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SARS-CoV-2-associated T-cell infiltration in the central nervous system

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SARS-CoV-2-associated T-cell infiltration in the central nervous system. / Mohme, Malte; Schultheiß, Christoph; Piffko, Andras; Fitzek, Antonia; Paschold, Lisa; Thiele, Benjamin; Püschel, Klaus; Glatzel, Markus; Westphal, Manfred; Lamszus, Katrin; Matschke, Jakob; Binder, Mascha.

In: CLIN TRANSL IMMUNOL, Vol. 13, No. 2, 2024, p. e1487.

Research output: SCORING: Contribution to journal › Short publication › Research › peer-review

Harvard

Mohme, M, Schultheiß, C, Piffko, A, Fitzek, A, Paschold, L, Thiele, B, Püschel, K, Glatzel, M, Westphal, M, Lamszus, K, Matschke, J & Binder, M 2024, 'SARS-CoV-2-associated T-cell infiltration in the central nervous system', CLIN TRANSL IMMUNOL, vol. 13, no. 2, pp. e1487. https://doi.org/10.1002/cti2.1487

APA

Mohme, M., Schultheiß, C., Piffko, A., Fitzek, A., Paschold, L., Thiele, B., Püschel, K., Glatzel, M., Westphal, M., Lamszus, K., Matschke, J., & Binder, M. (2024). SARS-CoV-2-associated T-cell infiltration in the central nervous system. CLIN TRANSL IMMUNOL, 13(2), e1487. https://doi.org/10.1002/cti2.1487

Vancouver

Mohme M, Schultheiß C, Piffko A, Fitzek A, Paschold L, Thiele B et al. SARS-CoV-2-associated T-cell infiltration in the central nervous system. CLIN TRANSL IMMUNOL. 2024;13(2):e1487. https://doi.org/10.1002/cti2.1487

Bibtex

@article{5e5d43c2525540bfa85b4572c0eebb34,
title = "SARS-CoV-2-associated T-cell infiltration in the central nervous system",
abstract = "OBJECTIVES: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Although an acute SARS-CoV-2 infection mainly presents with respiratory illness, neurologic symptoms and sequelae are increasingly recognised in the long-term treatment of COVID-19 patients. The pathophysiology and the neuropathogenesis behind neurologic complications of COVID-19 remain poorly understood, but mounting evidence points to endothelial dysfunction either directly caused by viral infection or indirectly by inflammatory cytokines, followed by a local immune response that may include virus-specific T cells. However, the type and role of central nervous system-infiltrating T cells in COVID-19 are complex and not fully understood.METHODS: We analysed distinct anatomical brain regions of patients who had deceased as a result of COVID-19-associated pneumonia or complications thereof and performed T cell receptor Vβ repertoire sequencing. Clonotypes were analysed for SARS-CoV-2 association using public TCR repertoire data.RESULTS: Our descriptive study demonstrates that SARS-CoV-2-associated T cells are found in almost all brain areas of patients with fatal COVID-19 courses. The olfactory bulb, medulla and cerebellum were brain regions showing the most SARS-CoV-2 specific sequence patterns. Neuropathological workup demonstrated primary CD8+ T-cell infiltration with a perivascular infiltration pattern.CONCLUSION: Future research is needed to better define the relationship between T-cell infiltration and neurological symptoms and its long-term impact on patients' cognitive and mental health.",
author = "Malte Mohme and Christoph Schulthei{\ss} and Andras Piffko and Antonia Fitzek and Lisa Paschold and Benjamin Thiele and Klaus P{\"u}schel and Markus Glatzel and Manfred Westphal and Katrin Lamszus and Jakob Matschke and Mascha Binder",
note = "{\textcopyright} 2024 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.",
year = "2024",
doi = "10.1002/cti2.1487",
language = "English",
volume = "13",
pages = "e1487",
journal = "CLIN TRANSL IMMUNOL",
issn = "2050-0068",
publisher = "John Wiley & Sons Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - SARS-CoV-2-associated T-cell infiltration in the central nervous system

AU - Mohme, Malte

AU - Schultheiß, Christoph

AU - Piffko, Andras

AU - Fitzek, Antonia

AU - Paschold, Lisa

AU - Thiele, Benjamin

AU - Püschel, Klaus

AU - Glatzel, Markus

AU - Westphal, Manfred

AU - Lamszus, Katrin

AU - Matschke, Jakob

AU - Binder, Mascha

N1 - © 2024 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.

PY - 2024

Y1 - 2024

N2 - OBJECTIVES: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Although an acute SARS-CoV-2 infection mainly presents with respiratory illness, neurologic symptoms and sequelae are increasingly recognised in the long-term treatment of COVID-19 patients. The pathophysiology and the neuropathogenesis behind neurologic complications of COVID-19 remain poorly understood, but mounting evidence points to endothelial dysfunction either directly caused by viral infection or indirectly by inflammatory cytokines, followed by a local immune response that may include virus-specific T cells. However, the type and role of central nervous system-infiltrating T cells in COVID-19 are complex and not fully understood.METHODS: We analysed distinct anatomical brain regions of patients who had deceased as a result of COVID-19-associated pneumonia or complications thereof and performed T cell receptor Vβ repertoire sequencing. Clonotypes were analysed for SARS-CoV-2 association using public TCR repertoire data.RESULTS: Our descriptive study demonstrates that SARS-CoV-2-associated T cells are found in almost all brain areas of patients with fatal COVID-19 courses. The olfactory bulb, medulla and cerebellum were brain regions showing the most SARS-CoV-2 specific sequence patterns. Neuropathological workup demonstrated primary CD8+ T-cell infiltration with a perivascular infiltration pattern.CONCLUSION: Future research is needed to better define the relationship between T-cell infiltration and neurological symptoms and its long-term impact on patients' cognitive and mental health.

AB - OBJECTIVES: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Although an acute SARS-CoV-2 infection mainly presents with respiratory illness, neurologic symptoms and sequelae are increasingly recognised in the long-term treatment of COVID-19 patients. The pathophysiology and the neuropathogenesis behind neurologic complications of COVID-19 remain poorly understood, but mounting evidence points to endothelial dysfunction either directly caused by viral infection or indirectly by inflammatory cytokines, followed by a local immune response that may include virus-specific T cells. However, the type and role of central nervous system-infiltrating T cells in COVID-19 are complex and not fully understood.METHODS: We analysed distinct anatomical brain regions of patients who had deceased as a result of COVID-19-associated pneumonia or complications thereof and performed T cell receptor Vβ repertoire sequencing. Clonotypes were analysed for SARS-CoV-2 association using public TCR repertoire data.RESULTS: Our descriptive study demonstrates that SARS-CoV-2-associated T cells are found in almost all brain areas of patients with fatal COVID-19 courses. The olfactory bulb, medulla and cerebellum were brain regions showing the most SARS-CoV-2 specific sequence patterns. Neuropathological workup demonstrated primary CD8+ T-cell infiltration with a perivascular infiltration pattern.CONCLUSION: Future research is needed to better define the relationship between T-cell infiltration and neurological symptoms and its long-term impact on patients' cognitive and mental health.

U2 - 10.1002/cti2.1487

DO - 10.1002/cti2.1487

M3 - Short publication

C2 - 38304555

VL - 13

SP - e1487

JO - CLIN TRANSL IMMUNOL

JF - CLIN TRANSL IMMUNOL

SN - 2050-0068

IS - 2

ER -