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Roles of the Chr.9p21.3 Locus in Regulating Inflammation and Implications for Anti-Inflammatory Drug Target Identification

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Roles of the Chr.9p21.3 Locus in Regulating Inflammation and Implications for Anti-Inflammatory Drug Target Identification. / Aarabi, Ghazal; Zeller, Tanja; Heydecke, Guido; Munz, Matthias; Schäfer, Arne; Seedorf, Udo.

In: FRONT CARDIOVASC MED, Vol. 5, No. 47, 01.05.2018.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Aarabi, G, Zeller, T, Heydecke, G, Munz, M, Schäfer, A & Seedorf, U 2018, 'Roles of the Chr.9p21.3 Locus in Regulating Inflammation and Implications for Anti-Inflammatory Drug Target Identification', FRONT CARDIOVASC MED, vol. 5, no. 47. https://doi.org/10.3389/fcvm.2018.00047

APA

Aarabi, G., Zeller, T., Heydecke, G., Munz, M., Schäfer, A., & Seedorf, U. (2018). Roles of the Chr.9p21.3 Locus in Regulating Inflammation and Implications for Anti-Inflammatory Drug Target Identification. FRONT CARDIOVASC MED, 5(47). https://doi.org/10.3389/fcvm.2018.00047

Vancouver

Aarabi G, Zeller T, Heydecke G, Munz M, Schäfer A, Seedorf U. Roles of the Chr.9p21.3 Locus in Regulating Inflammation and Implications for Anti-Inflammatory Drug Target Identification. FRONT CARDIOVASC MED. 2018 May 1;5(47). https://doi.org/10.3389/fcvm.2018.00047

Bibtex

@article{07023317af5c4bae9890c129c533795a,
title = "Roles of the Chr.9p21.3 Locus in Regulating Inflammation and Implications for Anti-Inflammatory Drug Target Identification",
abstract = "Periodontitis (PD) is a common gingival infectious disease caused by an over-aggressive inflammatory reaction to dysbiosis of the oral microbiome. The disease induces a profound systemic inflammatory host response, that triggers endothelial dysfunction and pro-thrombosis and thus may aggravate atherosclerotic vascular disease and its clinical complications. Recently, a risk haplotype at the ANRIL/CDKN2B-AS1 locus on chromosome 9p21.3, that is not only associated with coronary artery disease / myocardial infarction (CAD/MI) but also with PD, could be identified by genome-wide association studies. The locus encodes ANRIL - a long non-coding RNA (lncRNA) which, like other lncRNAs, regulates genome methylation via interacting with specific DNA sequences and proteins, such as DNA methyltranferases and polycomb proteins, thereby affecting expression of multiple genes by cis and trans mechanisms. Here, we describe ANRIL regulated genes and metabolic pathways and discuss implications of the findings for target identification of drugs with potentially anti-inflammatory activity in general.",
keywords = "Journal Article",
author = "Ghazal Aarabi and Tanja Zeller and Guido Heydecke and Matthias Munz and Arne Sch{\"a}fer and Udo Seedorf",
year = "2018",
month = may,
day = "1",
doi = "10.3389/fcvm.2018.00047",
language = "English",
volume = "5",
journal = "FRONT CARDIOVASC MED",
issn = "2297-055X",
publisher = "Frontiers Media S. A.",
number = "47",

}

RIS

TY - JOUR

T1 - Roles of the Chr.9p21.3 Locus in Regulating Inflammation and Implications for Anti-Inflammatory Drug Target Identification

AU - Aarabi, Ghazal

AU - Zeller, Tanja

AU - Heydecke, Guido

AU - Munz, Matthias

AU - Schäfer, Arne

AU - Seedorf, Udo

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Periodontitis (PD) is a common gingival infectious disease caused by an over-aggressive inflammatory reaction to dysbiosis of the oral microbiome. The disease induces a profound systemic inflammatory host response, that triggers endothelial dysfunction and pro-thrombosis and thus may aggravate atherosclerotic vascular disease and its clinical complications. Recently, a risk haplotype at the ANRIL/CDKN2B-AS1 locus on chromosome 9p21.3, that is not only associated with coronary artery disease / myocardial infarction (CAD/MI) but also with PD, could be identified by genome-wide association studies. The locus encodes ANRIL - a long non-coding RNA (lncRNA) which, like other lncRNAs, regulates genome methylation via interacting with specific DNA sequences and proteins, such as DNA methyltranferases and polycomb proteins, thereby affecting expression of multiple genes by cis and trans mechanisms. Here, we describe ANRIL regulated genes and metabolic pathways and discuss implications of the findings for target identification of drugs with potentially anti-inflammatory activity in general.

AB - Periodontitis (PD) is a common gingival infectious disease caused by an over-aggressive inflammatory reaction to dysbiosis of the oral microbiome. The disease induces a profound systemic inflammatory host response, that triggers endothelial dysfunction and pro-thrombosis and thus may aggravate atherosclerotic vascular disease and its clinical complications. Recently, a risk haplotype at the ANRIL/CDKN2B-AS1 locus on chromosome 9p21.3, that is not only associated with coronary artery disease / myocardial infarction (CAD/MI) but also with PD, could be identified by genome-wide association studies. The locus encodes ANRIL - a long non-coding RNA (lncRNA) which, like other lncRNAs, regulates genome methylation via interacting with specific DNA sequences and proteins, such as DNA methyltranferases and polycomb proteins, thereby affecting expression of multiple genes by cis and trans mechanisms. Here, we describe ANRIL regulated genes and metabolic pathways and discuss implications of the findings for target identification of drugs with potentially anti-inflammatory activity in general.

KW - Journal Article

U2 - 10.3389/fcvm.2018.00047

DO - 10.3389/fcvm.2018.00047

M3 - SCORING: Journal article

C2 - 29868613

VL - 5

JO - FRONT CARDIOVASC MED

JF - FRONT CARDIOVASC MED

SN - 2297-055X

IS - 47

ER -