Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina)

Maria Morell; Laura Rojas; Martin Haulena; Björn Busse; Ursula Siebert; Robert E Shadwick; Stephen A Raverty

doi:10.3390/ani12020180

Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina)

Standard

Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina). / Morell, Maria; Rojas, Laura; Haulena, Martin; Busse, Björn; Siebert, Ursula; Shadwick, Robert E; Raverty, Stephen A.

In: ANIMALS-BASEL, Vol. 12, No. 2, 180, 12.01.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Morell, M, Rojas, L, Haulena, M, Busse, B, Siebert, U, Shadwick, RE & Raverty, SA 2022, 'Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina)', ANIMALS-BASEL, vol. 12, no. 2, 180. https://doi.org/10.3390/ani12020180

APA

Morell, M., Rojas, L., Haulena, M., Busse, B., Siebert, U., Shadwick, R. E., & Raverty, S. A. (2022). Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina). ANIMALS-BASEL, 12(2), [180]. https://doi.org/10.3390/ani12020180

Vancouver

Morell M, Rojas L, Haulena M, Busse B, Siebert U, Shadwick RE et al. Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina). ANIMALS-BASEL. 2022 Jan 12;12(2). 180. https://doi.org/10.3390/ani12020180

Bibtex

@article{82a05fc067034f0e94e8daf8267a11a3,

title = "Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina)",

abstract = "Congenital hearing loss is recognized in humans and other terrestrial species. However, there is a lack of information on its prevalence or pathophysiology in pinnipeds. It is important to have baseline knowledge on marine mammal malformations in the inner ear, to differentiate between congenital and acquired abnormalities, which may be caused by infectious pathogens, age, or anthropogenic interactions, such as noise exposure. Ultrastructural evaluation of the cochlea of a neonate harbor seal (Phoca vitulina) by scanning electron microscopy revealed bilateral loss of inner hair cells with intact outer hair cells. The selective inner hair cell loss was more severe in the basal turn, where high-frequency sounds are encoded. The loss of inner hair cells started around 40% away from the apex or tip of the spiral, reaching a maximum loss of 84.6% of hair cells at 80-85% of the length from the apex. Potential etiologies and consequences are discussed. This is believed to be the first case report of selective inner hair cell loss in a marine mammal neonate, likely congenital.",

author = "Maria Morell and Laura Rojas and Martin Haulena and Bj{\"o}rn Busse and Ursula Siebert and Shadwick, {Robert E} and Raverty, {Stephen A}",

year = "2022",

month = jan,

day = "12",

doi = "10.3390/ani12020180",

language = "English",

volume = "12",

journal = "ANIMALS-BASEL",

issn = "2076-2615",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "2",

}

RIS

TY - JOUR

T1 - Selective Inner Hair Cell Loss in a Neonate Harbor Seal (Phoca vitulina)

AU - Morell, Maria

AU - Rojas, Laura

AU - Haulena, Martin

AU - Busse, Björn

AU - Siebert, Ursula

AU - Shadwick, Robert E

AU - Raverty, Stephen A

PY - 2022/1/12

Y1 - 2022/1/12

N2 - Congenital hearing loss is recognized in humans and other terrestrial species. However, there is a lack of information on its prevalence or pathophysiology in pinnipeds. It is important to have baseline knowledge on marine mammal malformations in the inner ear, to differentiate between congenital and acquired abnormalities, which may be caused by infectious pathogens, age, or anthropogenic interactions, such as noise exposure. Ultrastructural evaluation of the cochlea of a neonate harbor seal (Phoca vitulina) by scanning electron microscopy revealed bilateral loss of inner hair cells with intact outer hair cells. The selective inner hair cell loss was more severe in the basal turn, where high-frequency sounds are encoded. The loss of inner hair cells started around 40% away from the apex or tip of the spiral, reaching a maximum loss of 84.6% of hair cells at 80-85% of the length from the apex. Potential etiologies and consequences are discussed. This is believed to be the first case report of selective inner hair cell loss in a marine mammal neonate, likely congenital.

AB - Congenital hearing loss is recognized in humans and other terrestrial species. However, there is a lack of information on its prevalence or pathophysiology in pinnipeds. It is important to have baseline knowledge on marine mammal malformations in the inner ear, to differentiate between congenital and acquired abnormalities, which may be caused by infectious pathogens, age, or anthropogenic interactions, such as noise exposure. Ultrastructural evaluation of the cochlea of a neonate harbor seal (Phoca vitulina) by scanning electron microscopy revealed bilateral loss of inner hair cells with intact outer hair cells. The selective inner hair cell loss was more severe in the basal turn, where high-frequency sounds are encoded. The loss of inner hair cells started around 40% away from the apex or tip of the spiral, reaching a maximum loss of 84.6% of hair cells at 80-85% of the length from the apex. Potential etiologies and consequences are discussed. This is believed to be the first case report of selective inner hair cell loss in a marine mammal neonate, likely congenital.

U2 - 10.3390/ani12020180

DO - 10.3390/ani12020180

M3 - SCORING: Journal article

C2 - 35049802

VL - 12

JO - ANIMALS-BASEL

JF - ANIMALS-BASEL

SN - 2076-2615

IS - 2

M1 - 180

ER -