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Scent dog identification of SARS-CoV-2 infections in different body fluids

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Scent dog identification of SARS-CoV-2 infections in different body fluids. / Jendrny, Paula; Twele, Friederike; Meller, Sebastian; Schulz, Claudia; von Köckritz-Blickwede, Maren; Osterhaus, Albertus Dominicus Marcellinus Eras; Ebbers, Hans; Ebbers, Janek; Pilchová, Veronika; Pink, Isabell; Welte, Tobias; Manns, Michael Peter; Fathi, Anahita; Addo, Marylyn Martina; Ernst, Christiane; Schäfer, Wencke; Engels, Michael; Petrov, Anja; Marquart, Katharina; Schotte, Ulrich; Schalke, Esther; Volk, Holger Andreas.

In: BMC INFECT DIS, Vol. 21, No. 1, 707, 27.07.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jendrny, P, Twele, F, Meller, S, Schulz, C, von Köckritz-Blickwede, M, Osterhaus, ADME, Ebbers, H, Ebbers, J, Pilchová, V, Pink, I, Welte, T, Manns, MP, Fathi, A, Addo, MM, Ernst, C, Schäfer, W, Engels, M, Petrov, A, Marquart, K, Schotte, U, Schalke, E & Volk, HA 2021, 'Scent dog identification of SARS-CoV-2 infections in different body fluids', BMC INFECT DIS, vol. 21, no. 1, 707. https://doi.org/10.1186/s12879-021-06411-1

APA

Jendrny, P., Twele, F., Meller, S., Schulz, C., von Köckritz-Blickwede, M., Osterhaus, A. D. M. E., Ebbers, H., Ebbers, J., Pilchová, V., Pink, I., Welte, T., Manns, M. P., Fathi, A., Addo, M. M., Ernst, C., Schäfer, W., Engels, M., Petrov, A., Marquart, K., ... Volk, H. A. (2021). Scent dog identification of SARS-CoV-2 infections in different body fluids. BMC INFECT DIS, 21(1), [707]. https://doi.org/10.1186/s12879-021-06411-1

Vancouver

Jendrny P, Twele F, Meller S, Schulz C, von Köckritz-Blickwede M, Osterhaus ADME et al. Scent dog identification of SARS-CoV-2 infections in different body fluids. BMC INFECT DIS. 2021 Jul 27;21(1). 707. https://doi.org/10.1186/s12879-021-06411-1

Bibtex

@article{225ea3e4acd5458da93dc108e3f2dbbe,
title = "Scent dog identification of SARS-CoV-2 infections in different body fluids",
abstract = "BACKGROUND: The main strategy to contain the current SARS-CoV-2 pandemic remains to implement a comprehensive testing, tracing and quarantining strategy until vaccination of the population is adequate. Scent dogs could support current testing strategies.METHODS: Ten dogs were trained for 8 days to detect SARS-CoV-2 infections in beta-propiolactone inactivated saliva samples. The subsequent cognitive transfer performance for the recognition of non-inactivated samples were tested on three different body fluids (saliva, urine, and sweat) in a randomised, double-blind controlled study.RESULTS: Dogs were tested on a total of 5242 randomised sample presentations. Dogs detected non-inactivated saliva samples with a diagnostic sensitivity of 84% (95% CI: 62.5-94.44%) and specificity of 95% (95% CI: 93.4-96%). In a subsequent experiment to compare the scent recognition between the three non-inactivated body fluids, diagnostic sensitivity and specificity were 95% (95% CI: 66.67-100%) and 98% (95% CI: 94.87-100%) for urine, 91% (95% CI: 71.43-100%) and 94% (95% CI: 90.91-97.78%) for sweat, 82% (95% CI: 64.29-95.24%), and 96% (95% CI: 94.95-98.9%) for saliva respectively.CONCLUSIONS: The scent cognitive transfer performance between inactivated and non-inactivated samples as well as between different sample materials indicates that global, specific SARS-CoV-2-associated volatile compounds are released across different body secretions, independently from the patient's symptoms. All tested body fluids appear to be similarly suited for reliable detection of SARS-CoV-2 infected individuals.",
keywords = "Animals, Body Fluids, COVID-19, Dogs, Humans, Odorants, Pandemics, SARS-CoV-2, Saliva",
author = "Paula Jendrny and Friederike Twele and Sebastian Meller and Claudia Schulz and {von K{\"o}ckritz-Blickwede}, Maren and Osterhaus, {Albertus Dominicus Marcellinus Eras} and Hans Ebbers and Janek Ebbers and Veronika Pilchov{\'a} and Isabell Pink and Tobias Welte and Manns, {Michael Peter} and Anahita Fathi and Addo, {Marylyn Martina} and Christiane Ernst and Wencke Sch{\"a}fer and Michael Engels and Anja Petrov and Katharina Marquart and Ulrich Schotte and Esther Schalke and Volk, {Holger Andreas}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = jul,
day = "27",
doi = "10.1186/s12879-021-06411-1",
language = "English",
volume = "21",
journal = "BMC INFECT DIS",
issn = "1471-2334",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Scent dog identification of SARS-CoV-2 infections in different body fluids

AU - Jendrny, Paula

AU - Twele, Friederike

AU - Meller, Sebastian

AU - Schulz, Claudia

AU - von Köckritz-Blickwede, Maren

AU - Osterhaus, Albertus Dominicus Marcellinus Eras

AU - Ebbers, Hans

AU - Ebbers, Janek

AU - Pilchová, Veronika

AU - Pink, Isabell

AU - Welte, Tobias

AU - Manns, Michael Peter

AU - Fathi, Anahita

AU - Addo, Marylyn Martina

AU - Ernst, Christiane

AU - Schäfer, Wencke

AU - Engels, Michael

AU - Petrov, Anja

AU - Marquart, Katharina

AU - Schotte, Ulrich

AU - Schalke, Esther

AU - Volk, Holger Andreas

N1 - © 2021. The Author(s).

PY - 2021/7/27

Y1 - 2021/7/27

N2 - BACKGROUND: The main strategy to contain the current SARS-CoV-2 pandemic remains to implement a comprehensive testing, tracing and quarantining strategy until vaccination of the population is adequate. Scent dogs could support current testing strategies.METHODS: Ten dogs were trained for 8 days to detect SARS-CoV-2 infections in beta-propiolactone inactivated saliva samples. The subsequent cognitive transfer performance for the recognition of non-inactivated samples were tested on three different body fluids (saliva, urine, and sweat) in a randomised, double-blind controlled study.RESULTS: Dogs were tested on a total of 5242 randomised sample presentations. Dogs detected non-inactivated saliva samples with a diagnostic sensitivity of 84% (95% CI: 62.5-94.44%) and specificity of 95% (95% CI: 93.4-96%). In a subsequent experiment to compare the scent recognition between the three non-inactivated body fluids, diagnostic sensitivity and specificity were 95% (95% CI: 66.67-100%) and 98% (95% CI: 94.87-100%) for urine, 91% (95% CI: 71.43-100%) and 94% (95% CI: 90.91-97.78%) for sweat, 82% (95% CI: 64.29-95.24%), and 96% (95% CI: 94.95-98.9%) for saliva respectively.CONCLUSIONS: The scent cognitive transfer performance between inactivated and non-inactivated samples as well as between different sample materials indicates that global, specific SARS-CoV-2-associated volatile compounds are released across different body secretions, independently from the patient's symptoms. All tested body fluids appear to be similarly suited for reliable detection of SARS-CoV-2 infected individuals.

AB - BACKGROUND: The main strategy to contain the current SARS-CoV-2 pandemic remains to implement a comprehensive testing, tracing and quarantining strategy until vaccination of the population is adequate. Scent dogs could support current testing strategies.METHODS: Ten dogs were trained for 8 days to detect SARS-CoV-2 infections in beta-propiolactone inactivated saliva samples. The subsequent cognitive transfer performance for the recognition of non-inactivated samples were tested on three different body fluids (saliva, urine, and sweat) in a randomised, double-blind controlled study.RESULTS: Dogs were tested on a total of 5242 randomised sample presentations. Dogs detected non-inactivated saliva samples with a diagnostic sensitivity of 84% (95% CI: 62.5-94.44%) and specificity of 95% (95% CI: 93.4-96%). In a subsequent experiment to compare the scent recognition between the three non-inactivated body fluids, diagnostic sensitivity and specificity were 95% (95% CI: 66.67-100%) and 98% (95% CI: 94.87-100%) for urine, 91% (95% CI: 71.43-100%) and 94% (95% CI: 90.91-97.78%) for sweat, 82% (95% CI: 64.29-95.24%), and 96% (95% CI: 94.95-98.9%) for saliva respectively.CONCLUSIONS: The scent cognitive transfer performance between inactivated and non-inactivated samples as well as between different sample materials indicates that global, specific SARS-CoV-2-associated volatile compounds are released across different body secretions, independently from the patient's symptoms. All tested body fluids appear to be similarly suited for reliable detection of SARS-CoV-2 infected individuals.

KW - Animals

KW - Body Fluids

KW - COVID-19

KW - Dogs

KW - Humans

KW - Odorants

KW - Pandemics

KW - SARS-CoV-2

KW - Saliva

U2 - 10.1186/s12879-021-06411-1

DO - 10.1186/s12879-021-06411-1

M3 - SCORING: Journal article

C2 - 34315418

VL - 21

JO - BMC INFECT DIS

JF - BMC INFECT DIS

SN - 1471-2334

IS - 1

M1 - 707

ER -