Selective bilateral hippocampal lesions after theophylline-induced status epilepticus causes a permanent amnesic syndrome.
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Selective bilateral hippocampal lesions after theophylline-induced status epilepticus causes a permanent amnesic syndrome. / Kohl, Z; Uyanik, Gökhan; Lürding, R; Schuierer, G; Bogdahn, U; Schröder, M; Weidner, N.
In: J CLIN NEUROSCI, Vol. 18, No. 7, 7, 2011, p. 964-966.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Selective bilateral hippocampal lesions after theophylline-induced status epilepticus causes a permanent amnesic syndrome.
AU - Kohl, Z
AU - Uyanik, Gökhan
AU - Lürding, R
AU - Schuierer, G
AU - Bogdahn, U
AU - Schröder, M
AU - Weidner, N
PY - 2011
Y1 - 2011
N2 - Theophylline is known to increase the risk of epileptic seizures and might have a role in seizure-induced brain damage. We present a 55-year-old man who developed an amnesic syndrome after status epilepticus, caused by accidental theophylline intoxication. Imaging studies revealed acute, selective bilateral hippocampal damage, which corresponded to severe disturbances in bilateral temporal functions on neuropsychological testing. Three months later, the memory deficits persisted, while imaging exhibited bilateral atrophy of the hippocampus. Upon his long-term, 18-month follow-up, the patient demonstrated improvements in his daily living abilities, despite the persistence of bilateral temporal deficits. This report provides evidence that theophylline has the potential to provoke permanent seizure-induced neural damage, presumably via inhibition of adenosine receptors, and especially in vulnerable regions of the brain, such as the hippocampus.
AB - Theophylline is known to increase the risk of epileptic seizures and might have a role in seizure-induced brain damage. We present a 55-year-old man who developed an amnesic syndrome after status epilepticus, caused by accidental theophylline intoxication. Imaging studies revealed acute, selective bilateral hippocampal damage, which corresponded to severe disturbances in bilateral temporal functions on neuropsychological testing. Three months later, the memory deficits persisted, while imaging exhibited bilateral atrophy of the hippocampus. Upon his long-term, 18-month follow-up, the patient demonstrated improvements in his daily living abilities, despite the persistence of bilateral temporal deficits. This report provides evidence that theophylline has the potential to provoke permanent seizure-induced neural damage, presumably via inhibition of adenosine receptors, and especially in vulnerable regions of the brain, such as the hippocampus.
KW - Humans
KW - Male
KW - Middle Aged
KW - Magnetic Resonance Imaging
KW - Syndrome
KW - Hippocampus/pathology
KW - Amnesia/chemically induced/pathology
KW - Bronchodilator Agents/adverse effects
KW - Lung Diseases, Obstructive/drug therapy
KW - Status Epilepticus/chemically induced
KW - Theophylline/adverse effects
KW - Humans
KW - Male
KW - Middle Aged
KW - Magnetic Resonance Imaging
KW - Syndrome
KW - Hippocampus/pathology
KW - Amnesia/chemically induced/pathology
KW - Bronchodilator Agents/adverse effects
KW - Lung Diseases, Obstructive/drug therapy
KW - Status Epilepticus/chemically induced
KW - Theophylline/adverse effects
M3 - SCORING: Journal article
VL - 18
SP - 964
EP - 966
JO - J CLIN NEUROSCI
JF - J CLIN NEUROSCI
SN - 0967-5868
IS - 7
M1 - 7
ER -
