Segregating cognitive functions within hippocampal formation
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Segregating cognitive functions within hippocampal formation : a quantitative meta-analysis on spatial navigation and episodic memory. / Kühn, Simone; Gallinat, Jürgen.
In: HUM BRAIN MAPP, Vol. 35, No. 4, 04.2014, p. 1129-42.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Segregating cognitive functions within hippocampal formation
T2 - a quantitative meta-analysis on spatial navigation and episodic memory
AU - Kühn, Simone
AU - Gallinat, Jürgen
N1 - Copyright © 2013 Wiley Periodicals, Inc.
PY - 2014/4
Y1 - 2014/4
N2 - The most important cognitive domains where hippocampal formation is crucially involved are navigation and memory. Some evidence suggests that different hippocampal subregions mediate these domains. However, a quantitative meta-analysis on neuroimaging studies of spatial navigation versus memory is lacking. By means of activation likelihood estimation (ALE), we investigate concurrence of brain regions activated during spatial navigation encoding and retrieval as well as during episodic memory encoding and retrieval tasks in humans. During encoding in spatial navigation, activity was located in more posterior regions of the hippocampal formation, whereas episodic memory encoding was located in more anterior regions. Retrieval in spatial navigation was more strongly lateralized to the right compared to episodic memory retrieval. Within studies on spatial navigation retrieval, immediate recall was located more posterior and delayed recall more anterior. Overlap between concurrence of activation in spatial navigation and episodic memory was rather limited in comparison to uniquely involved regions. This argues in favor of two distinct networks, one for spatial navigation the other for episodic memory within the hippocampal formation.
AB - The most important cognitive domains where hippocampal formation is crucially involved are navigation and memory. Some evidence suggests that different hippocampal subregions mediate these domains. However, a quantitative meta-analysis on neuroimaging studies of spatial navigation versus memory is lacking. By means of activation likelihood estimation (ALE), we investigate concurrence of brain regions activated during spatial navigation encoding and retrieval as well as during episodic memory encoding and retrieval tasks in humans. During encoding in spatial navigation, activity was located in more posterior regions of the hippocampal formation, whereas episodic memory encoding was located in more anterior regions. Retrieval in spatial navigation was more strongly lateralized to the right compared to episodic memory retrieval. Within studies on spatial navigation retrieval, immediate recall was located more posterior and delayed recall more anterior. Overlap between concurrence of activation in spatial navigation and episodic memory was rather limited in comparison to uniquely involved regions. This argues in favor of two distinct networks, one for spatial navigation the other for episodic memory within the hippocampal formation.
KW - Brain Mapping
KW - Hippocampus
KW - Humans
KW - Likelihood Functions
KW - Magnetic Resonance Imaging
KW - Memory, Episodic
KW - Mental Recall
KW - Positron-Emission Tomography
KW - Space Perception
KW - Time Factors
U2 - 10.1002/hbm.22239
DO - 10.1002/hbm.22239
M3 - SCORING: Journal article
C2 - 23362184
VL - 35
SP - 1129
EP - 1142
JO - HUM BRAIN MAPP
JF - HUM BRAIN MAPP
SN - 1065-9471
IS - 4
ER -
