Research ExplorerPublicationsrs2735383, located at a microRNA binding site in the 3'UTR o...

rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk

Standard

rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk. / Liu, Jingjing; Lončar, Ivona; Collée, J Margriet; Bolla, Manjeet K; Dennis, Joe; Michailidou, Kyriaki; Wang, Qin; Andrulis, Irene L; Barile, Monica; Behrens, Sabine; Benitez, Javier; Blomqvist, Carl; Boeckx, Bram; Bogdanova, Natalia V; Bojesen, Stig E; Brauch, Hiltrud; Brennan, Paul; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Chang-Claude, Jenny; Chen, Shou-Tung; Chenevix-Trench, Georgia; Cheng, Yu-Ching; Choi, Ji-Yeob; Couch, Fergus J; Cox, Angela; Cross, Simon S; Cuk, Katarina; Czene, Kamila; Dörk, Thilo; Dos-Santos-Silva, Isabel; Fasching, Peter A; Figueroa, Jonine; Flyger, Henrik; García-Closas, Montserrat; Giles, Graham; Glendon, Gord; Goldberg, Mark S; González-Neira, Anna; Guénel, Pascal; Haiman, Christopher A; Hamann, Ute; Hart, Steven N; Hartman, Mikael; Hatse, Sigrid; Hopper, John L; Ito, Hidemi; Jakubowska, Anna; Kabisch, Maria; Kang, Daehee; Kosma, Veli-Matti; Kristensen, Vessela N; Le Marchand, Loic; Lee, Eunjung; Li, Jingmei; Lophatananon, Artitaya; Jan Lubinski; Mannermaa, Arto; Matsuo, Keitaro; Milne, Roger L; Neuhausen, Susan L; Nevanlinna, Heli; Orr, Nick; Perez, Jose Ignacio Arias; Peto, Julian; Putti, Thomas Choudary; Pylkäs, Katri; Radice, Paolo; Sangrajrang, Suleeporn; Sawyer, Elinor J; Schmidt, Marjanka K; Schneeweiss, Andreas; Shen, Chen-Yang; Shrubsole, Martha J; Shu, Xiao-Ou; Simard, Jacques; Southey, Melissa C; Swerdlow, Anthony; Teo, Soo-Hwang; Tessier, Daniel C; Thanasitthichai, Somchai; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; Tseng, Chiu-Chen; Vachon, Celine; Winqvist, Robert; Wu, Anna H; Yannoukakos, Drakoulis; Zheng, Wei; Hall, Per; Dunning, Alison M; Easton, Douglas F; Hooning, Maartje J; Ouweland, Ans M W van der; Martens, John W M; Hollestelle, Antoinette; NBCS Collaborators.

In: SCI REP-UK, Vol. 6, 15.11.2016, p. 36874.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Liu, J, Lončar, I, Collée, JM, Bolla, MK, Dennis, J, Michailidou, K, Wang, Q, Andrulis, IL, Barile, M, Behrens, S, Benitez, J, Blomqvist, C, Boeckx, B, Bogdanova, NV, Bojesen, SE, Brauch, H, Brennan, P, Brenner, H, Broeks, A, Burwinkel, B, Chang-Claude, J, Chen, S-T, Chenevix-Trench, G, Cheng, Y-C, Choi, J-Y, Couch, FJ, Cox, A, Cross, SS, Cuk, K, Czene, K, Dörk, T, Dos-Santos-Silva, I, Fasching, PA, Figueroa, J, Flyger, H, García-Closas, M, Giles, G, Glendon, G, Goldberg, MS, González-Neira, A, Guénel, P, Haiman, CA, Hamann, U, Hart, SN, Hartman, M, Hatse, S, Hopper, JL, Ito, H, Jakubowska, A, Kabisch, M, Kang, D, Kosma, V-M, Kristensen, VN, Le Marchand, L, Lee, E, Li, J, Lophatananon, A, Jan Lubinski, Mannermaa, A, Matsuo, K, Milne, RL, Neuhausen, SL, Nevanlinna, H, Orr, N, Perez, JIA, Peto, J, Putti, TC, Pylkäs, K, Radice, P, Sangrajrang, S, Sawyer, EJ, Schmidt, MK, Schneeweiss, A, Shen, C-Y, Shrubsole, MJ, Shu, X-O, Simard, J, Southey, MC, Swerdlow, A, Teo, S-H, Tessier, DC, Thanasitthichai, S, Tomlinson, I, Torres, D, Truong, T, Tseng, C-C, Vachon, C, Winqvist, R, Wu, AH, Yannoukakos, D, Zheng, W, Hall, P, Dunning, AM, Easton, DF, Hooning, MJ, Ouweland, AMWVD, Martens, JWM, Hollestelle, A & NBCS Collaborators 2016, 'rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk', SCI REP-UK, vol. 6, pp. 36874. https://doi.org/10.1038/srep36874

APA

Liu, J., Lončar, I., Collée, J. M., Bolla, M. K., Dennis, J., Michailidou, K., Wang, Q., Andrulis, I. L., Barile, M., Behrens, S., Benitez, J., Blomqvist, C., Boeckx, B., Bogdanova, N. V., Bojesen, S. E., Brauch, H., Brennan, P., Brenner, H., Broeks, A., ... NBCS Collaborators (2016). rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk. SCI REP-UK, 6, 36874. https://doi.org/10.1038/srep36874

Vancouver

Liu J, Lončar I, Collée JM, Bolla MK, Dennis J, Michailidou K et al. rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk. SCI REP-UK. 2016 Nov 15;6:36874. https://doi.org/10.1038/srep36874

Bibtex

@article{f87abbdb7e0741ea9ae64cc4724a402b,
title = "rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk",
abstract = "NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r(2) > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.",
keywords = "Journal Article",
author = "Jingjing Liu and Ivona Lon{\v c}ar and Coll{\'e}e, {J Margriet} and Bolla, {Manjeet K} and Joe Dennis and Kyriaki Michailidou and Qin Wang and Andrulis, {Irene L} and Monica Barile and Sabine Behrens and Javier Benitez and Carl Blomqvist and Bram Boeckx and Bogdanova, {Natalia V} and Bojesen, {Stig E} and Hiltrud Brauch and Paul Brennan and Hermann Brenner and Annegien Broeks and Barbara Burwinkel and Jenny Chang-Claude and Shou-Tung Chen and Georgia Chenevix-Trench and Yu-Ching Cheng and Ji-Yeob Choi and Couch, {Fergus J} and Angela Cox and Cross, {Simon S} and Katarina Cuk and Kamila Czene and Thilo D{\"o}rk and Isabel Dos-Santos-Silva and Fasching, {Peter A} and Jonine Figueroa and Henrik Flyger and Montserrat Garc{\'i}a-Closas and Graham Giles and Gord Glendon and Goldberg, {Mark S} and Anna Gonz{\'a}lez-Neira and Pascal Gu{\'e}nel and Haiman, {Christopher A} and Ute Hamann and Hart, {Steven N} and Mikael Hartman and Sigrid Hatse and Hopper, {John L} and Hidemi Ito and Anna Jakubowska and Maria Kabisch and Daehee Kang and Veli-Matti Kosma and Kristensen, {Vessela N} and {Le Marchand}, Loic and Eunjung Lee and Jingmei Li and Artitaya Lophatananon and {Jan Lubinski} and Arto Mannermaa and Keitaro Matsuo and Milne, {Roger L} and Neuhausen, {Susan L} and Heli Nevanlinna and Nick Orr and Perez, {Jose Ignacio Arias} and Julian Peto and Putti, {Thomas Choudary} and Katri Pylk{\"a}s and Paolo Radice and Suleeporn Sangrajrang and Sawyer, {Elinor J} and Schmidt, {Marjanka K} and Andreas Schneeweiss and Chen-Yang Shen and Shrubsole, {Martha J} and Xiao-Ou Shu and Jacques Simard and Southey, {Melissa C} and Anthony Swerdlow and Soo-Hwang Teo and Tessier, {Daniel C} and Somchai Thanasitthichai and Ian Tomlinson and Diana Torres and Th{\'e}r{\`e}se Truong and Chiu-Chen Tseng and Celine Vachon and Robert Winqvist and Wu, {Anna H} and Drakoulis Yannoukakos and Wei Zheng and Per Hall and Dunning, {Alison M} and Easton, {Douglas F} and Hooning, {Maartje J} and Ouweland, {Ans M W van der} and Martens, {John W M} and Antoinette Hollestelle and {NBCS Collaborators}",
year = "2016",
month = nov,
day = "15",
doi = "10.1038/srep36874",
language = "English",
volume = "6",
pages = "36874",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk

AU - Liu, Jingjing

AU - Lončar, Ivona

AU - Collée, J Margriet

AU - Bolla, Manjeet K

AU - Dennis, Joe

AU - Michailidou, Kyriaki

AU - Wang, Qin

AU - Andrulis, Irene L

AU - Barile, Monica

AU - Behrens, Sabine

AU - Benitez, Javier

AU - Blomqvist, Carl

AU - Boeckx, Bram

AU - Bogdanova, Natalia V

AU - Bojesen, Stig E

AU - Brauch, Hiltrud

AU - Brennan, Paul

AU - Brenner, Hermann

AU - Broeks, Annegien

AU - Burwinkel, Barbara

AU - Chang-Claude, Jenny

AU - Chen, Shou-Tung

AU - Chenevix-Trench, Georgia

AU - Cheng, Yu-Ching

AU - Choi, Ji-Yeob

AU - Couch, Fergus J

AU - Cox, Angela

AU - Cross, Simon S

AU - Cuk, Katarina

AU - Czene, Kamila

AU - Dörk, Thilo

AU - Dos-Santos-Silva, Isabel

AU - Fasching, Peter A

AU - Figueroa, Jonine

AU - Flyger, Henrik

AU - García-Closas, Montserrat

AU - Giles, Graham

AU - Glendon, Gord

AU - Goldberg, Mark S

AU - González-Neira, Anna

AU - Guénel, Pascal

AU - Haiman, Christopher A

AU - Hamann, Ute

AU - Hart, Steven N

AU - Hartman, Mikael

AU - Hatse, Sigrid

AU - Hopper, John L

AU - Ito, Hidemi

AU - Jakubowska, Anna

AU - Kabisch, Maria

AU - Kang, Daehee

AU - Kosma, Veli-Matti

AU - Kristensen, Vessela N

AU - Le Marchand, Loic

AU - Lee, Eunjung

AU - Li, Jingmei

AU - Lophatananon, Artitaya

AU - Jan Lubinski, null

AU - Mannermaa, Arto

AU - Matsuo, Keitaro

AU - Milne, Roger L

AU - Neuhausen, Susan L

AU - Nevanlinna, Heli

AU - Orr, Nick

AU - Perez, Jose Ignacio Arias

AU - Peto, Julian

AU - Putti, Thomas Choudary

AU - Pylkäs, Katri

AU - Radice, Paolo

AU - Sangrajrang, Suleeporn

AU - Sawyer, Elinor J

AU - Schmidt, Marjanka K

AU - Schneeweiss, Andreas

AU - Shen, Chen-Yang

AU - Shrubsole, Martha J

AU - Shu, Xiao-Ou

AU - Simard, Jacques

AU - Southey, Melissa C

AU - Swerdlow, Anthony

AU - Teo, Soo-Hwang

AU - Tessier, Daniel C

AU - Thanasitthichai, Somchai

AU - Tomlinson, Ian

AU - Torres, Diana

AU - Truong, Thérèse

AU - Tseng, Chiu-Chen

AU - Vachon, Celine

AU - Winqvist, Robert

AU - Wu, Anna H

AU - Yannoukakos, Drakoulis

AU - Zheng, Wei

AU - Hall, Per

AU - Dunning, Alison M

AU - Easton, Douglas F

AU - Hooning, Maartje J

AU - Ouweland, Ans M W van der

AU - Martens, John W M

AU - Hollestelle, Antoinette

AU - NBCS Collaborators

PY - 2016/11/15

Y1 - 2016/11/15

N2 - NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r(2) > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.

AB - NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r(2) > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.

KW - Journal Article

U2 - 10.1038/srep36874

DO - 10.1038/srep36874

M3 - SCORING: Journal article

C2 - 27845421

VL - 6

SP - 36874

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -