Separating brain processing of pain from that of stimulus intensity.
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Separating brain processing of pain from that of stimulus intensity. / Oertel, Bruno G; Preibisch, Christine; Martin, Till; Walter, Carmen; Gamer, Matthias; Deichmann, Ralf; Lötsch, Jörn.
In: HUM BRAIN MAPP, Vol. 33, No. 4, 4, 2012, p. 883-894.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Separating brain processing of pain from that of stimulus intensity.
AU - Oertel, Bruno G
AU - Preibisch, Christine
AU - Martin, Till
AU - Walter, Carmen
AU - Gamer, Matthias
AU - Deichmann, Ralf
AU - Lötsch, Jörn
PY - 2012
Y1 - 2012
N2 - Regions of the brain network activated by painful stimuli are also activated by nonpainful and even nonsomatosensory stimuli. We therefore analyzed where the qualitative change from nonpainful to painful perception at the pain thresholds is coded. Noxious stimuli of gaseous carbon dioxide (n = 50) were applied to the nasal mucosa of 24 healthy volunteers at various concentrations from 10% below to 10% above the individual pain threshold. Functional magnetic resonance images showed that these trigeminal stimuli activated brain regions regarded as the "pain matrix." However, most of these activations, including the posterior insula, the primary and secondary somatosensory cortex, the amygdala, and the middle cingulate cortex, were associated with quantitative changes in stimulus intensity and did not exclusively reflect the qualitative change from nonpainful to pain. After subtracting brain activations associated with quantitative changes in the stimuli, the qualitative change, reflecting pain-exclusive activations, could be localized mainly in the posterior insular cortex. This shows that cerebral processing of noxious stimuli focuses predominately on the quantitative properties of stimulus intensity in both their sensory and affective dimensions, whereas the integration of this information into the perception of pain is restricted to a small part of the pain matrix.
AB - Regions of the brain network activated by painful stimuli are also activated by nonpainful and even nonsomatosensory stimuli. We therefore analyzed where the qualitative change from nonpainful to painful perception at the pain thresholds is coded. Noxious stimuli of gaseous carbon dioxide (n = 50) were applied to the nasal mucosa of 24 healthy volunteers at various concentrations from 10% below to 10% above the individual pain threshold. Functional magnetic resonance images showed that these trigeminal stimuli activated brain regions regarded as the "pain matrix." However, most of these activations, including the posterior insula, the primary and secondary somatosensory cortex, the amygdala, and the middle cingulate cortex, were associated with quantitative changes in stimulus intensity and did not exclusively reflect the qualitative change from nonpainful to pain. After subtracting brain activations associated with quantitative changes in the stimuli, the qualitative change, reflecting pain-exclusive activations, could be localized mainly in the posterior insular cortex. This shows that cerebral processing of noxious stimuli focuses predominately on the quantitative properties of stimulus intensity in both their sensory and affective dimensions, whereas the integration of this information into the perception of pain is restricted to a small part of the pain matrix.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Magnetic Resonance Imaging
KW - Image Interpretation, Computer-Assisted
KW - Brain Mapping
KW - Brain/physiology
KW - Physical Stimulation
KW - Pain Perception/physiology
KW - Pain/physiopathology/psychology
KW - Pain Threshold/physiology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Magnetic Resonance Imaging
KW - Image Interpretation, Computer-Assisted
KW - Brain Mapping
KW - Brain/physiology
KW - Physical Stimulation
KW - Pain Perception/physiology
KW - Pain/physiopathology/psychology
KW - Pain Threshold/physiology
M3 - SCORING: Journal article
VL - 33
SP - 883
EP - 894
JO - HUM BRAIN MAPP
JF - HUM BRAIN MAPP
SN - 1065-9471
IS - 4
M1 - 4
ER -