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Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells.

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Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells. / Huber, Samuel; Schramm, Christoph.

In: CRIT REV IMMUNOL, Vol. 31, No. 1, 1, 2011, p. 53-60.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Huber, S & Schramm, C 2011, 'Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells.', CRIT REV IMMUNOL, vol. 31, no. 1, 1, pp. 53-60. <http://www.ncbi.nlm.nih.gov/pubmed/21395511?dopt=Citation>

APA

Huber, S., & Schramm, C. (2011). Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells. CRIT REV IMMUNOL, 31(1), 53-60. [1]. http://www.ncbi.nlm.nih.gov/pubmed/21395511?dopt=Citation

Vancouver

Huber S, Schramm C. Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells. CRIT REV IMMUNOL. 2011;31(1):53-60. 1.

Bibtex

@article{8b16d8fd8a95428892ca231b57f58646,
title = "Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells.",
abstract = "Regulatory T cells (Tregs) play a crucial role in the maintenance of immune homeostasis. The two best studied types of CD4(+) regulatory T cells are the Foxp3(+) Tregs and the T regulatory type 1 (Tr1) cells. CD4(+) regulatory T cells play a protective role in autoimmune disease. On the other hand, they also may have pathogenic properties in infectious diseases and carcinogenesis. Because of their potential for the therapy of various human diseases, factors responsible for expanding regulatory T cells are of interest. One of these factors, the TGFbeta family member activin A, is expressed in different inflammatory conditions, such as inflammatory bowel disease, rheumatoid arthritis, and asthma. Although activin A might have pro- and anti-inflammatory properties depending on the context of expression, this review focuses on the role of activin A for the expansion of the CD4(+) regulatory T-cell pool.",
keywords = "Animals, Humans, Signal Transduction, Cell Differentiation, Activins/*immunology/metabolism, Forkhead Transcription Factors/*immunology, T-Lymphocytes, Regulatory/cytology/*immunology/metabolism, Transforming Growth Factor beta/immunology, Animals, Humans, Signal Transduction, Cell Differentiation, Activins/*immunology/metabolism, Forkhead Transcription Factors/*immunology, T-Lymphocytes, Regulatory/cytology/*immunology/metabolism, Transforming Growth Factor beta/immunology",
author = "Samuel Huber and Christoph Schramm",
year = "2011",
language = "English",
volume = "31",
pages = "53--60",
number = "1",

}

RIS

TY - JOUR

T1 - Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells.

AU - Huber, Samuel

AU - Schramm, Christoph

PY - 2011

Y1 - 2011

N2 - Regulatory T cells (Tregs) play a crucial role in the maintenance of immune homeostasis. The two best studied types of CD4(+) regulatory T cells are the Foxp3(+) Tregs and the T regulatory type 1 (Tr1) cells. CD4(+) regulatory T cells play a protective role in autoimmune disease. On the other hand, they also may have pathogenic properties in infectious diseases and carcinogenesis. Because of their potential for the therapy of various human diseases, factors responsible for expanding regulatory T cells are of interest. One of these factors, the TGFbeta family member activin A, is expressed in different inflammatory conditions, such as inflammatory bowel disease, rheumatoid arthritis, and asthma. Although activin A might have pro- and anti-inflammatory properties depending on the context of expression, this review focuses on the role of activin A for the expansion of the CD4(+) regulatory T-cell pool.

AB - Regulatory T cells (Tregs) play a crucial role in the maintenance of immune homeostasis. The two best studied types of CD4(+) regulatory T cells are the Foxp3(+) Tregs and the T regulatory type 1 (Tr1) cells. CD4(+) regulatory T cells play a protective role in autoimmune disease. On the other hand, they also may have pathogenic properties in infectious diseases and carcinogenesis. Because of their potential for the therapy of various human diseases, factors responsible for expanding regulatory T cells are of interest. One of these factors, the TGFbeta family member activin A, is expressed in different inflammatory conditions, such as inflammatory bowel disease, rheumatoid arthritis, and asthma. Although activin A might have pro- and anti-inflammatory properties depending on the context of expression, this review focuses on the role of activin A for the expansion of the CD4(+) regulatory T-cell pool.

KW - Animals

KW - Humans

KW - Signal Transduction

KW - Cell Differentiation

KW - Activins/immunology/metabolism

KW - Forkhead Transcription Factors/immunology

KW - T-Lymphocytes, Regulatory/cytology/immunology/metabolism

KW - Transforming Growth Factor beta/immunology

KW - Animals

KW - Humans

KW - Signal Transduction

KW - Cell Differentiation

KW - Activins/immunology/metabolism

KW - Forkhead Transcription Factors/immunology

KW - T-Lymphocytes, Regulatory/cytology/immunology/metabolism

KW - Transforming Growth Factor beta/immunology

M3 - SCORING: Journal article

VL - 31

SP - 53

EP - 60

IS - 1

M1 - 1

ER -