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Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using Indocyanine Green Fluorescence Imaging

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Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using Indocyanine Green Fluorescence Imaging. / Al-Dam, Ahmed; Precht, Clarissa; Barbe, Armelle; Kohlmeier, Carsten; Hanken, Henning; Wikner, Johannes; Schön, Gerhard; Heiland, Max; Assaf, Alexandre T.

In: J CRANIO MAXILL SURG, Vol. 46, No. 8, 08.2018, p. 1379-1384.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Al-Dam, A, Precht, C, Barbe, A, Kohlmeier, C, Hanken, H, Wikner, J, Schön, G, Heiland, M & Assaf, AT 2018, 'Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using Indocyanine Green Fluorescence Imaging', J CRANIO MAXILL SURG, vol. 46, no. 8, pp. 1379-1384. https://doi.org/10.1016/j.jcms.2018.05.039

APA

Al-Dam, A., Precht, C., Barbe, A., Kohlmeier, C., Hanken, H., Wikner, J., Schön, G., Heiland, M., & Assaf, A. T. (2018). Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using Indocyanine Green Fluorescence Imaging. J CRANIO MAXILL SURG, 46(8), 1379-1384. https://doi.org/10.1016/j.jcms.2018.05.039

Vancouver

Al-Dam A, Precht C, Barbe A, Kohlmeier C, Hanken H, Wikner J et al. Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using Indocyanine Green Fluorescence Imaging. J CRANIO MAXILL SURG. 2018 Aug;46(8):1379-1384. https://doi.org/10.1016/j.jcms.2018.05.039

Bibtex

@article{71835ff69f804a0497e3f287383647ee,
title = "Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using Indocyanine Green Fluorescence Imaging",
abstract = "PURPOSE: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer.PATIENTS AND METHODS: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection. Lymph nodes were examined histologically. The endpoint of this study was to investigate the rate of false-negative results in SLNB.RESULTS: Sentinel lymph nodes could be detected after 8.1 min (range 1-22 min). In eight out of 20 cases, lymph node metastases were found during histopathological evaluation of the neck dissection specimen. In four cases a metastasis could be found in the detected SLN (sensitivity 50%). In the other four cases metastases were found in different lymph nodes. Specificity was 100%, positive predictive value 100%, and negative predictive value 75%.CONCLUSION: In this study, reliability of sentinel lymph node biopsy after ICG imaging could not be verified, as there were false-negative results in 50% of the cases. Therefore, SND can still be recommended as for patients with cT1 or cT2 OSCC, and a N0 neck status.",
author = "Ahmed Al-Dam and Clarissa Precht and Armelle Barbe and Carsten Kohlmeier and Henning Hanken and Johannes Wikner and Gerhard Sch{\"o}n and Max Heiland and Assaf, {Alexandre T.}",
note = "doi: 10.1016/j.jcms.2018.05.039",
year = "2018",
month = aug,
doi = "10.1016/j.jcms.2018.05.039",
language = "English",
volume = "46",
pages = "1379--1384",
journal = "J CRANIO MAXILL SURG",
issn = "1010-5182",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using Indocyanine Green Fluorescence Imaging

AU - Al-Dam, Ahmed

AU - Precht, Clarissa

AU - Barbe, Armelle

AU - Kohlmeier, Carsten

AU - Hanken, Henning

AU - Wikner, Johannes

AU - Schön, Gerhard

AU - Heiland, Max

AU - Assaf, Alexandre T.

N1 - doi: 10.1016/j.jcms.2018.05.039

PY - 2018/8

Y1 - 2018/8

N2 - PURPOSE: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer.PATIENTS AND METHODS: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection. Lymph nodes were examined histologically. The endpoint of this study was to investigate the rate of false-negative results in SLNB.RESULTS: Sentinel lymph nodes could be detected after 8.1 min (range 1-22 min). In eight out of 20 cases, lymph node metastases were found during histopathological evaluation of the neck dissection specimen. In four cases a metastasis could be found in the detected SLN (sensitivity 50%). In the other four cases metastases were found in different lymph nodes. Specificity was 100%, positive predictive value 100%, and negative predictive value 75%.CONCLUSION: In this study, reliability of sentinel lymph node biopsy after ICG imaging could not be verified, as there were false-negative results in 50% of the cases. Therefore, SND can still be recommended as for patients with cT1 or cT2 OSCC, and a N0 neck status.

AB - PURPOSE: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer.PATIENTS AND METHODS: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection. Lymph nodes were examined histologically. The endpoint of this study was to investigate the rate of false-negative results in SLNB.RESULTS: Sentinel lymph nodes could be detected after 8.1 min (range 1-22 min). In eight out of 20 cases, lymph node metastases were found during histopathological evaluation of the neck dissection specimen. In four cases a metastasis could be found in the detected SLN (sensitivity 50%). In the other four cases metastases were found in different lymph nodes. Specificity was 100%, positive predictive value 100%, and negative predictive value 75%.CONCLUSION: In this study, reliability of sentinel lymph node biopsy after ICG imaging could not be verified, as there were false-negative results in 50% of the cases. Therefore, SND can still be recommended as for patients with cT1 or cT2 OSCC, and a N0 neck status.

U2 - 10.1016/j.jcms.2018.05.039

DO - 10.1016/j.jcms.2018.05.039

M3 - SCORING: Journal article

C2 - 29907432

VL - 46

SP - 1379

EP - 1384

JO - J CRANIO MAXILL SURG

JF - J CRANIO MAXILL SURG

SN - 1010-5182

IS - 8

ER -