Safety and efficacy of belantamab mafodotin with pembrolizumab in patients with relapsed or refractory multiple myeloma
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Safety and efficacy of belantamab mafodotin with pembrolizumab in patients with relapsed or refractory multiple myeloma. / Suvannasankha, Attaya; Bahlis, Nizar; Trudel, Suzanne; Weisel, Katja; Koenecke, Christian; Oriol, Albert; Voorhees, Peter M; Alonso, Aranzazu A; Callander, Natalie S; Mateos, María-Victoria; Reddy, Nishitha; Hakim, Shawn; LaMacchia, John; Patel, Nashita; Williams, Danaé; Jewell, Roxanne C; Zhou, Xiangdong; Gupta, Ira; Opalinska, Joanna; Nooka, Ajay K.
In: CANCER-AM CANCER SOC, Vol. 130, No. 15, 01.08.2024, p. 2629-2641.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Safety and efficacy of belantamab mafodotin with pembrolizumab in patients with relapsed or refractory multiple myeloma
AU - Suvannasankha, Attaya
AU - Bahlis, Nizar
AU - Trudel, Suzanne
AU - Weisel, Katja
AU - Koenecke, Christian
AU - Oriol, Albert
AU - Voorhees, Peter M
AU - Alonso, Aranzazu A
AU - Callander, Natalie S
AU - Mateos, María-Victoria
AU - Reddy, Nishitha
AU - Hakim, Shawn
AU - LaMacchia, John
AU - Patel, Nashita
AU - Williams, Danaé
AU - Jewell, Roxanne C
AU - Zhou, Xiangdong
AU - Gupta, Ira
AU - Opalinska, Joanna
AU - Nooka, Ajay K
N1 - © 2024 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.
PY - 2024/8/1
Y1 - 2024/8/1
N2 - BACKGROUND: Belantamab mafodotin (belamaf) has shown promising antimyeloma activity in relapsed or refractory multiple myeloma (RRMM) as a single agent. It was hypothesized that its multimodal activity may be enhanced by programmed cell death protein 1 pathway inhibition and activation of T cell-mediated antitumor responses. This study investigated the efficacy and safety of belamaf with pembrolizumab in patients with RRMM.METHODS: DREAMM-4 (NCT03848845) was an open-label, single-arm, phase 1/2 study divided into dose-escalation (part 1) and dose-expansion (part 2) phases. Patients were ≥18 years old with ≥3 prior lines of therapy including a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 agent. Patients received belamaf (2.5 or 3.4 mg/kg, part 1; 2.5 mg/kg, part 2) and 200 mg pembrolizumab for ≤35 cycles.RESULTS: Of 41 enrolled patients, 34 (n = 6 part 1, n = 28 part 2) who received 2.5 mg/kg belamaf plus pembrolizumab were included in this final analysis. Sixteen patients (47%) achieved an overall response. Minimal residual disease negativity was achieved in three of 10 patients who had very good partial response or better. Five of eight patients who had prior anti-B-cell maturation antigen therapy achieved partial response or better, including two who had B-cell maturation antigen-refractory disease. Common grade ≥3 adverse events were keratopathy (38%) and thrombocytopenia (29%). Despite belamaf-related ocular events, quality-of-life measures remained stable over time. No new safety signals were observed.CONCLUSIONS: The results of DREAMM-4 demonstrated clinical activity and a favorable safety profile of belamaf plus pembrolizumab in patients with RRMM. This trial is registered at www.CLINICALTRIALS: gov as NCT03848845.
AB - BACKGROUND: Belantamab mafodotin (belamaf) has shown promising antimyeloma activity in relapsed or refractory multiple myeloma (RRMM) as a single agent. It was hypothesized that its multimodal activity may be enhanced by programmed cell death protein 1 pathway inhibition and activation of T cell-mediated antitumor responses. This study investigated the efficacy and safety of belamaf with pembrolizumab in patients with RRMM.METHODS: DREAMM-4 (NCT03848845) was an open-label, single-arm, phase 1/2 study divided into dose-escalation (part 1) and dose-expansion (part 2) phases. Patients were ≥18 years old with ≥3 prior lines of therapy including a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 agent. Patients received belamaf (2.5 or 3.4 mg/kg, part 1; 2.5 mg/kg, part 2) and 200 mg pembrolizumab for ≤35 cycles.RESULTS: Of 41 enrolled patients, 34 (n = 6 part 1, n = 28 part 2) who received 2.5 mg/kg belamaf plus pembrolizumab were included in this final analysis. Sixteen patients (47%) achieved an overall response. Minimal residual disease negativity was achieved in three of 10 patients who had very good partial response or better. Five of eight patients who had prior anti-B-cell maturation antigen therapy achieved partial response or better, including two who had B-cell maturation antigen-refractory disease. Common grade ≥3 adverse events were keratopathy (38%) and thrombocytopenia (29%). Despite belamaf-related ocular events, quality-of-life measures remained stable over time. No new safety signals were observed.CONCLUSIONS: The results of DREAMM-4 demonstrated clinical activity and a favorable safety profile of belamaf plus pembrolizumab in patients with RRMM. This trial is registered at www.CLINICALTRIALS: gov as NCT03848845.
U2 - 10.1002/cncr.35319
DO - 10.1002/cncr.35319
M3 - SCORING: Journal article
C2 - 38630908
VL - 130
SP - 2629
EP - 2641
JO - CANCER-AM CANCER SOC
JF - CANCER-AM CANCER SOC
SN - 0008-543X
IS - 15
ER -