Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?

TY - JOUR

T1 - Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?

AU - Benzi, Andrea

AU - Grozio, Alessia

AU - Spinelli, Sonia

AU - Sturla, Laura

AU - Guse, Andreas H

AU - De Flora, Antonio

AU - Zocchi, Elena

AU - Heeren, Joerg

AU - Bruzzone, Santina

PY - 2021/10/23

Y1 - 2021/10/23

N2 - Nicotinamide adenine dinucleotide (NAD+) is a fundamental molecule in the regulation of energy metabolism, representing both a coenzyme and a substrate for different NAD+ degrading enzymes. Among these enzymes, CD38 can be seen under two perspectives: as the enzyme synthesizing Ca2+-mobilizing second messenger, starting from NAD+, and as the major NAD+-consumer, to be inhibited to increase NAD+ levels. Indeed, the regulation of NAD+ availability is a key event during different processes. In this review, we examine the recent studies related to the modulation of CD38 expression and activity, and the consequent changes in NAD(P)(H), in adipose tissue, during inflammation and cold-induced thermogenesis.

AB - Nicotinamide adenine dinucleotide (NAD+) is a fundamental molecule in the regulation of energy metabolism, representing both a coenzyme and a substrate for different NAD+ degrading enzymes. Among these enzymes, CD38 can be seen under two perspectives: as the enzyme synthesizing Ca2+-mobilizing second messenger, starting from NAD+, and as the major NAD+-consumer, to be inhibited to increase NAD+ levels. Indeed, the regulation of NAD+ availability is a key event during different processes. In this review, we examine the recent studies related to the modulation of CD38 expression and activity, and the consequent changes in NAD(P)(H), in adipose tissue, during inflammation and cold-induced thermogenesis.

U2 - 10.3390/nu13113734

DO - 10.3390/nu13113734

M3 - SCORING: Review article

C2 - 34835990

VL - 13

JO - NUTRIENTS

JF - NUTRIENTS

SN - 2072-6643

IS - 11

M1 - 3734

ER -