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Screening for late preeclampsia at 35-37 weeks by the urinary Congo-red dot paper test

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Screening for late preeclampsia at 35-37 weeks by the urinary Congo-red dot paper test. / Döbert, Moritz; Varouxaki, Anna-Nektaria; Mu, An Chi; Syngelaki, Argyro; Nicolaides, Kypros H.

In: J MATERN-FETAL NEO M, Vol. 35, No. 25, 12.2022, p. 5686-5690.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Döbert, M, Varouxaki, A-N, Mu, AC, Syngelaki, A & Nicolaides, KH 2022, 'Screening for late preeclampsia at 35-37 weeks by the urinary Congo-red dot paper test', J MATERN-FETAL NEO M, vol. 35, no. 25, pp. 5686-5690. https://doi.org/10.1080/14767058.2021.1888924

APA

Döbert, M., Varouxaki, A-N., Mu, A. C., Syngelaki, A., & Nicolaides, K. H. (2022). Screening for late preeclampsia at 35-37 weeks by the urinary Congo-red dot paper test. J MATERN-FETAL NEO M, 35(25), 5686-5690. https://doi.org/10.1080/14767058.2021.1888924

Vancouver

Döbert M, Varouxaki A-N, Mu AC, Syngelaki A, Nicolaides KH. Screening for late preeclampsia at 35-37 weeks by the urinary Congo-red dot paper test. J MATERN-FETAL NEO M. 2022 Dec;35(25):5686-5690. https://doi.org/10.1080/14767058.2021.1888924

Bibtex

@article{30831fd5b02349b4b3d630f0daa08b23,
title = "Screening for late preeclampsia at 35-37 weeks by the urinary Congo-red dot paper test",
abstract = "BACKGROUND: Several cross-sectional studies have investigated the incidence of urinary Congo-red dye positivity in women with preeclampsia (PE), compared to unaffected pregnancies, and reported very high sensitivity and low false positive rate in the diagnosis of PE.OBJECTIVE: To determine the performance of the urinary Congo-red dot paper test at 35-37 weeks' gestation in the prediction of delivery with PE at ≤2 and >2 weeks after assessment.METHODS: This was a prospective observational study in women attending for a routine hospital visit at 35+0 to 36+6 weeks' gestation in a maternity hospital in England. Urine samples were collected and the Congo-red dot paper test was used to assess the degree of Congo-red dye positivity. The test uses a scoring system from 1 to 8 and the higher the score the greater the degree of Congo-red dye positivity. We examined and compared the degree of Congo-red dye positivity in the groups that delivered with PE at ≤2 and >2 weeks with those that remained normotensive. Reproducibility was assessed by examining the inter- and intra-observer reliability of scoring on stored images with the researchers blinded to previous results.RESULTS: The study population of 2140 women included 46 (2.1%) that subsequently developed PE (2.1%). The urinary Congo-red dot test was positive in 8.3% (1/12) and 2.9% (1/34) that delivered with PE at ≤2 and >2 weeks from assessment and in 0.2% (4/2094) of the unaffected pregnancies when the cutoff for Congo-red dye positivity was ≥5. The respective values when the cutoff used was ≥3 were 66.7%, 23.5%, and 16.5%, respectively. The intraclass correlation coefficient for the inter-observer reliability was 0.926 (95% CI 0.890-0.953, p<.0001) and Cohen's kappa coefficient for the intra-observer reliability was 0.904, p<.0001.CONCLUSIONS: The performance of the urinary Congo-red dot paper test at 35-37 weeks' gestation in the prediction of PE is very poor.",
author = "Moritz D{\"o}bert and Anna-Nektaria Varouxaki and Mu, {An Chi} and Argyro Syngelaki and Nicolaides, {Kypros H}",
year = "2022",
month = dec,
doi = "10.1080/14767058.2021.1888924",
language = "English",
volume = "35",
pages = "5686--5690",
journal = "J MATERN-FETAL NEO M",
issn = "1476-7058",
publisher = "informa healthcare",
number = "25",

}

RIS

TY - JOUR

T1 - Screening for late preeclampsia at 35-37 weeks by the urinary Congo-red dot paper test

AU - Döbert, Moritz

AU - Varouxaki, Anna-Nektaria

AU - Mu, An Chi

AU - Syngelaki, Argyro

AU - Nicolaides, Kypros H

PY - 2022/12

Y1 - 2022/12

N2 - BACKGROUND: Several cross-sectional studies have investigated the incidence of urinary Congo-red dye positivity in women with preeclampsia (PE), compared to unaffected pregnancies, and reported very high sensitivity and low false positive rate in the diagnosis of PE.OBJECTIVE: To determine the performance of the urinary Congo-red dot paper test at 35-37 weeks' gestation in the prediction of delivery with PE at ≤2 and >2 weeks after assessment.METHODS: This was a prospective observational study in women attending for a routine hospital visit at 35+0 to 36+6 weeks' gestation in a maternity hospital in England. Urine samples were collected and the Congo-red dot paper test was used to assess the degree of Congo-red dye positivity. The test uses a scoring system from 1 to 8 and the higher the score the greater the degree of Congo-red dye positivity. We examined and compared the degree of Congo-red dye positivity in the groups that delivered with PE at ≤2 and >2 weeks with those that remained normotensive. Reproducibility was assessed by examining the inter- and intra-observer reliability of scoring on stored images with the researchers blinded to previous results.RESULTS: The study population of 2140 women included 46 (2.1%) that subsequently developed PE (2.1%). The urinary Congo-red dot test was positive in 8.3% (1/12) and 2.9% (1/34) that delivered with PE at ≤2 and >2 weeks from assessment and in 0.2% (4/2094) of the unaffected pregnancies when the cutoff for Congo-red dye positivity was ≥5. The respective values when the cutoff used was ≥3 were 66.7%, 23.5%, and 16.5%, respectively. The intraclass correlation coefficient for the inter-observer reliability was 0.926 (95% CI 0.890-0.953, p<.0001) and Cohen's kappa coefficient for the intra-observer reliability was 0.904, p<.0001.CONCLUSIONS: The performance of the urinary Congo-red dot paper test at 35-37 weeks' gestation in the prediction of PE is very poor.

AB - BACKGROUND: Several cross-sectional studies have investigated the incidence of urinary Congo-red dye positivity in women with preeclampsia (PE), compared to unaffected pregnancies, and reported very high sensitivity and low false positive rate in the diagnosis of PE.OBJECTIVE: To determine the performance of the urinary Congo-red dot paper test at 35-37 weeks' gestation in the prediction of delivery with PE at ≤2 and >2 weeks after assessment.METHODS: This was a prospective observational study in women attending for a routine hospital visit at 35+0 to 36+6 weeks' gestation in a maternity hospital in England. Urine samples were collected and the Congo-red dot paper test was used to assess the degree of Congo-red dye positivity. The test uses a scoring system from 1 to 8 and the higher the score the greater the degree of Congo-red dye positivity. We examined and compared the degree of Congo-red dye positivity in the groups that delivered with PE at ≤2 and >2 weeks with those that remained normotensive. Reproducibility was assessed by examining the inter- and intra-observer reliability of scoring on stored images with the researchers blinded to previous results.RESULTS: The study population of 2140 women included 46 (2.1%) that subsequently developed PE (2.1%). The urinary Congo-red dot test was positive in 8.3% (1/12) and 2.9% (1/34) that delivered with PE at ≤2 and >2 weeks from assessment and in 0.2% (4/2094) of the unaffected pregnancies when the cutoff for Congo-red dye positivity was ≥5. The respective values when the cutoff used was ≥3 were 66.7%, 23.5%, and 16.5%, respectively. The intraclass correlation coefficient for the inter-observer reliability was 0.926 (95% CI 0.890-0.953, p<.0001) and Cohen's kappa coefficient for the intra-observer reliability was 0.904, p<.0001.CONCLUSIONS: The performance of the urinary Congo-red dot paper test at 35-37 weeks' gestation in the prediction of PE is very poor.

U2 - 10.1080/14767058.2021.1888924

DO - 10.1080/14767058.2021.1888924

M3 - SCORING: Journal article

C2 - 34182860

VL - 35

SP - 5686

EP - 5690

JO - J MATERN-FETAL NEO M

JF - J MATERN-FETAL NEO M

SN - 1476-7058

IS - 25

ER -