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Sensitivity of Hyperdense Basilar Artery Sign on Non-Enhanced Computed Tomography

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Sensitivity of Hyperdense Basilar Artery Sign on Non-Enhanced Computed Tomography. / Ernst, Marielle; Romero, Javier M; Buhk, Jan-Hendrik; Cheng, Bastian; Herrmann, Jochen; Fiehler, Jens; Groth, Michael.

In: PLOS ONE, Vol. 10, No. 10, 19.10.2015, p. Art. e0141096.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ernst, M, Romero, JM, Buhk, J-H, Cheng, B, Herrmann, J, Fiehler, J & Groth, M 2015, 'Sensitivity of Hyperdense Basilar Artery Sign on Non-Enhanced Computed Tomography', PLOS ONE, vol. 10, no. 10, pp. Art. e0141096. https://doi.org/10.1371/journal.pone.0141096

APA

Ernst, M., Romero, J. M., Buhk, J-H., Cheng, B., Herrmann, J., Fiehler, J., & Groth, M. (2015). Sensitivity of Hyperdense Basilar Artery Sign on Non-Enhanced Computed Tomography. PLOS ONE, 10(10), Art. e0141096. https://doi.org/10.1371/journal.pone.0141096

Vancouver

Ernst M, Romero JM, Buhk J-H, Cheng B, Herrmann J, Fiehler J et al. Sensitivity of Hyperdense Basilar Artery Sign on Non-Enhanced Computed Tomography. PLOS ONE. 2015 Oct 19;10(10):Art. e0141096. https://doi.org/10.1371/journal.pone.0141096

Bibtex

@article{eb4c2c34b30e4bd98d779f22e42299ad,
title = "Sensitivity of Hyperdense Basilar Artery Sign on Non-Enhanced Computed Tomography",
abstract = "PURPOSE: The hyperdense basilar artery sign (HBAS) is an indicator of vessel occlusion on non contrast-enhanced computer tomography (NECT) in acute stroke patients. Since basilar artery occlusion (BAO) is associated with a high mortality and morbidity, its early detection is of great clinical value. We sought to analyze the influence of density measurement as well as a normalized ratio of Hounsfield unit/hematocrit (HU/Hct) ratio on the detection of BAO on NECT in patients with suspected BAO.MATERIALS AND METHODS: 102 patients with clinically suspected BAO were examined with NECT followed immediately by Multidetector computed tomography Angiography. Two observers independently analyzed the images regarding the presence or absence of HBAS on NECT and performed HU measurements in the basilar artery. Receiver operating characteristic curve analysis was performed to determine the optimal density threshold for BAO using attenuation measurements or HU/Hct ratio.RESULTS: Sensitivity of visual detection of the HBAS on NECT was relatively low 81% (95%-CI, 54-95%) while specificity was high 91% (95%-CI, 82-96%). The highest sensitivity was achieved by the combination of visual assessment and additional quantitative attenuation measurements applying a cut-off value of 46.5 HU with 94% sensitivity and 81% specificity for BAO. A HU/Hct ratio >1.32 revealed sensitivity of 88% (95%-CI, 60-98%) and specificity of 84% (95%-CI, 74-90%).CONCLUSION: In patients with clinically suspected acute BAO the combination of visual assessment and additional attenuation measurement with a cut-off value of 46.5 HU is a reliable approach with high sensitivity in the detection of BAO on NECT.",
author = "Marielle Ernst and Romero, {Javier M} and Jan-Hendrik Buhk and Bastian Cheng and Jochen Herrmann and Jens Fiehler and Michael Groth",
year = "2015",
month = oct,
day = "19",
doi = "10.1371/journal.pone.0141096",
language = "English",
volume = "10",
pages = "Art. e0141096",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - Sensitivity of Hyperdense Basilar Artery Sign on Non-Enhanced Computed Tomography

AU - Ernst, Marielle

AU - Romero, Javier M

AU - Buhk, Jan-Hendrik

AU - Cheng, Bastian

AU - Herrmann, Jochen

AU - Fiehler, Jens

AU - Groth, Michael

PY - 2015/10/19

Y1 - 2015/10/19

N2 - PURPOSE: The hyperdense basilar artery sign (HBAS) is an indicator of vessel occlusion on non contrast-enhanced computer tomography (NECT) in acute stroke patients. Since basilar artery occlusion (BAO) is associated with a high mortality and morbidity, its early detection is of great clinical value. We sought to analyze the influence of density measurement as well as a normalized ratio of Hounsfield unit/hematocrit (HU/Hct) ratio on the detection of BAO on NECT in patients with suspected BAO.MATERIALS AND METHODS: 102 patients with clinically suspected BAO were examined with NECT followed immediately by Multidetector computed tomography Angiography. Two observers independently analyzed the images regarding the presence or absence of HBAS on NECT and performed HU measurements in the basilar artery. Receiver operating characteristic curve analysis was performed to determine the optimal density threshold for BAO using attenuation measurements or HU/Hct ratio.RESULTS: Sensitivity of visual detection of the HBAS on NECT was relatively low 81% (95%-CI, 54-95%) while specificity was high 91% (95%-CI, 82-96%). The highest sensitivity was achieved by the combination of visual assessment and additional quantitative attenuation measurements applying a cut-off value of 46.5 HU with 94% sensitivity and 81% specificity for BAO. A HU/Hct ratio >1.32 revealed sensitivity of 88% (95%-CI, 60-98%) and specificity of 84% (95%-CI, 74-90%).CONCLUSION: In patients with clinically suspected acute BAO the combination of visual assessment and additional attenuation measurement with a cut-off value of 46.5 HU is a reliable approach with high sensitivity in the detection of BAO on NECT.

AB - PURPOSE: The hyperdense basilar artery sign (HBAS) is an indicator of vessel occlusion on non contrast-enhanced computer tomography (NECT) in acute stroke patients. Since basilar artery occlusion (BAO) is associated with a high mortality and morbidity, its early detection is of great clinical value. We sought to analyze the influence of density measurement as well as a normalized ratio of Hounsfield unit/hematocrit (HU/Hct) ratio on the detection of BAO on NECT in patients with suspected BAO.MATERIALS AND METHODS: 102 patients with clinically suspected BAO were examined with NECT followed immediately by Multidetector computed tomography Angiography. Two observers independently analyzed the images regarding the presence or absence of HBAS on NECT and performed HU measurements in the basilar artery. Receiver operating characteristic curve analysis was performed to determine the optimal density threshold for BAO using attenuation measurements or HU/Hct ratio.RESULTS: Sensitivity of visual detection of the HBAS on NECT was relatively low 81% (95%-CI, 54-95%) while specificity was high 91% (95%-CI, 82-96%). The highest sensitivity was achieved by the combination of visual assessment and additional quantitative attenuation measurements applying a cut-off value of 46.5 HU with 94% sensitivity and 81% specificity for BAO. A HU/Hct ratio >1.32 revealed sensitivity of 88% (95%-CI, 60-98%) and specificity of 84% (95%-CI, 74-90%).CONCLUSION: In patients with clinically suspected acute BAO the combination of visual assessment and additional attenuation measurement with a cut-off value of 46.5 HU is a reliable approach with high sensitivity in the detection of BAO on NECT.

U2 - 10.1371/journal.pone.0141096

DO - 10.1371/journal.pone.0141096

M3 - SCORING: Journal article

C2 - 26479718

VL - 10

SP - Art. e0141096

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 10

ER -