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Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study

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Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study. / Limperger, Verena; Kenet, Gili; Kiesau, Bettina; Köther, Max; Schmeiser, Malin; Langer, Florian; Juhl, David; Shneyder, Maria; Franke, Andre; Klostermeier, Ulrich K; Mesters, Rolf; Rühle, Frank; Stoll, Monika; Steppat, Dagmar; Kowalski, Dorothee; Rocke, Angela; Kuta, Piotr; Bajorat, Tido; Torge, Antje; Neuner, Bruno; Junker, Ralf; Nowak-Göttl, Ulrike.

In: J THROMB THROMBOLYS, Vol. 51, No. 2, 02.2021, p. 494-501.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Limperger, V, Kenet, G, Kiesau, B, Köther, M, Schmeiser, M, Langer, F, Juhl, D, Shneyder, M, Franke, A, Klostermeier, UK, Mesters, R, Rühle, F, Stoll, M, Steppat, D, Kowalski, D, Rocke, A, Kuta, P, Bajorat, T, Torge, A, Neuner, B, Junker, R & Nowak-Göttl, U 2021, 'Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study', J THROMB THROMBOLYS, vol. 51, no. 2, pp. 494-501. https://doi.org/10.1007/s11239-020-02169-6

APA

Limperger, V., Kenet, G., Kiesau, B., Köther, M., Schmeiser, M., Langer, F., Juhl, D., Shneyder, M., Franke, A., Klostermeier, U. K., Mesters, R., Rühle, F., Stoll, M., Steppat, D., Kowalski, D., Rocke, A., Kuta, P., Bajorat, T., Torge, A., ... Nowak-Göttl, U. (2021). Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study. J THROMB THROMBOLYS, 51(2), 494-501. https://doi.org/10.1007/s11239-020-02169-6

Vancouver

Limperger V, Kenet G, Kiesau B, Köther M, Schmeiser M, Langer F et al. Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study. J THROMB THROMBOLYS. 2021 Feb;51(2):494-501. https://doi.org/10.1007/s11239-020-02169-6

Bibtex

@article{f3957ab56e604da3ad6ceb2b3a9253b1,
title = "Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study",
abstract = "The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. To evaluate the presence of the F2 polymorphism in VTE patients compared to healthy blood donors and to adjust the results for common inherited thrombophilias [IT], age at onset and blood group [BG], and to calculate the risk of VTE recurrence. We investigated 1012 Caucasian patients with a diagnosis of VTE for the presence of the F2 rs3136516 polymorphism and compared these with 902 healthy blood donors. Odds ratios [OR] together with their 95% confidence intervals were calculated adjusted for F5 at rs6025, F2 at rs1799963, blood group, age and gender. In addition, we evaluated the risk of recurrent VTE during patient follow-up calculating hazard ratios [HR] together with their 95% CI. Compared with the AA wildtype, the F2 GG and AG genotypes (rs3136516) were associated with VTE (OR 1.48 and 1.45). The OR in F5 carriers compared to controls was 5.68 and 2.38 in patients with F2 (rs1799963). BG {"}non-O{"} was significantly more often diagnosed in patients compared to BG {"}O{"} (OR 2.74). VTE recurrence more often occurred in males (HR 2.3) and in carriers with combined thrombophilia (HR 2.11). Noteworthy, the rs3136516 polymorphism alone was not associated significantly with recurrence. In Caucasian patients with VTE the F2 GG/GA genotypes (rs3136516) were moderate risk factors for VTE. Recurrence was associated with male gender and combined thrombophilia.",
author = "Verena Limperger and Gili Kenet and Bettina Kiesau and Max K{\"o}ther and Malin Schmeiser and Florian Langer and David Juhl and Maria Shneyder and Andre Franke and Klostermeier, {Ulrich K} and Rolf Mesters and Frank R{\"u}hle and Monika Stoll and Dagmar Steppat and Dorothee Kowalski and Angela Rocke and Piotr Kuta and Tido Bajorat and Antje Torge and Bruno Neuner and Ralf Junker and Ulrike Nowak-G{\"o}ttl",
year = "2021",
month = feb,
doi = "10.1007/s11239-020-02169-6",
language = "English",
volume = "51",
pages = "494--501",
journal = "J THROMB THROMBOLYS",
issn = "0929-5305",
publisher = "Springer Netherlands",
number = "2",

}

RIS

TY - JOUR

T1 - Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study

AU - Limperger, Verena

AU - Kenet, Gili

AU - Kiesau, Bettina

AU - Köther, Max

AU - Schmeiser, Malin

AU - Langer, Florian

AU - Juhl, David

AU - Shneyder, Maria

AU - Franke, Andre

AU - Klostermeier, Ulrich K

AU - Mesters, Rolf

AU - Rühle, Frank

AU - Stoll, Monika

AU - Steppat, Dagmar

AU - Kowalski, Dorothee

AU - Rocke, Angela

AU - Kuta, Piotr

AU - Bajorat, Tido

AU - Torge, Antje

AU - Neuner, Bruno

AU - Junker, Ralf

AU - Nowak-Göttl, Ulrike

PY - 2021/2

Y1 - 2021/2

N2 - The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. To evaluate the presence of the F2 polymorphism in VTE patients compared to healthy blood donors and to adjust the results for common inherited thrombophilias [IT], age at onset and blood group [BG], and to calculate the risk of VTE recurrence. We investigated 1012 Caucasian patients with a diagnosis of VTE for the presence of the F2 rs3136516 polymorphism and compared these with 902 healthy blood donors. Odds ratios [OR] together with their 95% confidence intervals were calculated adjusted for F5 at rs6025, F2 at rs1799963, blood group, age and gender. In addition, we evaluated the risk of recurrent VTE during patient follow-up calculating hazard ratios [HR] together with their 95% CI. Compared with the AA wildtype, the F2 GG and AG genotypes (rs3136516) were associated with VTE (OR 1.48 and 1.45). The OR in F5 carriers compared to controls was 5.68 and 2.38 in patients with F2 (rs1799963). BG "non-O" was significantly more often diagnosed in patients compared to BG "O" (OR 2.74). VTE recurrence more often occurred in males (HR 2.3) and in carriers with combined thrombophilia (HR 2.11). Noteworthy, the rs3136516 polymorphism alone was not associated significantly with recurrence. In Caucasian patients with VTE the F2 GG/GA genotypes (rs3136516) were moderate risk factors for VTE. Recurrence was associated with male gender and combined thrombophilia.

AB - The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. To evaluate the presence of the F2 polymorphism in VTE patients compared to healthy blood donors and to adjust the results for common inherited thrombophilias [IT], age at onset and blood group [BG], and to calculate the risk of VTE recurrence. We investigated 1012 Caucasian patients with a diagnosis of VTE for the presence of the F2 rs3136516 polymorphism and compared these with 902 healthy blood donors. Odds ratios [OR] together with their 95% confidence intervals were calculated adjusted for F5 at rs6025, F2 at rs1799963, blood group, age and gender. In addition, we evaluated the risk of recurrent VTE during patient follow-up calculating hazard ratios [HR] together with their 95% CI. Compared with the AA wildtype, the F2 GG and AG genotypes (rs3136516) were associated with VTE (OR 1.48 and 1.45). The OR in F5 carriers compared to controls was 5.68 and 2.38 in patients with F2 (rs1799963). BG "non-O" was significantly more often diagnosed in patients compared to BG "O" (OR 2.74). VTE recurrence more often occurred in males (HR 2.3) and in carriers with combined thrombophilia (HR 2.11). Noteworthy, the rs3136516 polymorphism alone was not associated significantly with recurrence. In Caucasian patients with VTE the F2 GG/GA genotypes (rs3136516) were moderate risk factors for VTE. Recurrence was associated with male gender and combined thrombophilia.

U2 - 10.1007/s11239-020-02169-6

DO - 10.1007/s11239-020-02169-6

M3 - SCORING: Journal article

C2 - 32594420

VL - 51

SP - 494

EP - 501

JO - J THROMB THROMBOLYS

JF - J THROMB THROMBOLYS

SN - 0929-5305

IS - 2

ER -