Role of dendritic cells in the regulation of maternal immune responses to the fetus during mammalian gestation.
Standard
Role of dendritic cells in the regulation of maternal immune responses to the fetus during mammalian gestation. / Kammerer, Ulrike; Kruse, Andrea; Barrientos, Gabriela; Arck, Petra; Blois, Sandra M.
In: IMMUNOL INVEST, Vol. 37, No. 5, 5, 2008, p. 499-533.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Role of dendritic cells in the regulation of maternal immune responses to the fetus during mammalian gestation.
AU - Kammerer, Ulrike
AU - Kruse, Andrea
AU - Barrientos, Gabriela
AU - Arck, Petra
AU - Blois, Sandra M
PY - 2008
Y1 - 2008
N2 - Successful mammalian pregnancy relies on the action of sophisticated regulatory mechanisms that allow the fetus (a semi-allograft) to grow and develop in the uterus in spite of being recognized by maternal immune cells. Among several immunocompetent cells present at the maternal fetal interface, dendritic cells (DC) seem to be of particular relevance for pregnancy maintenance given their unique ability to induce both antigen-specific immunity and tolerance. Thus, these cells would be potentially suitable candidates for the regulation of local immune responses within the uterus necessary to meet the difficult task of protecting the mother from infection without compromising fetal survival. Current evidence on decidual DC phenotype and function, and their role in the regulation of the maternal immune system during mouse and human pregnancy are discussed and reviewed herein; highlighting novel DC functions that seem to be of great importance for a successful pregnancy outcome.
AB - Successful mammalian pregnancy relies on the action of sophisticated regulatory mechanisms that allow the fetus (a semi-allograft) to grow and develop in the uterus in spite of being recognized by maternal immune cells. Among several immunocompetent cells present at the maternal fetal interface, dendritic cells (DC) seem to be of particular relevance for pregnancy maintenance given their unique ability to induce both antigen-specific immunity and tolerance. Thus, these cells would be potentially suitable candidates for the regulation of local immune responses within the uterus necessary to meet the difficult task of protecting the mother from infection without compromising fetal survival. Current evidence on decidual DC phenotype and function, and their role in the regulation of the maternal immune system during mouse and human pregnancy are discussed and reviewed herein; highlighting novel DC functions that seem to be of great importance for a successful pregnancy outcome.
M3 - SCORING: Zeitschriftenaufsatz
VL - 37
SP - 499
EP - 533
JO - IMMUNOL INVEST
JF - IMMUNOL INVEST
SN - 0882-0139
IS - 5
M1 - 5
ER -
