Scaffold-free microtissues: differences from monolayer cultures and their potential in bone tissue engineering.
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Scaffold-free microtissues: differences from monolayer cultures and their potential in bone tissue engineering. / Langenbach, Fabian; Naujoks, Christian; Smeets, Ralf; Berr, Karin; Depprich, Rita; Kübler, Norbert; Handschel, Jörg.
In: CLIN ORAL INVEST, Vol. 17, No. 1, 1, 2013, p. 9-17.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Scaffold-free microtissues: differences from monolayer cultures and their potential in bone tissue engineering.
AU - Langenbach, Fabian
AU - Naujoks, Christian
AU - Smeets, Ralf
AU - Berr, Karin
AU - Depprich, Rita
AU - Kübler, Norbert
AU - Handschel, Jörg
PY - 2013
Y1 - 2013
N2 - Cell-based therapies for bone augmentation after tooth loss and for the treatment of periodontal defects improve healing defects. Usually, osteogenic cells or stem cells are cultivated in 2D primary cultures, before they are combined with scaffold materials, even though this means a loss of the endogenous 3D microenvironment for the cells. Moreover, the use of single-cell suspensions for the inoculation of scaffolds or for the direct application into an area of interest has the disadvantages of low initial cell numbers and susceptibility to unwanted cellular distribution, respectively.
AB - Cell-based therapies for bone augmentation after tooth loss and for the treatment of periodontal defects improve healing defects. Usually, osteogenic cells or stem cells are cultivated in 2D primary cultures, before they are combined with scaffold materials, even though this means a loss of the endogenous 3D microenvironment for the cells. Moreover, the use of single-cell suspensions for the inoculation of scaffolds or for the direct application into an area of interest has the disadvantages of low initial cell numbers and susceptibility to unwanted cellular distribution, respectively.
M3 - SCORING: Journal article
VL - 17
SP - 9
EP - 17
JO - CLIN ORAL INVEST
JF - CLIN ORAL INVEST
SN - 1432-6981
IS - 1
M1 - 1
ER -