Research ExplorerPublicationsRole of L1CAM for axon sprouting and branching.

Role of L1CAM for axon sprouting and branching.

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Role of L1CAM for axon sprouting and branching. / Schäfer, Michael K E; Frotscher, Michael.

In: CELL TISSUE RES, Vol. 349, No. 1, 1, 2012, p. 39-48.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schäfer, MKE & Frotscher, M 2012, 'Role of L1CAM for axon sprouting and branching.', CELL TISSUE RES, vol. 349, no. 1, 1, pp. 39-48. <http://www.ncbi.nlm.nih.gov/pubmed/22370595?dopt=Citation>

APA

Schäfer, M. K. E., & Frotscher, M. (2012). Role of L1CAM for axon sprouting and branching. CELL TISSUE RES, 349(1), 39-48. [1]. http://www.ncbi.nlm.nih.gov/pubmed/22370595?dopt=Citation

Vancouver

Schäfer MKE, Frotscher M. Role of L1CAM for axon sprouting and branching. CELL TISSUE RES. 2012;349(1):39-48. 1.

Bibtex

@article{5b32d4ce278048c390c0c3bfcae96524,
title = "Role of L1CAM for axon sprouting and branching.",
abstract = "The central nervous system (CNS) has been traditionally considered as an organ that fails to regenerate in response to injury. Indeed, the lesioned CNS faces a number of obstacles during regeneration, including an overall non-permissive environment for axonal regeneration. However, research during the last few decades has identified axon sprouting as an anatomical correlate for the regenerative capability of the CNS to establish new connections. The immunoglobulin superfamily member L1CAM has been shown to promote the capability of neurons for regenerative axon sprouting and to improve behavioral outcomes after CNS injury. Here, we discuss the cell-autonomous role of L1CAM for axon sprouting in experimental rodent injury models and highlight the molecular interactions of L1CAM with ankyrins, ezrin-radixin-moesin proteins and the Sema3A/Neuropilin ligand-receptor complex in the context of axonal branching.",
keywords = "Animals, Humans, Models, Biological, Neural Cell Adhesion Molecule L1/chemistry/*metabolism, Ankyrins/metabolism, Axons/*metabolism/pathology, Cytoskeletal Proteins/metabolism, Animals, Humans, Models, Biological, Neural Cell Adhesion Molecule L1/chemistry/*metabolism, Ankyrins/metabolism, Axons/*metabolism/pathology, Cytoskeletal Proteins/metabolism",
author = "Sch{\"a}fer, {Michael K E} and Michael Frotscher",
year = "2012",
language = "English",
volume = "349",
pages = "39--48",
journal = "CELL TISSUE RES",
issn = "0302-766X",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Role of L1CAM for axon sprouting and branching.

AU - Schäfer, Michael K E

AU - Frotscher, Michael

PY - 2012

Y1 - 2012

N2 - The central nervous system (CNS) has been traditionally considered as an organ that fails to regenerate in response to injury. Indeed, the lesioned CNS faces a number of obstacles during regeneration, including an overall non-permissive environment for axonal regeneration. However, research during the last few decades has identified axon sprouting as an anatomical correlate for the regenerative capability of the CNS to establish new connections. The immunoglobulin superfamily member L1CAM has been shown to promote the capability of neurons for regenerative axon sprouting and to improve behavioral outcomes after CNS injury. Here, we discuss the cell-autonomous role of L1CAM for axon sprouting in experimental rodent injury models and highlight the molecular interactions of L1CAM with ankyrins, ezrin-radixin-moesin proteins and the Sema3A/Neuropilin ligand-receptor complex in the context of axonal branching.

AB - The central nervous system (CNS) has been traditionally considered as an organ that fails to regenerate in response to injury. Indeed, the lesioned CNS faces a number of obstacles during regeneration, including an overall non-permissive environment for axonal regeneration. However, research during the last few decades has identified axon sprouting as an anatomical correlate for the regenerative capability of the CNS to establish new connections. The immunoglobulin superfamily member L1CAM has been shown to promote the capability of neurons for regenerative axon sprouting and to improve behavioral outcomes after CNS injury. Here, we discuss the cell-autonomous role of L1CAM for axon sprouting in experimental rodent injury models and highlight the molecular interactions of L1CAM with ankyrins, ezrin-radixin-moesin proteins and the Sema3A/Neuropilin ligand-receptor complex in the context of axonal branching.

KW - Animals

KW - Humans

KW - Models, Biological

KW - Neural Cell Adhesion Molecule L1/chemistry/metabolism

KW - Ankyrins/metabolism

KW - Axons/metabolism/pathology

KW - Cytoskeletal Proteins/metabolism

KW - Animals

KW - Humans

KW - Models, Biological

KW - Neural Cell Adhesion Molecule L1/chemistry/metabolism

KW - Ankyrins/metabolism

KW - Axons/metabolism/pathology

KW - Cytoskeletal Proteins/metabolism

M3 - SCORING: Journal article

VL - 349

SP - 39

EP - 48

JO - CELL TISSUE RES

JF - CELL TISSUE RES

SN - 0302-766X

IS - 1

M1 - 1

ER -