Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering

Yiqi Pan; Zhiwei Jiang; Yuer Ye; Danji Zhu; Na Li; Guoli Yang; Ying Wang

doi:10.1007/s10439-023-03173-6

Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering

Standard

Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering. / Pan, Yiqi; Jiang, Zhiwei; Ye, Yuer; Zhu, Danji; Li, Na; Yang, Guoli; Wang, Ying.

In: ANN BIOMED ENG, Vol. 51, No. 7, 07.2023, p. 1374-1389.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Pan, Y, Jiang, Z, Ye, Y, Zhu, D, Li, N, Yang, G & Wang, Y 2023, 'Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering', ANN BIOMED ENG, vol. 51, no. 7, pp. 1374-1389. https://doi.org/10.1007/s10439-023-03173-6

APA

Pan, Y., Jiang, Z., Ye, Y., Zhu, D., Li, N., Yang, G., & Wang, Y. (2023). Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering. ANN BIOMED ENG, 51(7), 1374-1389. https://doi.org/10.1007/s10439-023-03173-6

Vancouver

Pan Y, Jiang Z, Ye Y, Zhu D, Li N, Yang G et al. Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering. ANN BIOMED ENG. 2023 Jul;51(7):1374-1389. https://doi.org/10.1007/s10439-023-03173-6

Bibtex

@article{e6e9c82047914065a3295dde9c444f64,

title = "Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering",

abstract = "Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for regenerative medicine and tissue engineering. BMP4 has been shown to promote the regeneration of teeth, periodontal tissue, bone, cartilage, the thymus, hair, neurons, nucleus pulposus, and adipose tissue, as well as the formation of skeletal myotubes and vessels. BMP4 can also contribute to the formation of tissues in the heart, lung, and kidney. However, there are certain deficiencies, including the insufficiency of the mechanism of BMP4 in some fields and an appropriate carrier of BMP4 for clinical use. There has also been a lack of in vivo experiments and orthotopic transplantation studies in some fields. BMP4 has great distance from the clinical application. Therefore, there are many BMP4-related studies waiting to be explored. This review mainly discusses the effects, mechanisms, and applications of BMP4 in regenerative medicine and tissue engineering over the last 10 years in various domains and possible improvements. BMP4 has shown great potential in regenerative medicine and tissue engineering. The research of BMP4 has broad development space and great value.",

keywords = "Bone and Bones/metabolism, Bone Morphogenetic Protein 4, Cartilage/metabolism, Regenerative Medicine, Tissue Engineering, Humans, Animals",

author = "Yiqi Pan and Zhiwei Jiang and Yuer Ye and Danji Zhu and Na Li and Guoli Yang and Ying Wang",

note = "{\textcopyright} 2023. The Author(s) under exclusive licence to Biomedical Engineering Society.",

year = "2023",

month = jul,

doi = "10.1007/s10439-023-03173-6",

language = "English",

volume = "51",

pages = "1374--1389",

number = "7",

}

RIS

TY - JOUR

T1 - Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering

AU - Pan, Yiqi

AU - Jiang, Zhiwei

AU - Ye, Yuer

AU - Zhu, Danji

AU - Li, Na

AU - Yang, Guoli

AU - Wang, Ying

PY - 2023/7

Y1 - 2023/7

N2 - Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for regenerative medicine and tissue engineering. BMP4 has been shown to promote the regeneration of teeth, periodontal tissue, bone, cartilage, the thymus, hair, neurons, nucleus pulposus, and adipose tissue, as well as the formation of skeletal myotubes and vessels. BMP4 can also contribute to the formation of tissues in the heart, lung, and kidney. However, there are certain deficiencies, including the insufficiency of the mechanism of BMP4 in some fields and an appropriate carrier of BMP4 for clinical use. There has also been a lack of in vivo experiments and orthotopic transplantation studies in some fields. BMP4 has great distance from the clinical application. Therefore, there are many BMP4-related studies waiting to be explored. This review mainly discusses the effects, mechanisms, and applications of BMP4 in regenerative medicine and tissue engineering over the last 10 years in various domains and possible improvements. BMP4 has shown great potential in regenerative medicine and tissue engineering. The research of BMP4 has broad development space and great value.

AB - Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for regenerative medicine and tissue engineering. BMP4 has been shown to promote the regeneration of teeth, periodontal tissue, bone, cartilage, the thymus, hair, neurons, nucleus pulposus, and adipose tissue, as well as the formation of skeletal myotubes and vessels. BMP4 can also contribute to the formation of tissues in the heart, lung, and kidney. However, there are certain deficiencies, including the insufficiency of the mechanism of BMP4 in some fields and an appropriate carrier of BMP4 for clinical use. There has also been a lack of in vivo experiments and orthotopic transplantation studies in some fields. BMP4 has great distance from the clinical application. Therefore, there are many BMP4-related studies waiting to be explored. This review mainly discusses the effects, mechanisms, and applications of BMP4 in regenerative medicine and tissue engineering over the last 10 years in various domains and possible improvements. BMP4 has shown great potential in regenerative medicine and tissue engineering. The research of BMP4 has broad development space and great value.

KW - Bone and Bones/metabolism

KW - Bone Morphogenetic Protein 4

KW - Cartilage/metabolism

KW - Regenerative Medicine

KW - Tissue Engineering

KW - Humans

KW - Animals

U2 - 10.1007/s10439-023-03173-6

DO - 10.1007/s10439-023-03173-6

M3 - SCORING: Review article

C2 - 37014581

VL - 51

SP - 1374

EP - 1389

IS - 7

ER -