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Safety and Efficacy of Excimer Laser Powered Lead Extractions in Obese Patients: A GALLERY Subgroup Analysis

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Safety and Efficacy of Excimer Laser Powered Lead Extractions in Obese Patients: A GALLERY Subgroup Analysis. / Schenker, Niklas; Chung, Da-Un; Burger, Heiko; Kaiser, Lukas; Osswald, Brigitte; Bärsch, Volker; Nägele, Herbert; Knaut, Michael; Reichenspurner, Hermann; Gessler, Nele; Willems, Stephan; Butter, Christian; Pecha, Simon; Hakmi, Samer.

In: J CLIN MED, Vol. 12, No. 12, 4096, 16.06.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schenker, N, Chung, D-U, Burger, H, Kaiser, L, Osswald, B, Bärsch, V, Nägele, H, Knaut, M, Reichenspurner, H, Gessler, N, Willems, S, Butter, C, Pecha, S & Hakmi, S 2023, 'Safety and Efficacy of Excimer Laser Powered Lead Extractions in Obese Patients: A GALLERY Subgroup Analysis', J CLIN MED, vol. 12, no. 12, 4096. https://doi.org/10.3390/jcm12124096

APA

Schenker, N., Chung, D-U., Burger, H., Kaiser, L., Osswald, B., Bärsch, V., Nägele, H., Knaut, M., Reichenspurner, H., Gessler, N., Willems, S., Butter, C., Pecha, S., & Hakmi, S. (2023). Safety and Efficacy of Excimer Laser Powered Lead Extractions in Obese Patients: A GALLERY Subgroup Analysis. J CLIN MED, 12(12), [4096]. https://doi.org/10.3390/jcm12124096

Vancouver

Schenker N, Chung D-U, Burger H, Kaiser L, Osswald B, Bärsch V et al. Safety and Efficacy of Excimer Laser Powered Lead Extractions in Obese Patients: A GALLERY Subgroup Analysis. J CLIN MED. 2023 Jun 16;12(12). 4096. https://doi.org/10.3390/jcm12124096

Bibtex

@article{2ff6e6cf4e7a45c686bdaf228a88913d,
title = "Safety and Efficacy of Excimer Laser Powered Lead Extractions in Obese Patients: A GALLERY Subgroup Analysis",
abstract = "BACKGROUND: The incidence of cardiac implantable electronic device (CIED)-related complications, as well as the prevalence of obesity, is rising worldwide. Transvenous laser lead extraction (LLE) has grown into a crucial therapeutic option for patients with CIED-related complications but the impact of obesity on LLE is not well understood.METHODS AND RESULTS: All patients (n = 2524) from the GermAn Laser Lead Extraction RegistrY (GALLERY) were stratified into five groups according to their body mass index (BMI, <18.5; 18.5-24.9; 25-29.9; 30-34.9; ≥35 kg/m2). Patients with a BMI ≥ 35.0 kg/m2 had the highest prevalence of arterial hypertension (84.2%, p < 0.001), chronic kidney disease (36.8%, p = 0.020) and diabetes mellitus (51.1%, p < 0.001). The rates for procedural minor (p = 0.684) and major complications (p = 0.498), as well as procedural success (p = 0.437), procedure-related (p = 0.533) and all-cause mortality (p = 0.333) were not different between groups. In obese patients (BMI ≥ 30 kg/m2), lead age ≥10 years was identified as a predictor of procedural failure (OR: 2.99; 95% CI: 1.06-8.45; p = 0.038). Lead age ≥10 years (OR: 3.25; 95% CI: 1,31-8.10; p = 0.011) and abandoned leads (OR: 3.08; 95% CI: 1.03-9.22; p = 0.044) were predictors of procedural complications, while patient age ≥75 years seemed protective (OR: 0.27; 95% CI: 0.08-0.93; p = 0.039). Systemic infection was the only predictor for all-cause mortality (OR: 17.68; 95% CI: 4.03-77.49; p < 0.001).CONCLUSIONS: LLE in obese patients is as safe and effective as in other weight classes, if performed in experienced high-volume centers. Systemic infection remains the main cause of in-hospital mortality in obese patients.",
author = "Niklas Schenker and Da-Un Chung and Heiko Burger and Lukas Kaiser and Brigitte Osswald and Volker B{\"a}rsch and Herbert N{\"a}gele and Michael Knaut and Hermann Reichenspurner and Nele Gessler and Stephan Willems and Christian Butter and Simon Pecha and Samer Hakmi",
year = "2023",
month = jun,
day = "16",
doi = "10.3390/jcm12124096",
language = "English",
volume = "12",
journal = "J CLIN MED",
issn = "2077-0383",
publisher = "MDPI AG",
number = "12",

}

RIS

TY - JOUR

T1 - Safety and Efficacy of Excimer Laser Powered Lead Extractions in Obese Patients: A GALLERY Subgroup Analysis

AU - Schenker, Niklas

AU - Chung, Da-Un

AU - Burger, Heiko

AU - Kaiser, Lukas

AU - Osswald, Brigitte

AU - Bärsch, Volker

AU - Nägele, Herbert

AU - Knaut, Michael

AU - Reichenspurner, Hermann

AU - Gessler, Nele

AU - Willems, Stephan

AU - Butter, Christian

AU - Pecha, Simon

AU - Hakmi, Samer

PY - 2023/6/16

Y1 - 2023/6/16

N2 - BACKGROUND: The incidence of cardiac implantable electronic device (CIED)-related complications, as well as the prevalence of obesity, is rising worldwide. Transvenous laser lead extraction (LLE) has grown into a crucial therapeutic option for patients with CIED-related complications but the impact of obesity on LLE is not well understood.METHODS AND RESULTS: All patients (n = 2524) from the GermAn Laser Lead Extraction RegistrY (GALLERY) were stratified into five groups according to their body mass index (BMI, <18.5; 18.5-24.9; 25-29.9; 30-34.9; ≥35 kg/m2). Patients with a BMI ≥ 35.0 kg/m2 had the highest prevalence of arterial hypertension (84.2%, p < 0.001), chronic kidney disease (36.8%, p = 0.020) and diabetes mellitus (51.1%, p < 0.001). The rates for procedural minor (p = 0.684) and major complications (p = 0.498), as well as procedural success (p = 0.437), procedure-related (p = 0.533) and all-cause mortality (p = 0.333) were not different between groups. In obese patients (BMI ≥ 30 kg/m2), lead age ≥10 years was identified as a predictor of procedural failure (OR: 2.99; 95% CI: 1.06-8.45; p = 0.038). Lead age ≥10 years (OR: 3.25; 95% CI: 1,31-8.10; p = 0.011) and abandoned leads (OR: 3.08; 95% CI: 1.03-9.22; p = 0.044) were predictors of procedural complications, while patient age ≥75 years seemed protective (OR: 0.27; 95% CI: 0.08-0.93; p = 0.039). Systemic infection was the only predictor for all-cause mortality (OR: 17.68; 95% CI: 4.03-77.49; p < 0.001).CONCLUSIONS: LLE in obese patients is as safe and effective as in other weight classes, if performed in experienced high-volume centers. Systemic infection remains the main cause of in-hospital mortality in obese patients.

AB - BACKGROUND: The incidence of cardiac implantable electronic device (CIED)-related complications, as well as the prevalence of obesity, is rising worldwide. Transvenous laser lead extraction (LLE) has grown into a crucial therapeutic option for patients with CIED-related complications but the impact of obesity on LLE is not well understood.METHODS AND RESULTS: All patients (n = 2524) from the GermAn Laser Lead Extraction RegistrY (GALLERY) were stratified into five groups according to their body mass index (BMI, <18.5; 18.5-24.9; 25-29.9; 30-34.9; ≥35 kg/m2). Patients with a BMI ≥ 35.0 kg/m2 had the highest prevalence of arterial hypertension (84.2%, p < 0.001), chronic kidney disease (36.8%, p = 0.020) and diabetes mellitus (51.1%, p < 0.001). The rates for procedural minor (p = 0.684) and major complications (p = 0.498), as well as procedural success (p = 0.437), procedure-related (p = 0.533) and all-cause mortality (p = 0.333) were not different between groups. In obese patients (BMI ≥ 30 kg/m2), lead age ≥10 years was identified as a predictor of procedural failure (OR: 2.99; 95% CI: 1.06-8.45; p = 0.038). Lead age ≥10 years (OR: 3.25; 95% CI: 1,31-8.10; p = 0.011) and abandoned leads (OR: 3.08; 95% CI: 1.03-9.22; p = 0.044) were predictors of procedural complications, while patient age ≥75 years seemed protective (OR: 0.27; 95% CI: 0.08-0.93; p = 0.039). Systemic infection was the only predictor for all-cause mortality (OR: 17.68; 95% CI: 4.03-77.49; p < 0.001).CONCLUSIONS: LLE in obese patients is as safe and effective as in other weight classes, if performed in experienced high-volume centers. Systemic infection remains the main cause of in-hospital mortality in obese patients.

U2 - 10.3390/jcm12124096

DO - 10.3390/jcm12124096

M3 - SCORING: Journal article

C2 - 37373789

VL - 12

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 12

M1 - 4096

ER -