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Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction: In vitro and in vivo results

Standard

Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction: In vitro and in vivo results. / Smeets, Ralf; Barbeck, Mike; Hanken, Henning; Fischer, Horst; Lindner, Markus; Heiland, Max; Wöltje, Michael; Ghanaati, Shahram; Kolk, Andreas.

In: J BIOMED MATER RES B, Vol. 105, No. 5, 07.2017, p. 1216-1231.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Smeets, R, Barbeck, M, Hanken, H, Fischer, H, Lindner, M, Heiland, M, Wöltje, M, Ghanaati, S & Kolk, A 2017, 'Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction: In vitro and in vivo results', J BIOMED MATER RES B, vol. 105, no. 5, pp. 1216-1231. https://doi.org/10.1002/jbm.b.33660

APA

Smeets, R., Barbeck, M., Hanken, H., Fischer, H., Lindner, M., Heiland, M., Wöltje, M., Ghanaati, S., & Kolk, A. (2017). Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction: In vitro and in vivo results. J BIOMED MATER RES B, 105(5), 1216-1231. https://doi.org/10.1002/jbm.b.33660

Vancouver

Smeets R, Barbeck M, Hanken H, Fischer H, Lindner M, Heiland M et al. Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction: In vitro and in vivo results. J BIOMED MATER RES B. 2017 Jul;105(5):1216-1231. https://doi.org/10.1002/jbm.b.33660

Bibtex

@article{178806a35c414de893e52b64c56add89,
title = "Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction: In vitro and in vivo results",
abstract = "OBJECTIVES: Scaffolds (SC) composed of poly(d,l-lactide) and β-tricalcium phosphate of variable pore structures were manufactured by selective laser melting (SLM), which allowed the production of porous interconnected structures promoting cellular adhesion and vascular proliferation. Biocompatibility, rate of osseointegration and new bone formation (NB) were analyzed.MATERIAL AND METHODS: Powder based on the material composition was selective melted by a laser beam allowing layer-by-layer production. Pore size and biocompatibility were tested with mesenchymal stem cells (rMSC) and Saos 2 cells that were cultivated on SCs showing better proliferation, without toxicity, than controls. SCs with a 600- to 700-µm pore diameter proved ideal for fast and reliable cellular and vascular supply throughout the interconnecting pore system. Jaw and calvarial critical-size defects (CSD) with diameters of 5 or 16 mm were drilled in rats and either SLM test SCs (pore diameter 600 µm) or the previously removed autologs bone as controls were (re-) implanted.RESULTS: The SC in vivo led to complete bone ingrowth with minimal inflammatory reaction adjacent to and within the CSD as compared with controls. The SC promoted the differentiation of rMSC into osteoblasts, revealing osteoinductive properties. Promising NB ingrowth of the material was also obtained in the animal study.CONCLUSION: The SC showed complete bony replacement within 30 days in all rats; this ingrowth was significantly superior to that of controls and revealed no signs of significant foreign body reaction. Because of continuous replacement by bone this material composition is ideal for SCs fitting 3D bone defects. {\textcopyright} 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.",
author = "Ralf Smeets and Mike Barbeck and Henning Hanken and Horst Fischer and Markus Lindner and Max Heiland and Michael W{\"o}ltje and Shahram Ghanaati and Andreas Kolk",
note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2017",
month = jul,
doi = "10.1002/jbm.b.33660",
language = "English",
volume = "105",
pages = "1216--1231",
journal = "J BIOMED MATER RES B",
issn = "1552-4973",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction: In vitro and in vivo results

AU - Smeets, Ralf

AU - Barbeck, Mike

AU - Hanken, Henning

AU - Fischer, Horst

AU - Lindner, Markus

AU - Heiland, Max

AU - Wöltje, Michael

AU - Ghanaati, Shahram

AU - Kolk, Andreas

N1 - © 2016 Wiley Periodicals, Inc.

PY - 2017/7

Y1 - 2017/7

N2 - OBJECTIVES: Scaffolds (SC) composed of poly(d,l-lactide) and β-tricalcium phosphate of variable pore structures were manufactured by selective laser melting (SLM), which allowed the production of porous interconnected structures promoting cellular adhesion and vascular proliferation. Biocompatibility, rate of osseointegration and new bone formation (NB) were analyzed.MATERIAL AND METHODS: Powder based on the material composition was selective melted by a laser beam allowing layer-by-layer production. Pore size and biocompatibility were tested with mesenchymal stem cells (rMSC) and Saos 2 cells that were cultivated on SCs showing better proliferation, without toxicity, than controls. SCs with a 600- to 700-µm pore diameter proved ideal for fast and reliable cellular and vascular supply throughout the interconnecting pore system. Jaw and calvarial critical-size defects (CSD) with diameters of 5 or 16 mm were drilled in rats and either SLM test SCs (pore diameter 600 µm) or the previously removed autologs bone as controls were (re-) implanted.RESULTS: The SC in vivo led to complete bone ingrowth with minimal inflammatory reaction adjacent to and within the CSD as compared with controls. The SC promoted the differentiation of rMSC into osteoblasts, revealing osteoinductive properties. Promising NB ingrowth of the material was also obtained in the animal study.CONCLUSION: The SC showed complete bony replacement within 30 days in all rats; this ingrowth was significantly superior to that of controls and revealed no signs of significant foreign body reaction. Because of continuous replacement by bone this material composition is ideal for SCs fitting 3D bone defects. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.

AB - OBJECTIVES: Scaffolds (SC) composed of poly(d,l-lactide) and β-tricalcium phosphate of variable pore structures were manufactured by selective laser melting (SLM), which allowed the production of porous interconnected structures promoting cellular adhesion and vascular proliferation. Biocompatibility, rate of osseointegration and new bone formation (NB) were analyzed.MATERIAL AND METHODS: Powder based on the material composition was selective melted by a laser beam allowing layer-by-layer production. Pore size and biocompatibility were tested with mesenchymal stem cells (rMSC) and Saos 2 cells that were cultivated on SCs showing better proliferation, without toxicity, than controls. SCs with a 600- to 700-µm pore diameter proved ideal for fast and reliable cellular and vascular supply throughout the interconnecting pore system. Jaw and calvarial critical-size defects (CSD) with diameters of 5 or 16 mm were drilled in rats and either SLM test SCs (pore diameter 600 µm) or the previously removed autologs bone as controls were (re-) implanted.RESULTS: The SC in vivo led to complete bone ingrowth with minimal inflammatory reaction adjacent to and within the CSD as compared with controls. The SC promoted the differentiation of rMSC into osteoblasts, revealing osteoinductive properties. Promising NB ingrowth of the material was also obtained in the animal study.CONCLUSION: The SC showed complete bony replacement within 30 days in all rats; this ingrowth was significantly superior to that of controls and revealed no signs of significant foreign body reaction. Because of continuous replacement by bone this material composition is ideal for SCs fitting 3D bone defects. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.

U2 - 10.1002/jbm.b.33660

DO - 10.1002/jbm.b.33660

M3 - SCORING: Journal article

C2 - 27062073

VL - 105

SP - 1216

EP - 1231

JO - J BIOMED MATER RES B

JF - J BIOMED MATER RES B

SN - 1552-4973

IS - 5

ER -