Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease
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Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease. / Ferrer, I; Freixas, M; Blanco, R; Carmona, M; Puig, B; Puig Martorell, Berta.
In: NEUROPATH APPL NEURO, Vol. 30, No. 4, 01.08.2004, p. 329-37.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease
AU - Ferrer, I
AU - Freixas, M
AU - Blanco, R
AU - Carmona, M
AU - Puig, B
AU - Puig Martorell, Berta
PY - 2004/8/1
Y1 - 2004/8/1
N2 - Doppel (Dpl) is a prion-like protein encoded by the gene PRND, which has been found downstream of the prion gene PRNP in several species. The present study examines by immunohistochemistry Dpl expression in brain samples from 10 patients with Alzheimer's disease (AD), three patients with Pick's disease, four patients with Parkinson's disease, eight patients with diffuse Lewy body disease (DLBD), six patients with sporadic Creutzfeldt-Jakob disease (CJD) methionine/methionine at the codon 129, two patients with sporadic CJD methionine/valine at the codon 129 and numerous kuru plaques in the cerebellum, one patient with fatal familial insomnia (FFI), and 10 age-matched controls. In the adult human brain, Dpl immunoreactivity was restricted to scattered granule cells of the cerebellum and scattered small granules in the cerebral cortex. Dpl immunoreactivity was seen around betaA4 amyloid deposits in neuritic plaques, but not in diffuse plaques, AD and the common form of DLBD. Neurofibrillary tangles, Pick bodies and Lewy bodies were not stained with anti-Dpl antibodies. No modifications in Dpl immunoreactivity were observed in CJD excepting those associated with accompanying senile plaques. No Dpl-positive deposits were seen in FFI. Whether Dpl in neuritic plaques may attenuate amyloid-induced oxidative stress and participate in the glial response around amyloid cores is discussed in light of the few available data on Dpl functions.
AB - Doppel (Dpl) is a prion-like protein encoded by the gene PRND, which has been found downstream of the prion gene PRNP in several species. The present study examines by immunohistochemistry Dpl expression in brain samples from 10 patients with Alzheimer's disease (AD), three patients with Pick's disease, four patients with Parkinson's disease, eight patients with diffuse Lewy body disease (DLBD), six patients with sporadic Creutzfeldt-Jakob disease (CJD) methionine/methionine at the codon 129, two patients with sporadic CJD methionine/valine at the codon 129 and numerous kuru plaques in the cerebellum, one patient with fatal familial insomnia (FFI), and 10 age-matched controls. In the adult human brain, Dpl immunoreactivity was restricted to scattered granule cells of the cerebellum and scattered small granules in the cerebral cortex. Dpl immunoreactivity was seen around betaA4 amyloid deposits in neuritic plaques, but not in diffuse plaques, AD and the common form of DLBD. Neurofibrillary tangles, Pick bodies and Lewy bodies were not stained with anti-Dpl antibodies. No modifications in Dpl immunoreactivity were observed in CJD excepting those associated with accompanying senile plaques. No Dpl-positive deposits were seen in FFI. Whether Dpl in neuritic plaques may attenuate amyloid-induced oxidative stress and participate in the glial response around amyloid cores is discussed in light of the few available data on Dpl functions.
KW - Aged
KW - Aged, 80 and over
KW - Alzheimer Disease
KW - Astrocytes
KW - Brain
KW - Brain Chemistry
KW - Creutzfeldt-Jakob Syndrome
KW - Female
KW - GPI-Linked Proteins
KW - Humans
KW - Immunohistochemistry
KW - Lewy Body Disease
KW - Male
KW - Middle Aged
KW - Neurites
KW - Neurofibrillary Tangles
KW - Parkinson Disease
KW - Pick Disease of the Brain
KW - Plaque, Amyloid
KW - Prions
KW - Testis
U2 - 10.1111/j.1365-2990.2003.00534.x
DO - 10.1111/j.1365-2990.2003.00534.x
M3 - SCORING: Journal article
C2 - 15305978
VL - 30
SP - 329
EP - 337
JO - NEUROPATH APPL NEURO
JF - NEUROPATH APPL NEURO
SN - 0305-1846
IS - 4
ER -