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Semen quality in sub-fertile range for a significant proportion of young men from the general German Population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig

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Semen quality in sub-fertile range for a significant proportion of young men from the general German Population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig. / Paasch, Uwe; Salzbrunn, Andrea; Glander, Hans Juergen; Plambeck, Kai; Salzbrunn, Harald; Grunewald, Sonja; Stucke, Julia; Vierula, Matti; Skakkebaek, Niels E; Jørgensen, Niels.

In: INT J ANDROL, Vol. 31, No. 2, 04.2008, p. 93-102.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Paasch, U, Salzbrunn, A, Glander, HJ, Plambeck, K, Salzbrunn, H, Grunewald, S, Stucke, J, Vierula, M, Skakkebaek, NE & Jørgensen, N 2008, 'Semen quality in sub-fertile range for a significant proportion of young men from the general German Population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig', INT J ANDROL, vol. 31, no. 2, pp. 93-102. https://doi.org/10.1111/j.1365-2605.2007.00860.x

APA

Paasch, U., Salzbrunn, A., Glander, H. J., Plambeck, K., Salzbrunn, H., Grunewald, S., Stucke, J., Vierula, M., Skakkebaek, N. E., & Jørgensen, N. (2008). Semen quality in sub-fertile range for a significant proportion of young men from the general German Population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig. INT J ANDROL, 31(2), 93-102. https://doi.org/10.1111/j.1365-2605.2007.00860.x

Vancouver

Paasch U, Salzbrunn A, Glander HJ, Plambeck K, Salzbrunn H, Grunewald S et al. Semen quality in sub-fertile range for a significant proportion of young men from the general German Population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig. INT J ANDROL. 2008 Apr;31(2):93-102. https://doi.org/10.1111/j.1365-2605.2007.00860.x

Bibtex

@article{4bb0b067eda94336878af703d6e727eb,
title = "Semen quality in sub-fertile range for a significant proportion of young men from the general German Population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig",
abstract = "Population studies have shown that a high proportion of Nordic men may have so poor semen quality that they can be classified as sub-fertile according to international standards. A question is whether the Nordic data are specific for the Nordic countries or they should be seen as an expression of a general trend in Europe. We therefore carried out a prospective study of semen quality of young men raised in the former East Germany (Leipzig) and West Germany (Hamburg). To enable inter-regional comparisons, we utilized a common European research protocol previously used in studies in the Nordic-Baltic region. Three hundred and thirty-four young men representative of the general population from Hamburg, and 457 from Leipzig delivered semen samples, underwent physical examinations and provided information on life-style and reproductive health parameters. The study period in Hamburg was February 2003--July 2004, and in Leipzig July 2003--April 2005. No significant differences were observed in sperm concentration (median 46, 42, and 44 million/mL for men from Hamburg, Leipzig and the combined Hamburg-Leipzig group respectively) or total sperm count (154,141 and 149 million), whereas the differences for morphologically normal spermatozoa (9.4 and 8.4%) and motile spermatozoa (67 and 81%) were significantly different. Previously published studies have shown reduced fertility with decreasing sperm concentrations below 40-55 millions/mL and normal sperm morphology below 9-19%. Thus, a large fraction of young German men seem to have impaired semen quality that may reduce their natural fertility. However, it remains to be investigated to what extent poor semen quality contributes to the low German fertility rates.",
keywords = "Fertility, Fluorescent Antibody Technique, Follicle Stimulating Hormone, Germany, Humans, Luteinizing Hormone, Male, Semen, Sex Hormone-Binding Globulin, Surveys and Questionnaires, Testosterone, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't",
author = "Uwe Paasch and Andrea Salzbrunn and Glander, {Hans Juergen} and Kai Plambeck and Harald Salzbrunn and Sonja Grunewald and Julia Stucke and Matti Vierula and Skakkebaek, {Niels E} and Niels J{\o}rgensen",
year = "2008",
month = apr,
doi = "10.1111/j.1365-2605.2007.00860.x",
language = "English",
volume = "31",
pages = "93--102",
number = "2",

}

RIS

TY - JOUR

T1 - Semen quality in sub-fertile range for a significant proportion of young men from the general German Population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig

AU - Paasch, Uwe

AU - Salzbrunn, Andrea

AU - Glander, Hans Juergen

AU - Plambeck, Kai

AU - Salzbrunn, Harald

AU - Grunewald, Sonja

AU - Stucke, Julia

AU - Vierula, Matti

AU - Skakkebaek, Niels E

AU - Jørgensen, Niels

PY - 2008/4

Y1 - 2008/4

N2 - Population studies have shown that a high proportion of Nordic men may have so poor semen quality that they can be classified as sub-fertile according to international standards. A question is whether the Nordic data are specific for the Nordic countries or they should be seen as an expression of a general trend in Europe. We therefore carried out a prospective study of semen quality of young men raised in the former East Germany (Leipzig) and West Germany (Hamburg). To enable inter-regional comparisons, we utilized a common European research protocol previously used in studies in the Nordic-Baltic region. Three hundred and thirty-four young men representative of the general population from Hamburg, and 457 from Leipzig delivered semen samples, underwent physical examinations and provided information on life-style and reproductive health parameters. The study period in Hamburg was February 2003--July 2004, and in Leipzig July 2003--April 2005. No significant differences were observed in sperm concentration (median 46, 42, and 44 million/mL for men from Hamburg, Leipzig and the combined Hamburg-Leipzig group respectively) or total sperm count (154,141 and 149 million), whereas the differences for morphologically normal spermatozoa (9.4 and 8.4%) and motile spermatozoa (67 and 81%) were significantly different. Previously published studies have shown reduced fertility with decreasing sperm concentrations below 40-55 millions/mL and normal sperm morphology below 9-19%. Thus, a large fraction of young German men seem to have impaired semen quality that may reduce their natural fertility. However, it remains to be investigated to what extent poor semen quality contributes to the low German fertility rates.

AB - Population studies have shown that a high proportion of Nordic men may have so poor semen quality that they can be classified as sub-fertile according to international standards. A question is whether the Nordic data are specific for the Nordic countries or they should be seen as an expression of a general trend in Europe. We therefore carried out a prospective study of semen quality of young men raised in the former East Germany (Leipzig) and West Germany (Hamburg). To enable inter-regional comparisons, we utilized a common European research protocol previously used in studies in the Nordic-Baltic region. Three hundred and thirty-four young men representative of the general population from Hamburg, and 457 from Leipzig delivered semen samples, underwent physical examinations and provided information on life-style and reproductive health parameters. The study period in Hamburg was February 2003--July 2004, and in Leipzig July 2003--April 2005. No significant differences were observed in sperm concentration (median 46, 42, and 44 million/mL for men from Hamburg, Leipzig and the combined Hamburg-Leipzig group respectively) or total sperm count (154,141 and 149 million), whereas the differences for morphologically normal spermatozoa (9.4 and 8.4%) and motile spermatozoa (67 and 81%) were significantly different. Previously published studies have shown reduced fertility with decreasing sperm concentrations below 40-55 millions/mL and normal sperm morphology below 9-19%. Thus, a large fraction of young German men seem to have impaired semen quality that may reduce their natural fertility. However, it remains to be investigated to what extent poor semen quality contributes to the low German fertility rates.

KW - Fertility

KW - Fluorescent Antibody Technique

KW - Follicle Stimulating Hormone

KW - Germany

KW - Humans

KW - Luteinizing Hormone

KW - Male

KW - Semen

KW - Sex Hormone-Binding Globulin

KW - Surveys and Questionnaires

KW - Testosterone

KW - Controlled Clinical Trial

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/j.1365-2605.2007.00860.x

DO - 10.1111/j.1365-2605.2007.00860.x

M3 - SCORING: Journal article

C2 - 18315714

VL - 31

SP - 93

EP - 102

IS - 2

ER -