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Role of tumor cell adhesion and migration in organ-specific metastasis formation

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Role of tumor cell adhesion and migration in organ-specific metastasis formation. / Gassmann, P; Enns, A; Haier, J.

In: ONKOLOGIE, Vol. 27, No. 6, 12.2004, p. 577-82.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gassmann, P, Enns, A & Haier, J 2004, 'Role of tumor cell adhesion and migration in organ-specific metastasis formation', ONKOLOGIE, vol. 27, no. 6, pp. 577-82. https://doi.org/10.1159/000081343

APA

Gassmann, P., Enns, A., & Haier, J. (2004). Role of tumor cell adhesion and migration in organ-specific metastasis formation. ONKOLOGIE, 27(6), 577-82. https://doi.org/10.1159/000081343

Vancouver

Gassmann P, Enns A, Haier J. Role of tumor cell adhesion and migration in organ-specific metastasis formation. ONKOLOGIE. 2004 Dec;27(6):577-82. https://doi.org/10.1159/000081343

Bibtex

@article{7858b73b73594ecca1115ec6eae6a8f5,
title = "Role of tumor cell adhesion and migration in organ-specific metastasis formation",
abstract = "To form clinically evident metastases--the main cause of death in cancer patients--, tumor cells (TC) must complete a highly complex series of steps called the metastatic cascade, including local invasiveness, intravasation, circulation, adhesion and extravasation, survival, proliferation and angiogenesis. Since failure of any one of these steps results in metastatic failure, understanding the metastatic cascade may guide us to new therapeutic concepts. Here we review the role of specific TC adhesion and migration processes for organ-selective metastasis formation. TC adhesion in the microvasculature of host organs is a specific and highly regulated process mainly mediated by selectins for TC/endothelial cell binding and by integrins for TC/extracellular matrix interactions. Defined expression of the adhesion molecules and their corresponding ligands in the host organs and on the TC governs organ-selective non-random TC arrest. TC motility and subsequent chemotactically guided extravasation of adherent cells is the second rate-limiting step in organ-specific metastasis formation. Only if cells have completed adhesion and extravasation the growth of micrometastases and finally clinically evident metastases can occur.",
keywords = "Animals, Cell Adhesion, Cell Communication, Cell Movement, Chemotaxis, Cytokines, Endothelium, Vascular, Humans, Neoplasm Metastasis, Neoplasms, Organ Specificity",
author = "P Gassmann and A Enns and J Haier",
year = "2004",
month = dec,
doi = "10.1159/000081343",
language = "English",
volume = "27",
pages = "577--82",
journal = "ONKOLOGIE",
issn = "0378-584X",
publisher = "S. Karger AG",
number = "6",

}

RIS

TY - JOUR

T1 - Role of tumor cell adhesion and migration in organ-specific metastasis formation

AU - Gassmann, P

AU - Enns, A

AU - Haier, J

PY - 2004/12

Y1 - 2004/12

N2 - To form clinically evident metastases--the main cause of death in cancer patients--, tumor cells (TC) must complete a highly complex series of steps called the metastatic cascade, including local invasiveness, intravasation, circulation, adhesion and extravasation, survival, proliferation and angiogenesis. Since failure of any one of these steps results in metastatic failure, understanding the metastatic cascade may guide us to new therapeutic concepts. Here we review the role of specific TC adhesion and migration processes for organ-selective metastasis formation. TC adhesion in the microvasculature of host organs is a specific and highly regulated process mainly mediated by selectins for TC/endothelial cell binding and by integrins for TC/extracellular matrix interactions. Defined expression of the adhesion molecules and their corresponding ligands in the host organs and on the TC governs organ-selective non-random TC arrest. TC motility and subsequent chemotactically guided extravasation of adherent cells is the second rate-limiting step in organ-specific metastasis formation. Only if cells have completed adhesion and extravasation the growth of micrometastases and finally clinically evident metastases can occur.

AB - To form clinically evident metastases--the main cause of death in cancer patients--, tumor cells (TC) must complete a highly complex series of steps called the metastatic cascade, including local invasiveness, intravasation, circulation, adhesion and extravasation, survival, proliferation and angiogenesis. Since failure of any one of these steps results in metastatic failure, understanding the metastatic cascade may guide us to new therapeutic concepts. Here we review the role of specific TC adhesion and migration processes for organ-selective metastasis formation. TC adhesion in the microvasculature of host organs is a specific and highly regulated process mainly mediated by selectins for TC/endothelial cell binding and by integrins for TC/extracellular matrix interactions. Defined expression of the adhesion molecules and their corresponding ligands in the host organs and on the TC governs organ-selective non-random TC arrest. TC motility and subsequent chemotactically guided extravasation of adherent cells is the second rate-limiting step in organ-specific metastasis formation. Only if cells have completed adhesion and extravasation the growth of micrometastases and finally clinically evident metastases can occur.

KW - Animals

KW - Cell Adhesion

KW - Cell Communication

KW - Cell Movement

KW - Chemotaxis

KW - Cytokines

KW - Endothelium, Vascular

KW - Humans

KW - Neoplasm Metastasis

KW - Neoplasms

KW - Organ Specificity

U2 - 10.1159/000081343

DO - 10.1159/000081343

M3 - SCORING: Journal article

C2 - 15591720

VL - 27

SP - 577

EP - 582

JO - ONKOLOGIE

JF - ONKOLOGIE

SN - 0378-584X

IS - 6

ER -