renal Dialysis

KW - Hemofiltration/methods

KW - Sepsis/therapy

KW - Cytokines

KW - Adsorption

KW - Shock, Septic

U2 - 10.3390/ijms25063120

DO - 10.3390/ijms25063120

M3 - SCORING: Review article

C2 - 38542094

VL - 25

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 6

M1 - 3120

ER -