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S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis

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S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis. / Németh, Julia; Stein, Ilan; Haag, Daniel; Riehl, Astrid; Longerich, Thomas; Horwitz, Elad; Breuhahn, Kai; Gebhardt, Christoffer; Schirmacher, Peter; Hahn, Meinhard; Ben-Neriah, Yinon; Pikarsky, Eli; Angel, Peter; Hess, Jochen.

In: HEPATOLOGY, Vol. 50, No. 4, 10.2009, p. 1251-62.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Németh, J, Stein, I, Haag, D, Riehl, A, Longerich, T, Horwitz, E, Breuhahn, K, Gebhardt, C, Schirmacher, P, Hahn, M, Ben-Neriah, Y, Pikarsky, E, Angel, P & Hess, J 2009, 'S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis', HEPATOLOGY, vol. 50, no. 4, pp. 1251-62. https://doi.org/10.1002/hep.23099

APA

Németh, J., Stein, I., Haag, D., Riehl, A., Longerich, T., Horwitz, E., Breuhahn, K., Gebhardt, C., Schirmacher, P., Hahn, M., Ben-Neriah, Y., Pikarsky, E., Angel, P., & Hess, J. (2009). S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis. HEPATOLOGY, 50(4), 1251-62. https://doi.org/10.1002/hep.23099

Vancouver

Németh J, Stein I, Haag D, Riehl A, Longerich T, Horwitz E et al. S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis. HEPATOLOGY. 2009 Oct;50(4):1251-62. https://doi.org/10.1002/hep.23099

Bibtex

@article{e312c1bac7294b4ca9dd6b99ad8fee13,
title = "S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis",
abstract = "UNLABELLED: The nuclear factor-kappaB (NF-kappaB) signaling pathway has been recently shown to participate in inflammation-induced cancer progression. Here, we describe a detailed analysis of the NF-kappaB-dependent gene regulatory network in the well-established Mdr2 knockout mouse model of inflammation-associated liver carcinogenesis. Expression profiling of NF-kappaB-deficient and NF-kappaB-proficient hepatocellular carcinoma (HCC) revealed a comprehensive list of known and novel putative NF-kappaB target genes, including S100a8 and S100a9. We detected increased co-expression of S100A8 and S100A9 proteins in mouse HCC cells, in human HCC tissue, and in the HCC cell line Hep3B on ectopic RelA expression. Finally, we found a synergistic function for S100A8 and S100A9 in Hep3B cells resulting in a significant induction of reactive oxygen species (ROS), accompanied by enhanced cell survival.CONCLUSION: We identified S100A8 and S100A9 as novel NF-kappaB target genes in HCC cells during inflammation-associated liver carcinogenesis and provide experimental evidence that increased co-expression of both proteins supports malignant progression by activation of ROS-dependent signaling pathways and protection from cell death.",
keywords = "ATP Binding Cassette Transporter, Sub-Family B, Animals, Apoptosis, Calgranulin A, Calgranulin B, Carcinoma, Hepatocellular, Cell Line, Tumor, Disease Models, Animal, Humans, Liver Neoplasms, Mice, Mice, Knockout, Mice, Transgenic, NF-kappa B, Reactive Oxygen Species, Signal Transduction, Journal Article, Research Support, Non-U.S. Gov't",
author = "Julia N{\'e}meth and Ilan Stein and Daniel Haag and Astrid Riehl and Thomas Longerich and Elad Horwitz and Kai Breuhahn and Christoffer Gebhardt and Peter Schirmacher and Meinhard Hahn and Yinon Ben-Neriah and Eli Pikarsky and Peter Angel and Jochen Hess",
year = "2009",
month = oct,
doi = "10.1002/hep.23099",
language = "English",
volume = "50",
pages = "1251--62",
journal = "HEPATOLOGY",
issn = "0270-9139",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis

AU - Németh, Julia

AU - Stein, Ilan

AU - Haag, Daniel

AU - Riehl, Astrid

AU - Longerich, Thomas

AU - Horwitz, Elad

AU - Breuhahn, Kai

AU - Gebhardt, Christoffer

AU - Schirmacher, Peter

AU - Hahn, Meinhard

AU - Ben-Neriah, Yinon

AU - Pikarsky, Eli

AU - Angel, Peter

AU - Hess, Jochen

PY - 2009/10

Y1 - 2009/10

N2 - UNLABELLED: The nuclear factor-kappaB (NF-kappaB) signaling pathway has been recently shown to participate in inflammation-induced cancer progression. Here, we describe a detailed analysis of the NF-kappaB-dependent gene regulatory network in the well-established Mdr2 knockout mouse model of inflammation-associated liver carcinogenesis. Expression profiling of NF-kappaB-deficient and NF-kappaB-proficient hepatocellular carcinoma (HCC) revealed a comprehensive list of known and novel putative NF-kappaB target genes, including S100a8 and S100a9. We detected increased co-expression of S100A8 and S100A9 proteins in mouse HCC cells, in human HCC tissue, and in the HCC cell line Hep3B on ectopic RelA expression. Finally, we found a synergistic function for S100A8 and S100A9 in Hep3B cells resulting in a significant induction of reactive oxygen species (ROS), accompanied by enhanced cell survival.CONCLUSION: We identified S100A8 and S100A9 as novel NF-kappaB target genes in HCC cells during inflammation-associated liver carcinogenesis and provide experimental evidence that increased co-expression of both proteins supports malignant progression by activation of ROS-dependent signaling pathways and protection from cell death.

AB - UNLABELLED: The nuclear factor-kappaB (NF-kappaB) signaling pathway has been recently shown to participate in inflammation-induced cancer progression. Here, we describe a detailed analysis of the NF-kappaB-dependent gene regulatory network in the well-established Mdr2 knockout mouse model of inflammation-associated liver carcinogenesis. Expression profiling of NF-kappaB-deficient and NF-kappaB-proficient hepatocellular carcinoma (HCC) revealed a comprehensive list of known and novel putative NF-kappaB target genes, including S100a8 and S100a9. We detected increased co-expression of S100A8 and S100A9 proteins in mouse HCC cells, in human HCC tissue, and in the HCC cell line Hep3B on ectopic RelA expression. Finally, we found a synergistic function for S100A8 and S100A9 in Hep3B cells resulting in a significant induction of reactive oxygen species (ROS), accompanied by enhanced cell survival.CONCLUSION: We identified S100A8 and S100A9 as novel NF-kappaB target genes in HCC cells during inflammation-associated liver carcinogenesis and provide experimental evidence that increased co-expression of both proteins supports malignant progression by activation of ROS-dependent signaling pathways and protection from cell death.

KW - ATP Binding Cassette Transporter, Sub-Family B

KW - Animals

KW - Apoptosis

KW - Calgranulin A

KW - Calgranulin B

KW - Carcinoma, Hepatocellular

KW - Cell Line, Tumor

KW - Disease Models, Animal

KW - Humans

KW - Liver Neoplasms

KW - Mice

KW - Mice, Knockout

KW - Mice, Transgenic

KW - NF-kappa B

KW - Reactive Oxygen Species

KW - Signal Transduction

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/hep.23099

DO - 10.1002/hep.23099

M3 - SCORING: Journal article

C2 - 19670424

VL - 50

SP - 1251

EP - 1262

JO - HEPATOLOGY

JF - HEPATOLOGY

SN - 0270-9139

IS - 4

ER -