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Role of mechanical factors in the morphology of the primate cerebral cortex

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Role of mechanical factors in the morphology of the primate cerebral cortex. / Hilgetag, Claus C; Barbas, Helen.

In: PLOS COMPUT BIOL, Vol. 2, No. 3, 03.2006, p. e22.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hilgetag, CC & Barbas, H 2006, 'Role of mechanical factors in the morphology of the primate cerebral cortex', PLOS COMPUT BIOL, vol. 2, no. 3, pp. e22. https://doi.org/10.1371/journal.pcbi.0020022

APA

Hilgetag, C. C., & Barbas, H. (2006). Role of mechanical factors in the morphology of the primate cerebral cortex. PLOS COMPUT BIOL, 2(3), e22. https://doi.org/10.1371/journal.pcbi.0020022

Vancouver

Hilgetag CC, Barbas H. Role of mechanical factors in the morphology of the primate cerebral cortex. PLOS COMPUT BIOL. 2006 Mar;2(3):e22. https://doi.org/10.1371/journal.pcbi.0020022

Bibtex

@article{1983b54917c24bdeb9b2a956f61c2493,
title = "Role of mechanical factors in the morphology of the primate cerebral cortex",
abstract = "The convoluted cortex of primates is instantly recognizable in its principal morphologic features, yet puzzling in its complex finer structure. Various hypotheses have been proposed about the mechanisms of its formation. Based on the analysis of databases of quantitative architectonic and connection data for primate prefrontal cortices, we offer support for the hypothesis that tension exerted by corticocortical connections is a significant factor in shaping the cerebral cortical landscape. Moreover, forces generated by cortical folding influence laminar morphology, and appear to have a previously unsuspected impact on cellular migration during cortical development. The evidence for a significant role of mechanical factors in cortical morphology opens the possibility of constructing computational models of cortical development based on physical principles. Such models are particularly relevant for understanding the relationship of cortical morphology to the connectivity of normal brains, and structurally altered brains in diseases of developmental origin, such as schizophrenia and autism.",
keywords = "Algorithms, Animals, Autistic Disorder, Axons, Brain Mapping, Cerebral Cortex, Computational Biology, Humans, Macaca mulatta, Models, Statistical, Neural Pathways, Neurons, Prefrontal Cortex, Schizophrenia, Journal Article, Research Support, N.I.H., Extramural",
author = "Hilgetag, {Claus C} and Helen Barbas",
year = "2006",
month = mar,
doi = "10.1371/journal.pcbi.0020022",
language = "English",
volume = "2",
pages = "e22",
journal = "PLOS COMPUT BIOL",
issn = "1553-734X",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Role of mechanical factors in the morphology of the primate cerebral cortex

AU - Hilgetag, Claus C

AU - Barbas, Helen

PY - 2006/3

Y1 - 2006/3

N2 - The convoluted cortex of primates is instantly recognizable in its principal morphologic features, yet puzzling in its complex finer structure. Various hypotheses have been proposed about the mechanisms of its formation. Based on the analysis of databases of quantitative architectonic and connection data for primate prefrontal cortices, we offer support for the hypothesis that tension exerted by corticocortical connections is a significant factor in shaping the cerebral cortical landscape. Moreover, forces generated by cortical folding influence laminar morphology, and appear to have a previously unsuspected impact on cellular migration during cortical development. The evidence for a significant role of mechanical factors in cortical morphology opens the possibility of constructing computational models of cortical development based on physical principles. Such models are particularly relevant for understanding the relationship of cortical morphology to the connectivity of normal brains, and structurally altered brains in diseases of developmental origin, such as schizophrenia and autism.

AB - The convoluted cortex of primates is instantly recognizable in its principal morphologic features, yet puzzling in its complex finer structure. Various hypotheses have been proposed about the mechanisms of its formation. Based on the analysis of databases of quantitative architectonic and connection data for primate prefrontal cortices, we offer support for the hypothesis that tension exerted by corticocortical connections is a significant factor in shaping the cerebral cortical landscape. Moreover, forces generated by cortical folding influence laminar morphology, and appear to have a previously unsuspected impact on cellular migration during cortical development. The evidence for a significant role of mechanical factors in cortical morphology opens the possibility of constructing computational models of cortical development based on physical principles. Such models are particularly relevant for understanding the relationship of cortical morphology to the connectivity of normal brains, and structurally altered brains in diseases of developmental origin, such as schizophrenia and autism.

KW - Algorithms

KW - Animals

KW - Autistic Disorder

KW - Axons

KW - Brain Mapping

KW - Cerebral Cortex

KW - Computational Biology

KW - Humans

KW - Macaca mulatta

KW - Models, Statistical

KW - Neural Pathways

KW - Neurons

KW - Prefrontal Cortex

KW - Schizophrenia

KW - Journal Article

KW - Research Support, N.I.H., Extramural

U2 - 10.1371/journal.pcbi.0020022

DO - 10.1371/journal.pcbi.0020022

M3 - SCORING: Journal article

C2 - 16557292

VL - 2

SP - e22

JO - PLOS COMPUT BIOL

JF - PLOS COMPUT BIOL

SN - 1553-734X

IS - 3

ER -