S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection.
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S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection. / Andresen, Ellen; Lange, Christoph; Strodthoff, Daniela; Goldmann, Torsten; Fischer, Nicole; Sahly, Hany; Branscheid, Detlev; Heine, Holger.
In: BMC PULM MED, Vol. 11, 2011, p. 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection.
AU - Andresen, Ellen
AU - Lange, Christoph
AU - Strodthoff, Daniela
AU - Goldmann, Torsten
AU - Fischer, Nicole
AU - Sahly, Hany
AU - Branscheid, Detlev
AU - Heine, Holger
PY - 2011
Y1 - 2011
N2 - Progressive airway inflammation and susceptibility to the airway colonisation and infection are characteristic for the pathophysiology of chronic obstructive pulmonary disease (COPD). Antimicrobial peptides (AMPs) are central to the function of the innate host immune response against microbial pathogens and are regulators of inflammation and immunity. S100A7/psoriasin, a recently described AMP, is an essential component of the human epithelia against invading pathogens and acts as an effector molecule of the host innate defence in the skin. We hypothesized that S100A7/psoriasin is involved in the airway mucosal immunity and differently regulated and expressed in the lung during progression of COPD.
AB - Progressive airway inflammation and susceptibility to the airway colonisation and infection are characteristic for the pathophysiology of chronic obstructive pulmonary disease (COPD). Antimicrobial peptides (AMPs) are central to the function of the innate host immune response against microbial pathogens and are regulators of inflammation and immunity. S100A7/psoriasin, a recently described AMP, is an essential component of the human epithelia against invading pathogens and acts as an effector molecule of the host innate defence in the skin. We hypothesized that S100A7/psoriasin is involved in the airway mucosal immunity and differently regulated and expressed in the lung during progression of COPD.
KW - Adult
KW - Biopsy
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Case-Control Studies
KW - RNA, Messenger/metabolism
KW - Bronchi/metabolism/microbiology/pathology
KW - Bronchoalveolar Lavage Fluid/cytology
KW - Immunity, Innate/physiology
KW - Lung/metabolism/microbiology/pathology
KW - Pulmonary Disease, Chronic Obstructive/immunology/metabolism/pathology
KW - S100 Proteins/metabolism
KW - Staphylococcal Infections/immunology/metabolism/pathology
KW - Staphylococcus aureus/immunology/isolation & purification
KW - Adult
KW - Biopsy
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Case-Control Studies
KW - RNA, Messenger/metabolism
KW - Bronchi/metabolism/microbiology/pathology
KW - Bronchoalveolar Lavage Fluid/cytology
KW - Immunity, Innate/physiology
KW - Lung/metabolism/microbiology/pathology
KW - Pulmonary Disease, Chronic Obstructive/immunology/metabolism/pathology
KW - S100 Proteins/metabolism
KW - Staphylococcal Infections/immunology/metabolism/pathology
KW - Staphylococcus aureus/immunology/isolation & purification
U2 - 10.1186/1471-2466-11-10
DO - 10.1186/1471-2466-11-10
M3 - SCORING: Journal article
VL - 11
SP - 10
JO - BMC PULM MED
JF - BMC PULM MED
SN - 1471-2466
ER -
