Sensory input drives multiple intracellular information streams in somatosensory cortex
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Sensory input drives multiple intracellular information streams in somatosensory cortex. / Alenda, Andrea; Molano-Mazón, Manuel; Panzeri, Stefano; Maravall, Miguel.
In: J NEUROSCI, Vol. 30, No. 32, 11.08.2010, p. 10872-84.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Sensory input drives multiple intracellular information streams in somatosensory cortex
AU - Alenda, Andrea
AU - Molano-Mazón, Manuel
AU - Panzeri, Stefano
AU - Maravall, Miguel
PY - 2010/8/11
Y1 - 2010/8/11
N2 - Stable perception arises from the interaction between sensory inputs and internal activity fluctuations in cortex. Here we analyzed how different types of activity contribute to cortical sensory processing at the cellular scale. We performed whole-cell recordings in the barrel cortex of anesthetized rats while applying ongoing whisker stimulation and measured the information conveyed about the time-varying stimulus by different types of input (membrane potential) and output (spiking) signals. We found that substantial, comparable amounts of incoming information are carried by two types of membrane potential signal: slow, large (up-down state) fluctuations, and faster (>20 Hz), smaller-amplitude synaptic activity. Both types of activity fluctuation are therefore significantly driven by the stimulus on an ongoing basis. Each stream conveys essentially independent information. Output (spiking) information is contained in spike timing not just relative to the stimulus but also relative to membrane potential fluctuations. Information transfer is favored in up states relative to down states. Thus, slow, ongoing activity fluctuations and finer-scale synaptic activity generate multiple channels for incoming and outgoing information within barrel cortex neurons during ongoing stimulation.
AB - Stable perception arises from the interaction between sensory inputs and internal activity fluctuations in cortex. Here we analyzed how different types of activity contribute to cortical sensory processing at the cellular scale. We performed whole-cell recordings in the barrel cortex of anesthetized rats while applying ongoing whisker stimulation and measured the information conveyed about the time-varying stimulus by different types of input (membrane potential) and output (spiking) signals. We found that substantial, comparable amounts of incoming information are carried by two types of membrane potential signal: slow, large (up-down state) fluctuations, and faster (>20 Hz), smaller-amplitude synaptic activity. Both types of activity fluctuation are therefore significantly driven by the stimulus on an ongoing basis. Each stream conveys essentially independent information. Output (spiking) information is contained in spike timing not just relative to the stimulus but also relative to membrane potential fluctuations. Information transfer is favored in up states relative to down states. Thus, slow, ongoing activity fluctuations and finer-scale synaptic activity generate multiple channels for incoming and outgoing information within barrel cortex neurons during ongoing stimulation.
KW - Action Potentials/physiology
KW - Afferent Pathways/physiology
KW - Age Factors
KW - Animals
KW - Animals, Newborn
KW - Extracellular Fluid/physiology
KW - Female
KW - Male
KW - Membrane Potentials/physiology
KW - Neurons/cytology
KW - Patch-Clamp Techniques
KW - Physical Stimulation/methods
KW - Psychophysics
KW - Rats
KW - Rats, Wistar
KW - Somatosensory Cortex/cytology
KW - Time Factors
KW - Vibrissae/innervation
U2 - 10.1523/JNEUROSCI.6174-09.2010
DO - 10.1523/JNEUROSCI.6174-09.2010
M3 - SCORING: Journal article
C2 - 20702716
VL - 30
SP - 10872
EP - 10884
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 32
ER -
