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SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients

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SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients. / Heinrich, Fabian; Nentwich, Michael F; Bibiza-Freiwald, Eric; Nörz, Dominik; Roedl, Kevin; Christner, Martin; Hoffmann, Armin; Olearo, Flaminia; Kluge, Stefan; Aepfelbacher, Martin; Wichmann, Dominic; Lütgehetmann, Marc; Pfefferle, Susanne.

In: OPEN FORUM INFECT DI, Vol. 8, No. 11, ofab509, 11.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heinrich, F, Nentwich, MF, Bibiza-Freiwald, E, Nörz, D, Roedl, K, Christner, M, Hoffmann, A, Olearo, F, Kluge, S, Aepfelbacher, M, Wichmann, D, Lütgehetmann, M & Pfefferle, S 2021, 'SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients', OPEN FORUM INFECT DI, vol. 8, no. 11, ofab509. https://doi.org/10.1093/ofid/ofab509

APA

Heinrich, F., Nentwich, M. F., Bibiza-Freiwald, E., Nörz, D., Roedl, K., Christner, M., Hoffmann, A., Olearo, F., Kluge, S., Aepfelbacher, M., Wichmann, D., Lütgehetmann, M., & Pfefferle, S. (2021). SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients. OPEN FORUM INFECT DI, 8(11), [ofab509]. https://doi.org/10.1093/ofid/ofab509

Vancouver

Heinrich F, Nentwich MF, Bibiza-Freiwald E, Nörz D, Roedl K, Christner M et al. SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients. OPEN FORUM INFECT DI. 2021 Nov;8(11). ofab509. https://doi.org/10.1093/ofid/ofab509

Bibtex

@article{29c204bd10554241832e7d97666b8ef1,
title = "SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients",
abstract = "Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA loads in patient specimens may act as a clinical outcome predictor in critically ill patients with coronavirus disease 2019 (COVID-19).Methods: We evaluated the predictive value of viral RNA loads and courses in the blood compared with the upper and lower respiratory tract loads of critically ill COVID-19 patients. Daily specimen collection and viral RNA quantification by reverse transcription quantitative polymerase chain reaction were performed in all consecutive 170 COVID-19 patients between March 2020 and February 2021 during the entire intensive care unit (ICU) stay (4145 samples analyzed). Patients were grouped according to their 90-day outcome as survivors (n=100) or nonsurvivors (n=70).Results: In nonsurvivors, blood SARS-CoV-2 RNA loads were significantly higher at the time of admission to the ICU (P=.0009). Failure of blood RNA clearance was observed in 33/50 (66%) of the nonsurvivors compared with 12/64 (19%) survivors (P<.0001). As determined by multivariate analysis, taking sociodemographic and clinical parameters into account, blood SARS-CoV-2 RNA load represents a valid and independent predictor of outcome in critically ill COVID-19 patients (odds ratio [OR; log10], 0.23; 95% CI, 0.12-0.42; P<.0001), with a significantly higher effect for survival compared with respiratory tract SARS-CoV-2 RNA loads (OR [log10], 0.75; 95% CI, 0.66-0.85; P<.0001). Blood RNA loads exceeding 2.51×103 SARS-CoV-2 RNA copies/mL were found to indicate a 50% probability of death. Consistently, 29/33 (88%) nonsurvivors with failure of virus clearance exceeded this cutoff value constantly.Conclusions: Blood SARS-CoV-2 load is an important independent outcome predictor and should be further evaluated for treatment allocation and patient monitoring.",
author = "Fabian Heinrich and Nentwich, {Michael F} and Eric Bibiza-Freiwald and Dominik N{\"o}rz and Kevin Roedl and Martin Christner and Armin Hoffmann and Flaminia Olearo and Stefan Kluge and Martin Aepfelbacher and Dominic Wichmann and Marc L{\"u}tgehetmann and Susanne Pfefferle",
year = "2021",
month = nov,
doi = "10.1093/ofid/ofab509",
language = "English",
volume = "8",
journal = "OPEN FORUM INFECT DI",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients

AU - Heinrich, Fabian

AU - Nentwich, Michael F

AU - Bibiza-Freiwald, Eric

AU - Nörz, Dominik

AU - Roedl, Kevin

AU - Christner, Martin

AU - Hoffmann, Armin

AU - Olearo, Flaminia

AU - Kluge, Stefan

AU - Aepfelbacher, Martin

AU - Wichmann, Dominic

AU - Lütgehetmann, Marc

AU - Pfefferle, Susanne

PY - 2021/11

Y1 - 2021/11

N2 - Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA loads in patient specimens may act as a clinical outcome predictor in critically ill patients with coronavirus disease 2019 (COVID-19).Methods: We evaluated the predictive value of viral RNA loads and courses in the blood compared with the upper and lower respiratory tract loads of critically ill COVID-19 patients. Daily specimen collection and viral RNA quantification by reverse transcription quantitative polymerase chain reaction were performed in all consecutive 170 COVID-19 patients between March 2020 and February 2021 during the entire intensive care unit (ICU) stay (4145 samples analyzed). Patients were grouped according to their 90-day outcome as survivors (n=100) or nonsurvivors (n=70).Results: In nonsurvivors, blood SARS-CoV-2 RNA loads were significantly higher at the time of admission to the ICU (P=.0009). Failure of blood RNA clearance was observed in 33/50 (66%) of the nonsurvivors compared with 12/64 (19%) survivors (P<.0001). As determined by multivariate analysis, taking sociodemographic and clinical parameters into account, blood SARS-CoV-2 RNA load represents a valid and independent predictor of outcome in critically ill COVID-19 patients (odds ratio [OR; log10], 0.23; 95% CI, 0.12-0.42; P<.0001), with a significantly higher effect for survival compared with respiratory tract SARS-CoV-2 RNA loads (OR [log10], 0.75; 95% CI, 0.66-0.85; P<.0001). Blood RNA loads exceeding 2.51×103 SARS-CoV-2 RNA copies/mL were found to indicate a 50% probability of death. Consistently, 29/33 (88%) nonsurvivors with failure of virus clearance exceeded this cutoff value constantly.Conclusions: Blood SARS-CoV-2 load is an important independent outcome predictor and should be further evaluated for treatment allocation and patient monitoring.

AB - Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA loads in patient specimens may act as a clinical outcome predictor in critically ill patients with coronavirus disease 2019 (COVID-19).Methods: We evaluated the predictive value of viral RNA loads and courses in the blood compared with the upper and lower respiratory tract loads of critically ill COVID-19 patients. Daily specimen collection and viral RNA quantification by reverse transcription quantitative polymerase chain reaction were performed in all consecutive 170 COVID-19 patients between March 2020 and February 2021 during the entire intensive care unit (ICU) stay (4145 samples analyzed). Patients were grouped according to their 90-day outcome as survivors (n=100) or nonsurvivors (n=70).Results: In nonsurvivors, blood SARS-CoV-2 RNA loads were significantly higher at the time of admission to the ICU (P=.0009). Failure of blood RNA clearance was observed in 33/50 (66%) of the nonsurvivors compared with 12/64 (19%) survivors (P<.0001). As determined by multivariate analysis, taking sociodemographic and clinical parameters into account, blood SARS-CoV-2 RNA load represents a valid and independent predictor of outcome in critically ill COVID-19 patients (odds ratio [OR; log10], 0.23; 95% CI, 0.12-0.42; P<.0001), with a significantly higher effect for survival compared with respiratory tract SARS-CoV-2 RNA loads (OR [log10], 0.75; 95% CI, 0.66-0.85; P<.0001). Blood RNA loads exceeding 2.51×103 SARS-CoV-2 RNA copies/mL were found to indicate a 50% probability of death. Consistently, 29/33 (88%) nonsurvivors with failure of virus clearance exceeded this cutoff value constantly.Conclusions: Blood SARS-CoV-2 load is an important independent outcome predictor and should be further evaluated for treatment allocation and patient monitoring.

U2 - 10.1093/ofid/ofab509

DO - 10.1093/ofid/ofab509

M3 - SCORING: Journal article

C2 - 34796247

VL - 8

JO - OPEN FORUM INFECT DI

JF - OPEN FORUM INFECT DI

SN - 2328-8957

IS - 11

M1 - ofab509

ER -